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Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breasta)
a)Conflict of interest: The Mayo Foundation and two of the authors of this work (M.K. O’Connor and C.B. Hruska) obtain royalties from licensing arrangements between the Mayo Foundation and Gamma Medica-Ideas.
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10.1118/1.3512759
/content/aapm/journal/medphys/37/12/10.1118/1.3512759
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/12/10.1118/1.3512759

Figures

Image of FIG. 1.
FIG. 1.

(a) Estimated cumulative cancer incidence attributed to annual screening performed from ages 40 to 80 for digital mammography at a MGD of 3.91 mGy, screen-film mammography at a MGD of 4.98 mGy, MBI/BSGI using 925 MBq Tc-99m sestamibi, and PEM using 370 MBq F-18 FDG. (b) Estimated cumulative cancer mortality attributed to annual screening performed from ages 40 to 80 for digital mammography at a MGD of 3.91 mGy, screen-film mammography at a MGD of 4.98 mGy, MBI/BSGI using 925 MBq Tc-99m sestamibi, and PEM using 370 MBq F-18 FDG.

Image of FIG. 2.
FIG. 2.

(a) Estimated cumulative cancer incidence attributed to annual screening performed from ages 50 to 80 for digital mammography at a MGD of 3.91 mGy, screen-film mammography at a MGD of 4.98 mGy, MBI/BSGI using 925 MBq Tc-99m sestamibi, and PEM using 370 MBq F-18 FDG. (b) Estimated cumulative cancer mortality attributed to annual screening performed from ages 50 to 80 for digital mammography at a MGD of 3.91 mGy, screen-film mammography at a MGD of 4.98 mGy, MBI/BSGI using 925 MBq Tc-99m sestamibi, and PEM using 370 MBq F-18 FDG.

Image of FIG. 3.
FIG. 3.

(a) Estimated cumulative cancer incidence from natural background radiation (3.1 mSv/yr from ages 0 to 80). The comparable cancer incidence attributed to digital mammography (3.91 mGy) and MBI/BSGI (925 MBq Tc-99m sestamibi) performed annually from ages 40 to 80 are also shown. (b) Estimated cumulative cancer mortality from natural background radiation (3.1 mSv/yr from ages 0 to 80). The comparable cancer mortality attributed to digital mammography (3.91 mGy) and MBI/BSGI (925 MBq Tc-99m sestamibi) performed annually from ages 40 to 80 are also shown. (c) Estimated cumulative cancer mortality from all sources (National Program of Cancer Registries) and from natural background radiation (3.1 mSv/yr from ages 0 to 80). Estimated cancer mortality attributed to digital mammography (3.91 mGy) and MBI/BSGI (925 MBq Tc-99m sestamibi) performed annually from ages 40 to 80 are also shown.

Tables

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TABLE I.

Number of female survivors from ages 0 to 84, starting with a population of 100 000. Data taken from The Human Mortality Database (Ref. 21).

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TABLE II.

Values of and used for estimation of EAR (cancer incidence) due to mammography, MBI, BSGI, and PEM. Values were extracted from BEIR VII (Table 12-2).

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TABLE III.

Values of , , and used for estimation of EAR (incidence and mortality) due to background radiation. Values were extracted from BEIR VII (Table 12-1).

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TABLE IV.

Estimated lifetime cumulative risk of radiation-induced cancer (incidence and mortality) attributed to a single examination at ages 40, 50, 60, and 70 yr of age using various breast imaging procedures. All numbers are cumulative to age 80 for 100 000 females undergoing a single examination.

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TABLE V.

Using breast cancer incidence and mortality for different age groups and corresponding observed breast cancer mortality rate for 2006 [from the National Program of Cancer Registries (Ref. 21)], the table shows estimated cancer mortality rate calculated using Eq. (1.5) and the corresponding total mortality that would be observed in the absence of screening mammography. All numbers are cumulative to age 80 for 100 000 females.

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TABLE VI.

Using breast cancer incidence for 2006 [from the National Program of Cancer Registries (Ref. 21)] and assuming 25% women have dense breast tissue, with fivefold increase in risk of breast cancer, the table shows estimated cancer incidence in a population of 100 000 women with dense breasts. The mortality rate was assumed to be the same as in Table V. All numbers are cumulative to age 80 for 100 000 females.

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TABLE VII.

Estimated cumulative cancer incidence and mortality attributed to various breast imaging procedures and background radiation, compared to the potential number of lives saved assuming a 15%, 14%, and 32% reduction in mortality from screening mammography for a normal population of women aged 40–49, 50–59, and 60–80, respectively, and assuming a 15% reduction for all women aged 40–80 with dense breast tissue.

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/content/aapm/journal/medphys/37/12/10.1118/1.3512759
2010-11-10
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breasta)
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/12/10.1118/1.3512759
10.1118/1.3512759
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