Molecular imaging and the unification of multilevel mechanisms and data in medical physics
The case of RA where various imaging modalities are used to provide details at different levels of information.
The advent of MI allows the design of structured experiments aiming to reveal/find the causal relationships among variables and mechanisms concerning various levels of biological organization. A unified biomedical theory may be built using top-down and bottom-up approaches (as well as combinations thereof) for diagnosis or prognosis. This theory could causally connect the mutations of specific genes (sequence analysis) with a characteristic pattern of gene coexpressions (analysis of microarrays), the abnormal value of some immunochemical parameters (flow cytometry, microscopy), the manifestation of certain macroscopic anatomical or functional anomalies (CT, SPECT, etc.) and finally with the observation of specific clinical signs and symptoms. All modalities are in vivo unless otherwise indicated.
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