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Internal radionuclide therapy: The ULMDOS software for treatment planning
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View: Figures


Image of FIG. 1.
FIG. 1.

Software design and overview of data workflow ( user interface).

Image of FIG. 2.
FIG. 2.

ROI GUI showing a patient with acute myeloid leukemia after injection of 141 MBq -labeled anti-CD66 antibody, acquired on a double-head gamma camera (ECAM, Siemens, Erlangen, Germany). Mirrored anterior (left) and posterior image together with the ROI of the selected organ (spleen). The pixel numbers and the geometric mean count rates of the drawn ROIs (SUM, MEAN, SD) and of the (potentially scaled) organ counts (, SUM) were displayed on the right-hand side. The syringe with residual activity is used as standard.

Image of FIG. 3.
FIG. 3.

PLOT&FIT GUI. Result for the same patient as in Fig. 2. (Top) table of calculated percent administered activity for the used organs. (Bottom, left) plot of TAC data for a selected organ (bone marrow) together with fitted curve, fit parameters, the residence time for the chosen radionuclide and divided by the degrees of freedom (DoF). An outlier ( p.i.) is eliminated. (Bottom, right) selection of fit function (ORGAN2), fit algorithm (Levenberg-Marquardt or Amoeba), and (editable) fit parameter start and result values. Parameter is held fixed. The window below the fit parameters displays the output of the fit routines.

Image of FIG. 4.
FIG. 4.

The results for the calculated residence times using ULMDOS and the standard procedure in the Department of Nuclear Medicine, University of Ulm, are shown. Note that the variability is due to differences in drawing regions of interest on two different computers.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Internal radionuclide therapy: The ULMDOS software for treatment planning