MicroCT PMMA anesthesia support module. Radiation exposures were defined for microCT scans when conducted with and without the use of the microCT PMMA anesthesia support module. The anesthesia module provides gas anesthesia under a HEPA filtered pathogen-free environment.
Calibration curve to convert TLD output into radiation dose. We used this calibration plot to determine the exposure response of the TLD chips which was . This calculation allowed us to convert TLD output into radiation dose for the remainder of the experiments.
C/kg delivered per radiograph. This graph shows the charge imparted to the field of view isocenter as a function of radiograph acquisition angle. The radiation dose is relatively constant from angle of acquisition, but then decreases from . This reduction is due to the plastic animal bed within the anesthesia module which absorbs some of the x-ray dose and therefore reduces the radiation exposure measured by the CT probe ion chamber.
C/kg delivered as a function of kVp. This graph shows the linear relationship between dose and kVp setting of the x-ray source. As the kVp increases, the dose increases linearly. For all three conditions, the slopes of the lines are very similar confirming that TLD radiation measurements are comparable to ion chamber measurements.
MicroCT images of implanted TLDs. MicroCT reconstructed images highlighting the precise locations of implanted TLDs. Figure shows (A) a sagittal microCT slice, (B) a coronal microCT slice, and (C) the axial microCT slice corresponding to the intersected lines in (A) and (B).
Internal adsorbed doses of different mouse organs. Table I provides the dose measured following a single microCT scan by TLD chips implanted in various organs in a mouse. Radiation dose was measured employing a typical microCT scan protocol. The average absorbed dose over all measurements to the organs is .
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