Diagram of a typical signal time curve illustrating how the last fitted point for the gamma variate was selected for each method: (i) third point after the bolus minimum, (ii) point of the half drop of the bolus after the bolus minimum, (iii) the point after the minimum at which the signal exceeds the post bolus signal minus the standard deviation of the pre bolus signal (σ) and (iv) by visual determination.
Example of the bolus (solid line) and recirculation (dotted line) portions of the SCR model and bolus (dashed line) of a GV fitted to a typical concentration time curve (crosses).
Fits (line) to concentration time curves (crosses). The left column gives the “noiseless” concentration time curves and the right has added noise to give an SNR of 25.
Percent error (a) and percent deviation (b) of the AUC plotted against SNR for each model. Percent error (c) and percent deviation (d) of the FM plotted against SNR for each model.
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