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Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation
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10.1118/1.3673771
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    Affiliations:
    1 Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC—Universitat Politècnica de València—CIEMAT, camino de Vera s/n, 46022 Valencia, Spain
    2 Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC—Universitat Politècnica de València—CIEMAT, camino de Vera s/n, 46022 Valencia, Spain and Instituto de Física Corpuscular, Centro mixto CSIC-Univ. de Valencia, Edificio Institutos de Investigación, Paterna, E-46071 Valencia, Spain
    3 ONCOVISION, Ciudad Politécnica de la Innovación, Camino de Vera s/n, E-46022 Valencia, Spain
    4 Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC—Universitat Politècnica de València—CIEMAT, camino de Vera s/n, 46022 Valencia, Spain
    5 Unidad de Investigación Biomédica en Cáncer INCan-UNAM, Departamento de Medicina Nuclear, Instituto Nacional de Cancerología, Mexico City, Mexico and Instituto de Física, Universidad Nacional Autónoma de México, A.P. 20-364, México 01000, México
    6 Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC—Universitat Politècnica de València—CIEMAT, camino de Vera s/n, 46022 Valencia, Spain
    a) Author to whom correspondence should be addressed. Electronic mail: filsan@i3m.upv.es
    Med. Phys. 39, 643 (2012); http://dx.doi.org/10.1118/1.3673771
/content/aapm/journal/medphys/39/2/10.1118/1.3673771
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/2/10.1118/1.3673771

Figures

Image of FIG. 1.
FIG. 1.

(a) The small animal PET showing its eight modules. (b) Schematic view of PET, showing axial dimensions of the modules active surface (40 mm). The allowed module coincidences reduce geometric aperture from 111 mm to an 80 mm in diameter useful transaxial FOV. In this figure partial cross section of two modules is displayed.

Image of FIG. 2.
FIG. 2.

One of the eight modules of the small animal PET (left). Monolithic LYSO crystal. The truncated pyramid shape of the crystal can be appreciated (right).

Image of FIG. 3.
FIG. 3.

Schematic view of PET system, showing the planar source used for normalization of the LORs “connecting” modules (1,4), (1,5), (1,6), (5,2), and (5,8). The source is located in the centre of the axial and transaxial FOV. The source is conveniently rotated for normalization of the rest of module pairs.

Image of FIG. 4.
FIG. 4.

Absolute axial sensitivity profile obtained using a 30% (358–664 keV, •) and 50% (256–766 keV, Δ) energy windows (EW).

Image of FIG. 5.
FIG. 5.

Rtot,j , Rtrue,j , Rscattered,j , Rrandom,j , and RNEC,j as a function of the average activity concentration present at the different acquisitions j for mouse-like phantom.

Image of FIG. 6.
FIG. 6.

Same as Fig. 6 for rat-like phantom.

Image of FIG. 7.
FIG. 7.

Image quality NEMA phantom used in this work.

Image of FIG. 8.
FIG. 8.

Images obtained with the phantom of Fig. 7. For the image reconstruction, a 3D standard MLEM algorithm was used. The final image after 12 iterations is shown. (a) Transverse plane of uniform region; (b) coronal plane; (c) transverse single image slice averaged over the central axial 10-mm length of the rods, used for RC calculation; and (d) water- and air-filled cylindrical inserts.

Image of FIG. 9.
FIG. 9.

Mouse images acquired with the PET scanner developed by the authors. On the left, a healthy mouse heart (transaxial, sagittal, and coronal views) and on the right coronal views of a mouse brain during an epileptic episode. The arrows indicate the epileptic focus location.

Tables

Generic image for table
TABLE I.

Spatial resolution values (FWHM in mm) obtained in all three directions at two different axial positions.

Generic image for table
TABLE II.

RC and SDRC obtained with the image quality NEMA phantom.

Generic image for table
TABLE III.

Performance parameters of some recent reported small animal PET scanners.

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/content/aapm/journal/medphys/39/2/10.1118/1.3673771
2012-01-12
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/2/10.1118/1.3673771
10.1118/1.3673771
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