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3D MRI-based tumor delineation of ocular melanoma and its comparison with conventional techniques
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Image of FIG. 1.
FIG. 1.

(a) Indirect ophthalmoscopy and point source transillumination to delineate the tumor margins. (b) Tantalum rings 2.5 mm in diameter and 0.2 mm thick are sutured to the sclera to allow tumor localization during proton beam irradiation.

Image of FIG. 2.
FIG. 2.

Calculation of tumor volume based on spherical model.

Image of FIG. 3.
FIG. 3.

Shows the schematics of the reconstruction of 3D T2 fast spin echo imaging. The zero filling reconstruction occurs before the inverse digital Fourier transform, which separates the volume signal into individual slices. The interpolation between the slices is caused by the zero filling such that the resulting image locations overlap each other. This figure was generated by reading individual MRI slices into image processing software tool of MATLAB (Ref. 28) and creating the 3D image.

Image of FIG. 4.
FIG. 4.

The tumor volume identified by two observers (physicians) in comparison to the tumor volume obtained from EYEPLAN software. (a) For small and medium size tumors and (b) large and extra-large tumors. The differences among tumor volumes in comparison to EYEPLAN tumor volume were minimum.

Image of FIG. 5.
FIG. 5.

Illustrates an example of uveal melanoma of the choroid. (a) The A-scan ultra sonogram showing a typical pattern of a uveal melanoma, which exhibits spontaneous pulsations, low to moderate reflectivity, and a relatively sharp posterior spike. (b) The B scan, demonstrates a tumor (arrow) showing marked growth of the lesion to 8.3 mm in anterior-to-posterior height. (c) Axial 3D T2-weighted FSE MRI slices showing the dome shaped tumor in the left eye. (d) Shows the fundus view of the same lesion. (e) Illustrates the treatment plan in the beam’s eye view of the lesion using polar and azumith angle of (25°,0°). Various structures in the model are labeled. The contour around the tumor represents the 50% isodose line. (f) The tumor surface generated by stacking the tumor contours on sequential MRI slices using MATLAB image processing system.

Image of FIG. 6.
FIG. 6.

Tumor volume measured for different patients using EYEPLAN, 3D MRI, and 2D MRI techniques.


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Characteristics of patients examined with 3D T2 FSE MRI imaging between March 2003 and March 2005.

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Intraobserver coefficient of variance calculated for each observer and for EYEPLAN. The results are not statistically significant between both methods of estimation.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: 3D MRI-based tumor delineation of ocular melanoma and its comparison with conventional techniques