1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
QA procedures for multimodality preclinical tumor drug response testing
Rent:
Rent this article for
USD
10.1118/1.3464491
/content/aapm/journal/medphys/37/9/10.1118/1.3464491
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/9/10.1118/1.3464491

Figures

Image of FIG. 1.
FIG. 1.

Design of a multimodality tumor response phantom. The phantom is composed of five tumor-simulating test objects with different sizes. Five test objects have coaxial center at 10 mm from the phantom surface.

Image of FIG. 2.
FIG. 2.

Photograph of (a) multimodality phantom; [(b)–(d)] U.S., micro-CT, and T2 weighted MR images acquired in UTHSCSA; and [(e)–(g)] U.S., micro-CT, and T2 weighted MR images acquired in UC Denver. Directions of three perpendicular dimensions [short (x), long (y), and depth (z)] according to a Cartesian coordinate system was specified in (a).

Image of FIG. 3.
FIG. 3.

Comparison of imaging and gold standard size data of the phantom in UTHSCSA. Plotting the phantom [(a)–(c)] design diameter and (d) volume vs the respective imaging-derived parameters provide the correction equations to eliminate systematic imaging error. Short axis and long axis represent the directions parallel to the width and the length of the phantom, respectively. Depth is the axis perpendicular to the two axes. Perfect agreement gives a slope of 1.0000 and an intercept of 0.0000.

Image of FIG. 4.
FIG. 4.

Comparison of imaging and gold standard size data of the phantom in UC Denver using the measurement protocols provided by UTHSCSA.

Tables

Generic image for table
TABLE I.

TM materials used for test objects and background of the tumor response phantom.

Generic image for table
TABLE II.

Imaging protocols used to scan the tumor response phantom in UTHSCSA and UC Denver.

Generic image for table
TABLE III.

Multimodality phantom tumor size measurement worksheet. Institution: ___________________________________ Date: _______________________________________ QA Consultant: _______________________________

Generic image for table
TABLE IV.

Slopes and intercepts of linear regression lines for diameters of test objects in three perpendicular dimensions measured at UTHSCSA and UC Denver. In parentheses, 95% confidence intervals are shown. Short axis and long axis represent the direction parallel to the width and the length of the phantom, respectively. Depth is the axis perpendicular to the two axes.

Generic image for table
TABLE V.

RECIST and WHO analysis for size measurement of test objects in the tumor response phantom. For RECIST analysis, the longest diameters in the transverse plane were added for five test objects. In WHO analysis, the product of a longest diameter and a longest perpendicular diameter in the transverse plane were added for five test objects. Mean and standard deviation were calculated for three repeated measures. In parentheses, % errors for mean and standard deviation are shown.

Generic image for table
TABLE VI.

Volume calculated from diameter measurements for each test object. An equation , where a, b, and c are longest diameters in three perpendicular dimensions, was used. Mean and standard deviation were calculated for three repeated measures. In parentheses, % errors for mean and standard deviation are shown.

Loading

Article metrics loading...

/content/aapm/journal/medphys/37/9/10.1118/1.3464491
2010-08-19
2014-04-25
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: QA procedures for multimodality preclinical tumor drug response testing
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/37/9/10.1118/1.3464491
10.1118/1.3464491
SEARCH_EXPAND_ITEM