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BGRT: Biologically guided radiation therapy—The future is fast
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Rapid advances in functional and biological imaging, predictive assays, and our understanding
of the molecular and cellular responses underpinning treatment outcomes herald the
coming of the long-sought goal of implementing patient-specific biologically guided
therapy (BGRT) in the clinic. Biological imaging and predictive assays have the potential to
provide patient-specific, three-dimensional information to characterize the radiation response
characteristics of tumor and normal structures. Within the next decade, it will be
possible to combine such information with advanced delivery technologies to design and deliver
biologically conformed, individualized therapies in the clinic. The full implementation of
BGRT in the clinic will require new technologies and additional research. However, even
the partial implementation of BGRT treatment planning may have the potential to substantially impact
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