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Impact of target-to-background ratio, target size, emission scan duration, and activity on physical figures of merit for a 3D LSO-based whole body PET/CT scanner
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10.1118/1.2776242
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    Affiliations:
    1 Department of Medical Physics, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    2 Department of Nuclear Medicine, Università degli Studi del Piemonte Orientale A. Avogadro, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    3 Department of Medical Physics, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    4 Department of Nuclear Medicine, Università degli Studi del Piemonte Orientale A. Avogadro, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    5 Department of Radiology, Università degli Studi del Piemonte Orientale A. Avogadro, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    6 Department of Nuclear Medicine, Università degli Studi del Piemonte Orientale A. Avogadro, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
    a) Author to whom correspondence should be addressed. Electronic mail: marco.brambilla@maggioreosp.novara.it
    Med. Phys. 34, 3854 (2007); http://dx.doi.org/10.1118/1.2776242
/content/aapm/journal/medphys/34/10/10.1118/1.2776242
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/10/10.1118/1.2776242

Figures

Image of FIG. 1.
FIG. 1.

(a) The and (b) R rates as a function of for the IEC and modified IEC plus scatter phantoms. Superimposed is a scatterplot reporting the and R rates in and in patients. NECR curve (c) for the IEC and modified IEC plus scatter phantoms.

Image of FIG. 2.
FIG. 2.

Reconstructed images from acquisitions with , background concentration of and ESD of (a) , (b) , (c) and (d) . Top panel contains hot lesions of 22, 17, 13, and (clockwise from bottom left). Bottom panel contains hot lesions of 8.1, 6.5, 4.7, and (clockwise from middle right).

Image of FIG. 3.
FIG. 3.

3D scatterplot of observed plotted against sphere IDs and T/B ratios.

Image of FIG. 4.
FIG. 4.

Box-plots for BV, with respect to (a) sphere ID, (b) ESD, and (c) .

Image of FIG. 5.
FIG. 5.

Box-plots for CNR, with respect to (a) ESD, (b) T/B ratio, (c) sphere ID, and (d) . The analysis of residual for , BV and CNR did not show any significant departure from normality assumptions (p=0.20, 0.06, and 0.15, respectively). Some of the more useful graphs for checking assumptions of linearity in multiple regressions will involve plotting residuals versus predictor values. A horizontal band of points should be obtained with no hint of systematic trends, and this is indeed our case (not shown).

Tables

Generic image for table
TABLE I.

Results of visual detection of hot spheres for different T/B ratios, activity concentrations, and ESD for different sphere ID: Gray/white boxes indicate a detectable/undetectable sphere.

Generic image for table
TABLE II.

values [mean standard deviation (number of cases)] for different sphere IDs and T/B ratios.

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2007-09-18
2014-04-23
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Impact of target-to-background ratio, target size, emission scan duration, and activity on physical figures of merit for a 3D LSO-based whole body PET/CT scanner
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/10/10.1118/1.2776242
10.1118/1.2776242
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