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Quantitative analysis of breast parenchymal patterns using 3D fibroglandular tissues segmented based on MRI
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10.1118/1.3271346
/content/aapm/journal/medphys/37/1/10.1118/1.3271346
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/1/10.1118/1.3271346

Figures

Image of FIG. 1.
FIG. 1.

Three case examples are demonstrated, including one fatty breast (top row), one Type I case (intermingled pattern, middle row), and one Type C case (central pattern, bottom row). For each case, five axial view MR images from five imaging slices selected from superior to inferior directions are shown. There are no breast lesions on these images. The percent density is 5.4% for the fatty breast, 14.1% for the Type I case, and 13.9% for the Type C case.

Image of FIG. 2.
FIG. 2.

The bar plot for comparing the (a) age, (b) fibroglandular tissue volume, and (c) the percent density among three subject groups. The fatty breast group (indicated as Type F) is significantly older, and has the smallest fibroglandular tissue volume and the lowest percent density compared to the intermingled type (Type I) and the central type (Type C). The Type I and Type C groups have comparable age, fibroglandular tissue volume, and the percent density, thus they cannot be separated based on these parameters.

Image of FIG. 3.
FIG. 3.

Illustration of the calculation of the circularity and the convexity index. Only one slice is shown here as an example, but the analysis was performed in 3D. For circularity, a sphere with effective diameter is drawn, and the ratio between the fibroglandular tissue volume within the sphere and the total fibroglandular tissue volume is calculated as the circularity index. The intermingled pattern (top) has a circularity index of 0.42 and the central pattern (bottom) has a higher index of 0.86. For convexity, the minimum convex hull is drawn, and the ratio between the total fibroglandular tissue volume and the convex hall volume is calculated as the convexity index. The intermingled pattern (top) has a convexity index of 0.36 and the central pattern (bottom) has a higher index of 0.73.

Image of FIG. 4.
FIG. 4.

Histogram of four morphological parameters differentiating the intermingled pattern (Type I, dashed curve) and the central pattern (Type C, solid curve), (a) circularity index, (b) convexity index, (c) irregularity index, and (d) compactness index. The intermingled pattern group has lower circularity and convexity, and higher irregularity and compactness compared to the central pattern group. The cases with high and low indices are illustrated in Figs. 5–8.

Image of FIG. 5.
FIG. 5.

The circularity index is sensitive to the spherical vs nonspherical shapes. The top case is an intermingled pattern with percent and circularity , ranking 33 in all 230 cases. The bottom case is a central pattern with a similar percent , and a higher circularity , ranking 187 in all 230 cases.

Image of FIG. 6.
FIG. 6.

The convexity index is sensitive to the convex vs concave shapes. The top case is an intermingled pattern with percent and convexity , ranking #30 in all 230 cases. The bottom case is a central pattern with percent , and a higher convexity , ranking #180 in all 230 cases.

Image of FIG. 7.
FIG. 7.

The irregularity index is sensitive to the irregular vs smooth margins. The top case is an intermingled pattern with percent and irregularity , ranking #190 in all 230 cases. The bottom case is a central pattern with percent , and a lower irregularity , ranking #26 in all 230 cases.

Image of FIG. 8.
FIG. 8.

The compactness index is sensitive to both shape and margin. Round shape with smooth margin has a relatively low compactness index. The top case is an intermingled pattern with percent and compactness , ranking #180 in all 230 cases. The bottom case is a central pattern with the percent , and a lower compactness , ranking #32 in all 230 cases.

Image of FIG. 9.
FIG. 9.

The ROC curves. When only using the compactness index the AUC is 0.84, and when using all four morphology parameters combined, the AUC is improved to 0.94.

Tables

Generic image for table
TABLE I.

Comparison of age, fibroglandular tissue volume, percent density, and morphological parameters between two groups with intermingled pattern and central pattern.

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/content/aapm/journal/medphys/37/1/10.1118/1.3271346
2009-12-09
2014-04-24
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Quantitative analysis of breast parenchymal patterns using 3D fibroglandular tissues segmented based on MRI
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/1/10.1118/1.3271346
10.1118/1.3271346
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