Selected axial images of transgenic mice (left column) and corresponding proton free induction decays (right column, data points shown by open circles) over the tissues indicated by the arrows for: (a) Lymph node tissue, and (b) tumor. Both lymph node and tumor FIDs can be accurately fit with a single exponential decay function (line).
Selected axial fat suppressed images of mammary glands from transgenic mice (left column top) and corresponding T2* curves (right column, data given by open circles) over the ROIs indicated by the arrow for: (a) normal mammary gland (NMG) tissue and (b) MIN lesion. H&E sections (left column bottom) are provided at 12.6× magnification. Normal mammary tissue and MIN data are fit by both single (dark line) and complex double (light line) exponential decay functions. The modulus of the complex double exponential decay function (light line) is clearly necessary to accurately model the FIDs that include a fat component.
T2* values are reported for MIN and normal mammary glands for both water and fat signals acquired with and without fat suppression. There is a significant difference between the water T2* in normal glands with and without fat suppression, with fat suppressed normal mammary glands having a longer T2*. When fat suppression is used, the calculated T2* is significantly longer for normal mammary glands than for MIN lesions.
Average T2* (ms) values for tissue without fat signal calculated using a single exponential decay fit over ROIs of muscle and lymph node tissues for both SV40Tag transgenic mice and FVB/N normal mice, and calculated average T2* (ms) values over ROIs of tumor for SV40Tag transgenic mice only.
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