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Mass preserving nonrigid registration of CT lung images using cubic B-spline
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10.1118/1.3193526
    + View Affiliations - Hide Affiliations
    Affiliations:
    1 Department of Mechanical and Industrial Engineering, and IIHR–Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242
    2 Department of Radiology, Department of Biomedical Engineering, and Department of Medicine, The University of Iowa, Iowa City, Iowa 52242
    3 Department of Mechanical and Industrial Engineering, and IIHR–Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242
    a) Founder and shareholder of VIDA Diagnostics which is commercializing some of the software utilized in this work.
    b) Electronic mail: ching-long-lin@uiowa.edu
    Med. Phys. 36, 4213 (2009); http://dx.doi.org/10.1118/1.3193526
/content/aapm/journal/medphys/36/9/10.1118/1.3193526
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/36/9/10.1118/1.3193526

Figures

Image of FIG. 1.
FIG. 1.

Framework of the multiresolution strategy.

Image of FIG. 2.
FIG. 2.

Locations of the landmarks (marked by spheres) at (a) TLC and (b) FRC for registration pair A. Surface rendering of five lobes and major vessel branches is shown for reference.

Image of FIG. 3.
FIG. 3.

Distribution of landmark distance along the axis (from apex to base) (a) before and (b) after registrations using the SSTVD method (filled diamond) and the SSD method (unfilled circle) for registration pair A. Note that all landmarks have an approximately uniform error distribution from apex to base for the SSTVD method while they have a large deviation of error for the SSD method in (b).

Image of FIG. 4.
FIG. 4.

Surface distance maps of the warped TLC major vessel tree to the FRC major vessel tree for the (a) SSTVD method and the (b) SSD method. The FRC major vessel tree is shown in white for reference. Note that the red segments in (a) are caused by missing segments in FRC major tree, not by mis-registration. Examples are marked as A and B. Segments with large errors in (b), marked as C, D, and E, are due to clear mis-registration, as one can easily see that the white unwarped segments misalign with the color coded tree.

Image of FIG. 5.
FIG. 5.

A slice from the registration pair A. (a) Slice from the reference image. (b) Corresponding slice from the warped image with the SSTVD method. (c) Corresponding slice from the warped image with the SSD method. Notice a misalignment of vessel trees indicated by the arrow for the SSD method in (c).

Image of FIG. 6.
FIG. 6.

A slice from the registration pair F. (a) Slice from the reference image. (b) Corresponding slice from the warped image with the SSTVD method. (c) Corresponding slice from the warped image with the SSD method. Notice the good alignment between the lobar fissures (highlighted in lines) and between the vessel trees for the SSTVD method in (b), while an obvious misalignment of the fissure and vessels for the SSD method in (c).

Tables

Generic image for table
TABLE I.

The TLV, AV, and TV for all six registration pairs are estimated from the HU based on quantitative CT measures. The percentage change in the tissue volume is also listed for reference. The unit for volumes is liter (l).

Generic image for table
TABLE II.

Statistical comparison of landmark errors between the SSTVD method, the SSD method, and the MI method for all six registration pairs.

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/content/aapm/journal/medphys/36/9/10.1118/1.3193526
2009-08-17
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Mass preserving nonrigid registration of CT lung images using cubic B-spline
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/36/9/10.1118/1.3193526
10.1118/1.3193526
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