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BGRT: Biologically guided radiation therapy—The future is fast approaching!
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10.1118/1.2779861
/content/aapm/journal/medphys/34/10/10.1118/1.2779861
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/10/10.1118/1.2779861
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Prescription doses for the treatment of prostate cancer equivalent to 37 daily fractions of (filled circle). A fraction delivery time ( parameter) of is used to compute for all treatments [refer to Eq. (7)]. Solid lines denote prescription doses estimated using the Fowler et al. (Ref. 91) radiosensitivity parameters. Dashed lines indicate prescription doses estimated using the Wang et al. (Ref. 92) radiosensitivity parameters.

Image of FIG. 2.
FIG. 2.

Potential impact of interpatient heterogeneity on the determination of isoeffective prescription doses. All prescription doses are equivalent to a reference treatment composed of 37 fractions of (filled circles). A fraction delivery time ( parameter) of is used to compute for all treatments [refer to Eq. (7)]. The solid and dotted lines are the mean and 95% confidence interval, respectively, derived from estimated prescription doses for patients. Patient radiosensitivity parameters sampled from a uniform probability density function using Monte Carlo methods: ( to ), ( to ), ( to ), and ( to ).

Image of FIG. 3.
FIG. 3.

Simplified relationships between relative cerebral blood volume (rCBV) and (solid line) or (dashed line) for malignant glioma (Ref. 114).

Image of FIG. 4.
FIG. 4.

Flowchart illustrating a proposed three-phase strategy to implement BGRT in the clinic.

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/content/aapm/journal/medphys/34/10/10.1118/1.2779861
2007-09-11
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: BGRT: Biologically guided radiation therapy—The future is fast approaching!
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/10/10.1118/1.2779861
10.1118/1.2779861
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