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High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: Morphological and functional assessments
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10.1118/1.3467755
/content/aapm/journal/medphys/37/8/10.1118/1.3467755
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/8/10.1118/1.3467755

Figures

Image of FIG. 1.
FIG. 1.

(a) Photograph of the integrated hybrid x-ray/DOT system. The inset (right part) is a close-view photograph of the finger/fiber optics/x-ray interface. (b) Schematic of the interface. Note that both the Plexiglass container and finger tip holder can be translated horizontally for separate DOT and x-ray data acquisition. (c) The sagittal plane of a 3D DIP finger joint. (d) The coronal plane of a 3D DIP finger joint.

Image of FIG. 2.
FIG. 2.

Reconstructed images at selected coronal/sagittal sections for a typical OA finger joint: (a) Absorption slices along coronal sections; (b) absorption slices along sagittal sections; (c) scattering slices along coronal sections; (d) scattering slices along sagittal sections; and (e) tomographic x-ray image. The axes (left and bottom) indicate the spatial scale in millimeters, whereas the color scale gives the absorption or scattering coefficient in inverse millimeters.

Image of FIG. 3.
FIG. 3.

Reconstructed images at selected coronal/sagittal sections for a typical healthy finger joint: (a) Absorption slices along coronal sections; (b) absorption slices along sagittal sections; (c) scattering slices along coronal sections; (d) scattering slices along sagittal sections; and (e) tomographic x-ray image.

Image of FIG. 4.
FIG. 4.

Plot of the (a) absorption ratio, (b) scattering ratio, (c) combined image feature, and (d) mean joint space width over patient case number. Absorption coefficient of the joint tissues divided by that of the bone; scattering coefficient of the joint tissues divided by that of the bone; combined image ratio. (e) is the ROC curve for the four different classifiers. Structural joint space width.

Image of FIG. 5.
FIG. 5.

(a) Reconstructed absorption image at a selected coronal section and (b) scattering image at a selected sagittal section for a healthy joint with (left column) and without (right column) x-ray guidance.

Image of FIG. 6.
FIG. 6.

(a) Reconstructed absorption and (b) scattering image at a selected longitudinal plane for a simulation test with perfect (left column) and imperfect (right column) spatial information.

Tables

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TABLE I.

Statistical analysis showing the differences between OA and healthy subjects.

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/content/aapm/journal/medphys/37/8/10.1118/1.3467755
2010-07-28
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: Morphological and functional assessments
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/8/10.1118/1.3467755
10.1118/1.3467755
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