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Restricted maximum likelihood estimation of PET neuroreceptor occupancy in the absence of a reference region
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10.1118/1.3578606
/content/aapm/journal/medphys/38/5/10.1118/1.3578606
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/38/5/10.1118/1.3578606

Figures

Image of FIG. 1.
FIG. 1.

Mean bias and efficiency of OLS and occupancy REML depending on the true occupancy, the amount of noise, and the number of ROIs. REML 1 = restricted maximum likelihood estimator in designs with one postdose scan; REML 2 = restricted maximum likelihood estimator in designs with two postdose scans; OLS = ordinary least squares; ROI = region of interest. Mean bias (top row) and efficiency (bottom row) of the estimators depending on the true occupancy (left), the amount of noise (center), and the number of ROIs (right). Error bars in bias plots represent the standard deviation of the estimator (i.e., the square root of the mean variance). Efficiency bars larger than 300% have been truncated to 300% for graphical purposes.

Tables

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TABLE I.

Bias, variance, and efficiency of the different occupancy estimators.

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/content/aapm/journal/medphys/38/5/10.1118/1.3578606
2011-05-05
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Restricted maximum likelihood estimation of PET neuroreceptor occupancy in the absence of a reference region
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/38/5/10.1118/1.3578606
10.1118/1.3578606
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