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A grating-based single-shot x-ray phase contrast and diffraction method for in vivo imaging
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Image of FIG. 1.
FIG. 1.

Layout of the imaging device. From left to right: The x-ray tube, a set of glass beads (object), lead grid, and camera’s image plane.

Image of FIG. 2.
FIG. 2.

Retrieval of harmonic images and differential phase contrast in the spatial frequency domain. (a) Raw image. The Moiré pattern in this image is due to subsampling to reduce the size of the figure for publication. (b) 2D spatial spectrum of raw image, (c) first-order harmonic image, and (d) zeroth-order (absorption) image.

Image of FIG. 3.
FIG. 3.

Glass beads at different distances from the x-ray source. Top row: Absorption images for and 12 cm. Bottom row: Differential phase contrast images for and 12 cm.

Image of FIG. 4.
FIG. 4.

Differential phase contrast images of glass beads acquired at the last three system geometry settings listed in Table I. Top row: Images without camera correction with the grid set at three different distances from the camera. Bottom row: Images at the same distances but with correction for the camera’s point spread function.

Image of FIG. 5.
FIG. 5.

The differential phase contrast signal at the top and bottom edges of the glass beads as a function of the grid-to-camera distance , with and without camera’s PSF correction. The extraneous phase at low values was an effect of the camera’s point spread function. The error bars indicate 1 standard deviation.

Image of FIG. 6.
FIG. 6.

Mouse snout taken ex vivo with correction for camera PSF; (a) absorption image, (b) diffraction image, and (c) DPC image.

Image of FIG. 7.
FIG. 7.

Images of rat paws taken in vivo, with camera’s PSF correction. (a) Back paw, absorption image; (b) back paw, diffraction image; (c) back paw, DPC image; (d) front paw, absorption image; (e) front paw, diffraction image; and (f) front paw, DPC image.

Image of FIG. 8.
FIG. 8.

X-ray absorption vs. diffraction in the bone sections of the rat foot images. Error bars show one standard deviation.


Generic image for table

Design criteria and phase multiplier for the grid and object placements that were tested.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: A grating-based single-shot x-ray phase contrast and diffraction method for in vivo imaging