Schematic diagram of a CAD system for medical image interpretation.
Publications on or related to CAD in Medical Physics.
Components within the “black box” of a CAD system.
Difference-image approach to detecting nodule candidates on chest radiographs. The approach aimed to enhance the nodule with one processing filter and to suppress the anatomical background with another processing filter, with the difference resulting in an image for further analysis. Reprinted with permission from Giger et al. 1988 (Ref. 21).
ROC curves illustrating statistically significant improvement in radiologists’ detection of microcalcification clusters when a computer aid is used. Level 1 corresponds to use of the computer having a performance level of 87% true-positive rate and an average of four false-positive clusters per image. Level 2 corresponds to use a computer aid with the same 87% true-positive rate but a simulated average false-positive cluster rate of only one false-positive cluster per image. Reprinted with permission from Chan et al. (Ref. 114).
(a) First prototype CADe system—developed for screening mammography at the University of Chicago (circa 1994); (b) system annotated output on thermal paper.
Computer/human interface for a multimodality workstation with computer outputs in numerical, pictorial, and graphical modes for both (a) mammography CADx output and (b) sonography CADx output.
Three empirical ROC curves with area under the ROC curve (AUC) values of 0.917, 0.825, and 0.862. The partial area values are 0.817, 0.484, and 0.261, respectively, for a sensitivity threshold 0.90. It is apparent that ROC (1), with its high partial area index, corresponds to a high sensitivity at high specificity (1-FPF). Reprinted with permission from Jiang et al. (Ref. 323).
Prospective clinical trial of commercial CADe systems for screening mammography. These studies used a sequential reading design in which the interpretations by the same radiologist without CADe immediately followed by with CADe were recorded for individual cases. The results were, therefore, collected from the same patient cohorts and the same radiologists.
Prospective clinical trial of commercial CADe systems for screening mammography. These studies compared the statistical results by a group of radiologists over two periods of time before and after CADe was implemented in the practice. The patient cohorts were different and the radiologists may not be the same.
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