The experimental diagrams of the (a) Standard, (b) Rust, and (c) MGH methods, including the injection time-line, time-dependence of MBF, blood and tissue time-activity curves and the compartment models. Note that the MGH method shares the same experimental design with the Rust model, but the model configuration is different.
The sensitivity analysis of K 1 as a function of study duration and k 3. The error bars represent the SD estimated from the covariance matrix. (a) K 1 as a function of study duration. (b) K 1 as a function of k 3.
Bar graphs for the estimated MBF when dipyridamole is used as the stressor. The second tracer injection dose is equal to the first tracer dose. On the x-axis, the number 1–3 denote the simulation performed based on different representative subjects.
Plots of the average bias calculated from the MBF estimated with MGH1 and MGH2 models using the MBF from the stress-only as reference. The mean bias is computed by pooling the same region over the subjects.
Plots of the average SD calculated from the MBF estimated with MGH1 and MGH2 models using the MBF from the stress-only as reference. The mean SD is computed by pooling the same region over the subjects.
Representative rest/stress 18F-Flurpiridaz PET study. (a) The 10-min frame reconstructed image corresponding to 15–25 min of the rest and stress studies as a fused image over the three axes (short axis, vertical and horizontal long axes). The rest study is in gray color scale and stress is in color. (b) The polar map of the estimated coronary/cardiac flow reserve (CFR) for this subject.
Kinetic parameters of K 1 and k 2 estimated from the clinical 18F-Flurpiridaz studies and used for Monte Carlo simulations.
The initial guess and bounds for parameter estimation.
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