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Evaluation of respiration-correlated digital tomosynthesis in lunga)
a)Memorial Sloan-Kettering Cancer Center has a research agreement with Varian Medical Systems.
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10.1118/1.3312276
/content/aapm/journal/medphys/37/3/10.1118/1.3312276
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/3/10.1118/1.3312276

Figures

Image of FIG. 1.
FIG. 1.

Schematic illustrating DTS acquisition. Dashed arcs indicate x-ray source and detector trajectories. Dashed horizontal lines indicate reconstruction planes at varying depths in the patient.

Image of FIG. 2.
FIG. 2.

Schematic illustrating differences between standard DTS and RC DTS. Dashed circle shows the x-ray source trajectory, solid curve at 12 o'clock position indicates the optimal arc for DTS reconstruction without respiration correlation. Dashed radial lines at 11 and 1 o'clock positions indicate x-ray directions of two DTS disjoint arcs within a respiration phase bin (over two breathing cycles) that are chosen for RC-DTS reconstruction.

Image of FIG. 3.
FIG. 3.

Images of a head phantom. (a) DTS image of static phantom. (b) Standard DTS image (without respiration correlation) of a moving phantom. (c) RC-DTS image at end-exhalation phase. (d) RC-DTS image in midexhalation phase. [(e)–(h)] CBCT images corresponding to (a)–(d), respectively.

Image of FIG. 4.
FIG. 4.

[(a)–(e)] DTS and [(f)–(j)] CBCT images of a lung tumor (patient 1) attached to a diaphragm. Images are viewed from posterior direction. [(a) and (f)] Standard reconstruction without respiration correlation. Other images are respiration-correlated [(b) and (g)] at midinhalation, [(c) and (h)] at end inhalation, [(d) and (i)] at midexhalation, and [(e) and (j)] at end exhalation. Dashed lines are a visual aid to indicate tumor motion. Arrows (f) indicate tumor and structure in the lung.

Image of FIG. 5.
FIG. 5.

Posterior view DTS (upper row) and CBCT (lower row) images of patient 4: [(a) and (f)] Without respiration correlation, [(b) and (g)] at end inhalation, [(c) and (h)] at midexhalation, [(d) and (i)] at end exhalation, and [(e) and (j)] at midinhalation.

Image of FIG. 6.
FIG. 6.

Right lateral DTS (upper row) and CBCT (lower row) images of patient 4: [(a) and (f)] Without respiration correlation, [(b) and (g)] at end inhalation, [(c) and (h)] at midexhalation, [(d) and (i)] at end exhalation, and [(e) and (j)] at midinhalation. Respiration correlation is based on patient’s RPM trace.

Image of FIG. 7.
FIG. 7.

Left posterior oblique DTS (upper row) and CBCT (lower row) images of patient 4: [(a) and (f)] Without respiration correlation, [(b) and (g)] at end inhalation, [(c) and (h)] at midexhalation, [(d) and (i)] at end exhalation, and [(e) and (j)] at midinhalation. Respiration correlation is based on patient’s RPM trace.

Image of FIG. 8.
FIG. 8.

Displacement of tumor from end exhalation in RC-DTS vs RC-CBCT for patients 1– 6. Three displacements per patient were determined from image registration between the reference image at end exhalation and images at midinhalation, end inhalation, and midexhalation. Plots in the upper row show patients with the tumor attached to the diaphragm, plots in the lower row show all other patients. Dashed lines along diagonal of each plot indicate exact agreement between RC-DTS and RC-CBCT, whereas dashed lines on either side of the diagonal indicate the boundaries of agreement within 2 mm. Error bars represent the repeatability of the displacement determination.

Image of FIG. 9.
FIG. 9.

Tumor displacement relative to room isocenter between two imaging sessions for patients 1–5 and 7 (see Table I for time between scans). Horizontal axes show displacement measured from registration of RC-CBCT images at end-exhalation and vertical axes show corresponding displacement measured from RC-DTS. Dashed lines along diagonal of each plot indicate exact agreement between RC-DTS and RC-CBCT, whereas dashed lines on either side of the diagonal indicate the boundaries of agreement within 2 mm. Error bars represent the repeatability of the displacement determination.

Image of FIG. 10.
FIG. 10.

Tumor centroid position (relative to room isocenter) as determined from RC-DTS vs RC-CBCT for patients 1–6 at each phase (4 data points per patient) (a) in the LR direction, (b) in the SI direction, and (c) in the AP direction. Dashed black line indicates exact agreement between RC-DTS and RC-CBCT. Plots (d), (e), and (f) are the difference in tumor centroid position . Error bars represent the intraobserver reproducibility in the DTS-to-CBCT registration. Error bars are shown for the end-expiration data points only and are of similar magnitude for the other phases.

Tables

Generic image for table
TABLE I.

Characteristics of patients who participated in the study. Description of tumor location, tumor size, motion amplitude, and time between the consecutive scans are given. Patient 4 had two tumors. Displacement data are deduced from RC-CBCT registration, except for patient 7 when tumor motion was visually estimated on RC-CBCT scans.

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/content/aapm/journal/medphys/37/3/10.1118/1.3312276
2010-02-23
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Evaluation of respiration-correlated digital tomosynthesis in lunga)
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/3/10.1118/1.3312276
10.1118/1.3312276
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