Experimental setup, with the mouse leg located in the focal region of the ultrasound.
Illustration of a typical ultrasound pulse sequence (US) and its corresponding “boxed” representation (BUS).
The ratio signal with the trend modulated ultrasound pulse signal superimposed for a typical (a) normal leg muscle tissue and (b) tumor tissue. Notice the much larger ultrasound induced contrast in the normal leg muscle signal.
Illustration of “boxed” ultrasound signal (BUS), observation “windows,” and comb signal with spikes at the positions of local minima (calculated for each “window”).
Laser Doppler relative average volume velocity shown with ultrasound bursts and vertical lines for reference for normal leg muscle (a) and tumor (b) tissue samples. The normal leg muscle samples have greater blood volume flow rates.
A sample of an in vivo spectra of a healthy tissue sample with a fit used to determine the oxy/deoxyhemoglobin saturations and the scattering properties of the tissue.
Parameters derived using the fitting algorithm applied to the collected broadband diffuse reflectance spectra: (a) oxyhemoglobin concentration; (b) deoxyhemoglobin concentration; (c) scattering coefficient; (d) scattering exponent; and (e) total hemoglobin concentration. The vertical lines reference the beginning of the five second bursts of ultrasound.
The signal which reflects the changes in oxyhemoglobin concentrations.
The signal in normal leg muscle tissue is better correlated to the ultrasound than the same signal for tumor tissue, measured for the same mouse to compensate for physiological differences in mice population.
ROC curve for the diagnostic algorithm. Decision threshold varied from 0.1 to 1 in 0.05 steps. Area under the curve is 0.90.
Vessel staining of (a) tumor and (c) normal leg muscle tissue samples. Corresponding perfused vessel stains for the same samples are shown in (b) and (d), respectively.
The ratio signal for nontumor tissue with the trend modulated ultrasound pulse superimposed. The ultrasound-induced drops are difficult to distinguish.
Experimental data used to calculate ROC.
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