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Validity of model approximations for receptor-ligand kinetics in nuclear medicine
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10.1118/1.2719569
/content/aapm/journal/medphys/34/5/10.1118/1.2719569
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/5/10.1118/1.2719569

Figures

Image of FIG. 1.
FIG. 1.

Receptor-ligand compartment model.

Image of FIG. 2.
FIG. 2.

Example of (A) the inputs and (B) the SMS model output when the protocol A is applied.

Image of FIG. 3.
FIG. 3.

Sum of the squared differences between the SMS output and the COMKAT and DSM outputs as a function of the radionuclide half life (log scale). The results for the three injection protocols studied are shown. The horizontal dashed line indicates the statistical threshold. Values over this threshold indicate significant difference (KS test) in the model output of the COMKAT and/or the DSM models with respect to the SMS model.

Image of FIG. 4.
FIG. 4.

Maximum receptor occupancy achieved by the labeled ligand in the protocol C as a function of the half life (log scale). For a fixed administered activity and a fixed specific activity , the longer the half life the higher the maximum labeled receptor occupancy achieving almost 100% with the long half life radionuclides.

Image of FIG. 5.
FIG. 5.

Determination of the scale factor of the noise model. Circles are the absolute value of the fitted model to the PET data minus the PET data. Plus symbols are the absolute value of the noise model with the proper value for (0.08).

Tables

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TABLE I.

State equations.

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TABLE II.

State variables and input functions.

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TABLE III.

Injection protocols used in the computational simulations.

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TABLE IV.

Common radionuclide used in PET.a

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TABLE V.

Model parameters.

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TABLE VI.

Expression of COMKAT and DSM model in terms of labeled and unlabeled variables.

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/content/aapm/journal/medphys/34/5/10.1118/1.2719569
2007-04-23
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Validity of model approximations for receptor-ligand kinetics in nuclear medicine
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/34/5/10.1118/1.2719569
10.1118/1.2719569
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