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Fourier transform infrared imaging and small angle x-ray scattering as a combined biomolecular approach to diagnosis of breast cancer
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10.1118/1.2890391
/content/aapm/journal/medphys/35/5/10.1118/1.2890391
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/35/5/10.1118/1.2890391
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

The H&E image, UHCA maps, and spectra of (a) cancerous tissue, (b) normal tissue, (c) fibroadenoma, and (d) inflammation.

Image of FIG. 2.
FIG. 2.

(a) Comparison of the spectra from normal tissue (dashed line) and cancer tissue (solid) with inset showing close-up views of the collagen triplet and surrounding features. (b) Second derivative data of (a).

Image of FIG. 3.
FIG. 3.

The results of the SAXS testing. This shows a comparison of the two-dimensional scattering pattern between (b) a normal breast sample, (c) a breast cancer sample, and (a) one collagen control (rat tail). (d) is a representation of the spacing vs the scatter intensity/area of the third axial peak and (e) represents the fifth axial peak. After viewing the H&E slides and basing overall sample composition on the one section, the samples are characterized as normal , mainly fat , cancer , or mucinous cancer .

Image of FIG. 4.
FIG. 4.

Scatter plot combining elements from FTIR and SAXS data. The horizontal axis shows first derivative values at , depicting the shape of the collagen triplet. The vertical axis depicts the intensity of the fifth axial peak obtained from SAXS images. The samples are characterized as normal , mainly fat , cancer , or mucinous cancer .

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/content/aapm/journal/medphys/35/5/10.1118/1.2890391
2008-04-29
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Fourier transform infrared imaging and small angle x-ray scattering as a combined biomolecular approach to diagnosis of breast cancer
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/35/5/10.1118/1.2890391
10.1118/1.2890391
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