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Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy
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10.1118/1.3668059
/content/aapm/journal/medphys/39/1/10.1118/1.3668059
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/1/10.1118/1.3668059

Figures

Image of FIG. 1.
FIG. 1.

QA Passing rate as a function of the average number of MU/segment for 60 biological-based VMAT plans including the 24 SBRT plans (square) of the study.

Image of FIG. 2.
FIG. 2.

CI, CN, and Rx/PTV50 as a function of the maximum dose to the target in percentage of the prescription dose.

Image of FIG. 3.
FIG. 3.

Dose distribution for a VMAT SBRT prostate plan (patient 5) with axial (top), coronal (left), and sagittal (right) views. Isodose lines shown are 112%, 105%, 100%, 80%, 60%, and 40% of the prescription dose. The dose distribution avoids the bladder, the urethra, and the rectum.

Image of FIG. 4.
FIG. 4.

Dose distribution for a VMAT SBRT lung plan (patient 14) with axial (top), coronal (left), and sagittal (right) views. Isodose lines shown are 112%, 105%, 100%, 80%, 60%, and 40% of the prescription dose. The high and intermediate dose distributions avoid the stomach, the heart, and the esophagus.

Image of FIG. 5.
FIG. 5.

Dose distribution for a VMAT SBRT liver plan (patient 17) with axial (top), coronal (left), and sagittal (right) views. Isodose lines shown are 112%, 105%, 100%, 80%, 60%, and 40% of the prescription dose.

Image of FIG. 6.
FIG. 6.

Comparison of biological-based and physical plans for prostate patient 5.

Image of FIG. 7.
FIG. 7.

Comparison of biological-based and physical plans for lung patient 14.

Image of FIG. 8.
FIG. 8.

Comparison of biological-based and physical plans for liver patient 17.

Tables

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TABLE I.

Delivery parameters for biological-based VMAT SBRT plans.

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TABLE II.

Treatments duration, QA passing rates, and conformation numbers.

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TABLE III.

Relevant cost functions for each disease sites with the biological parameters used for three different patients that were replanned using physical constraints. The resulting EUD for the biological-based plan and the physical plan are also reported.

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/content/aapm/journal/medphys/39/1/10.1118/1.3668059
2011-12-20
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/1/10.1118/1.3668059
10.1118/1.3668059
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