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MR-guided adaptive focusing of therapeutic ultrasound beams in the human head
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10.1118/1.3678988
/content/aapm/journal/medphys/39/2/10.1118/1.3678988
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/2/10.1118/1.3678988
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

MR-ARFI sequence used for the adaptive focusing of HIFU beams. Two rectangular bipolar MSG were added to a standard multislice spin-echo sequence with EPI readout. Two sonications were synchronized to the MSG periods.

Image of FIG. 2.
FIG. 2.

(a) MR-ARFI phase image without US emission, (b) with US emission, and (c) final encoded displacement given by the difference of both images.

Image of FIG. 3.
FIG. 3.

(a) Representation of the 512 element HIFU transducer. The 384 elements used are plotted as round shapes and color intensity corresponds to the virtual skull phase aberration used. (b) Standard anatomic T1 weighted MR image of the setup (sagittal view) with schematic location of the probe on the left, focus in theMR-ARFI vertical imaging plane on the right. (c) Standard anatomic T1 weighted MR image of the calf brain sample in the MR-ARFI imaging plane with the MR-ARFI rectangular slice positioning at center, saturation bands on the sides and probe focus at the cross location.

Image of FIG. 4.
FIG. 4.

Illustration of the experimental setup.

Image of FIG. 5.
FIG. 5.

Weighted image of thehuman cadaver head in the MR-ARFI imaging plane with MR-ARFI slice positioning at center, saturation bands on the sides and probe focus at the cross location.

Image of FIG. 6.
FIG. 6.

Example of encoded displacement (a), (b), (c), and (d), respectively, for emission vectors 1, 6, 7, and 8.

Image of FIG. 7.
FIG. 7.

MR-ARFI encoded displacement obtained with: (a) aberration, (b) no aberration, (c) aberration and energy-based adaptive focusing correction, and (d) lateral profiles of the slices.

Image of FIG. 8.
FIG. 8.

MR-ARFI encoded displacement obtained with: (a) no correction, (b) simulation based correction, (c) energy-based adaptive focusing correction, and (d) lateral profiles of the slices.

Image of FIG. 9.
FIG. 9.

MR-ARFI encoded displacement obtained with: (a) no correction, (b) simulation based correction alone, (c) simulation based correction plus energy-based adaptive focusing correction, and (d) lateral profiles of the slices.

Image of FIG. 10.
FIG. 10.

Estimated acoustic intensity relative to the optimal focusing intensity.

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/content/aapm/journal/medphys/39/2/10.1118/1.3678988
2012-02-06
2014-04-25
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: MR-guided adaptive focusing of therapeutic ultrasound beams in the human head
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/2/10.1118/1.3678988
10.1118/1.3678988
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