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Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D-conformal or intensity-modulated radiation therapya)
a)Presented at the 50th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, Massachusetts, 21–25 September 2008.
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10.1118/1.3451125
/content/aapm/journal/medphys/37/7/10.1118/1.3451125
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/7/10.1118/1.3451125

Figures

Image of FIG. 1.
FIG. 1.

[(a), top] Prostate volume vs mean dose to rectum with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose to rectum increases with the increase in the volume of prostate for both 3D and IMRT plans . [(b), bottom] Prostate volumes vs dose to 30% rectum with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose and dose to 30% rectum increases with the increase in the volume of prostate for both 3D and IMRT plans . Dose to rectum with 3D plans is lower than that with IMRT plans for prostate volumes less than , where the 3D slope crosses the IMRT slope.

Image of FIG. 2.
FIG. 2.

[(a), top] volumes vs mean dose to rectum with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose to rectum increases with the increase in the volume of for both 3D and IMRT plans . [(b), bottom] volumes vs dose to 30% rectum with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Dose to 30% rectum increases with the increase in the volume of for both 3D and IMRT plans . Dose to 30% rectum with 3D plans is lower than that with IMRT plans for volumes less than , where the 3D slope crosses the IMRT slope.

Image of FIG. 3.
FIG. 3.

[(a), top] Prostate volume vs mean dose to bladder with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose to bladder increases with the increase in the volume of prostate for both 3D and IMRT plans . Dose to bladder with 3D plans is lower than that with IMRT plans. [(b), bottom] Prostate volume vs dose to 30% bladder with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose and dose to 30% bladder increases with the increase in the volume of prostate for both 3D and IMRT plans . Dose to 30% bladder with 3D plans is lower than that with IMRT plans for prostate volumes , where the 3D and IMRT slopes cross.

Image of FIG. 4.
FIG. 4.

[(a), top] volumes vs mean dose to bladder with actual (diamonds, ) and rescaled (triangles, dashed line, ) 3D and IMRT plans (squares, ). Mean dose to rectum with 3D plans is lower than that with IMRT plans. [(b), bottom] volumes vs dose to 30% bladder with actual (diamonds, ) and rescaled (triangles, dashed lines, ) 3D and IMRT plans (squares, ). Mean dose and dose to 30% bladder increases with the increase in the volume of for both 3D and IMRT plans . Dose to 30% bladder with 3D plans is lower than that with IMRT plans for volumes less than , where the slopes of 3D and IMRT plans cross each other.

Image of FIG. 5.
FIG. 5.

The relationship between [(a), top)] prostate and [(b), bottom] volume vs 3D mean dose minus IMRT mean dose. In both plots, diamonds represent dose to rectum and squares represents dose to bladder. At zero on -axis, dose to rectum and bladder with 3D and IMRT are the same. Below zero, the minus sign before the dose (−200) indicates that dose to rectum or bladder is less than that with IMRT and vice versa. Prostate vs rectum: ; prostate vs bladder: ; vs rectum: ; and vs bladder: .

Image of FIG. 6.
FIG. 6.

[(a), top] Dose to 30% of rectum with 3D plans vs IMRT plans. The higher the dose to rectum with 3D plans, the higher also was the dose to rectum with IMRT plans . [(b), bottom] Dose to 30% of bladder with 3D plans vs IMRT plans. The higher the dose to bladder with 3D plans, the higher also was the dose to bladder with IMRT plans . .

Image of FIG. 7.
FIG. 7.

Prostate volume vs percent of 81 Gy delivered to 95% of CDPTV with 3D (diamonds) and IMRT (squares) plans. With the increase of prostate volume, the dose to CDPTV with 3D plans increases , while it decreases with IMRT plans .

Image of FIG. 8.
FIG. 8.

Prostate volume vs mean dose to CDPTV with 3D (diamonds) and IMRT (squares) plans. The mean dose to CDPTV increased with the increase in the CDPTV volume for 3D plans but not for IMRT plans .

Tables

Generic image for table
TABLE I.

Mean and range of structure volumes, , .

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TABLE II.

Mean dose to prostate, SV, and CDPTV and minimum and maximum dose in Gy to CDPTV with 3D and IMRT plans. Prescription dose was 81 Gy and .

Generic image for table
TABLE III.

Mean dose to rectum, bladder, and femur, and , , and for rectum and bladder with 3D and IMRT plans in Gy. , , and of rectum or bladder volumes receiving 30, 50, and 70 Gy with 3D and IMRT plans. Prescription dose was 81 Gy and . Dosimetry parameters of original 3D plans, without rescaling, are termed as actual dosimetry parameters in reference to rescaled dosimetry parameters.

Generic image for table
TABLE IV.

Comparison of mean dose to rectum with 3D and IMRT plans for patients with prostate volumes , 40.1–65, and , and volumes , 50.1–85, and , without and with 5% difference criteria. Less than 5% difference between 3D and IMRT plans in the mean doses is considered as not significantly different . For a given volume, the first and second lines are without and with 5% correction.

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2010-06-29
2014-04-21
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D-conformal or intensity-modulated radiation therapya)
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/7/10.1118/1.3451125
10.1118/1.3451125
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