Receptor-ligand compartment model.
Example of (A) the inputs and (B) the SMS model output when the protocol A is applied.
Sum of the squared differences between the SMS output and the COMKAT and DSM outputs as a function of the radionuclide half life (log scale). The results for the three injection protocols studied are shown. The horizontal dashed line indicates the statistical threshold. Values over this threshold indicate significant difference (KS test) in the model output of the COMKAT and/or the DSM models with respect to the SMS model.
Maximum receptor occupancy achieved by the labeled ligand in the protocol C as a function of the half life (log scale). For a fixed administered activity and a fixed specific activity , the longer the half life the higher the maximum labeled receptor occupancy achieving almost 100% with the long half life radionuclides.
Determination of the scale factor of the noise model. Circles are the absolute value of the fitted model to the PET data minus the PET data. Plus symbols are the absolute value of the noise model with the proper value for (0.08).
State variables and input functions.
Injection protocols used in the computational simulations.
Common radionuclide used in PET.a
Expression of COMKAT and DSM model in terms of labeled and unlabeled variables.
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