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Strain-compounding technique with ultrasound Nakagami imaging for distinguishing between benign and malignant breast tumors
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10.1118/1.3700167
/content/aapm/journal/medphys/39/5/10.1118/1.3700167
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/5/10.1118/1.3700167

Figures

Image of FIG. 1.
FIG. 1.

Schematic of how the various distributions of scatterers in breast tumors of different stiffnesses can be classified by the strain-compounding Nakagami imaging method.

Image of FIG. 2.
FIG. 2.

Flowchart summarizing the strain-compounding Nakagami imaging method used in this study. The steps involved in strain-compounding B-scan imaging and strain-compounding Nakagami imaging are shown.

Image of FIG. 3.
FIG. 3.

Different types of images of a fibroadenoma: (a) reference B-scan, (b) strain-compounding B-scan, (c) reference Nakagami image, and (d) strain-compounding Nakagami image. The white dashed lines delineating the tumor contour were manually traced by the physician. Histograms for the tumor region in the reference Nakagami image (e) and the strain-compounding Nakagami image (f). The red lines indicate histograms fitted by Gaussian curves.

Image of FIG. 4.
FIG. 4.

Different types of images of an invasive ductal carcinoma: (a) reference B-scan, (b) strain-compounding B-scan, (c) reference Nakagami image, and (d) strain-compounding Nakagami image (d). The white dashed lines delineating the tumor contour were manually traced by the physician. Histograms for the tumor region in the reference Nakagami image (e) and the strain-compounding Nakagami image (f). The red lines indicate histograms fitted by Gaussian curves.

Image of FIG. 5.
FIG. 5.

Box plots showing the distributions of the m avg estimates for the reference and strain-compounding Nakagami images (a) and of the FWHM ratio estimates for benign and malignant tumors (b). Box plots indicate the median value (bisecting line), 25th to 75th percentiles (box boundaries), and the data range (whiskers). Single and double asterisks indicate p < 0.05 and p < 0.01, respectively.

Image of FIG. 6.
FIG. 6.

ROC curves when using the m avg estimates for the reference and strain-compounding Nakagami images, and the FWHM ratio estimates to classify benign and malignant breast tumors.

Image of FIG. 7.
FIG. 7.

Different types of images of a fibroadenoma associated with calcifications (yellow arrows): (a) reference B-scan, (b) strain-compounding B-scan, (c) reference Nakagami image, and (d) strain-compounding Nakagami image. The white dashed lines delineating the tumor contour were manually traced by the physician. Histograms for the tumor region in the reference Nakagami image (e) and the strain-compounding Nakagami image (f). The red lines indicate histograms fitted by Gaussian curves.

Image of FIG. 8.
FIG. 8.

Different types of images of a fibroadenoma and an invasive ductal carcinoma, both with diameters larger than 4 cm. Reference B-scan images of the fibroadenoma (a) and the invasive ductal carcinoma (b). Reference Nakagami images of the fibroadenoma (c) and the invasive ductal carcinoma (d). Strain-compounding Nakagami images of the fibroadenoma (e) and the invasive ductal carcinoma (f). The white dashed lines delineating the tumor contour were manually traced by the physician. Gaussian fitting curves (red lines) of the histograms in the reference Nakagami images (g, h) and the strain-compounding Nakagami images (i, j) for the fibroadenoma and the invasive ductal carcinoma.

Tables

Generic image for table
TABLE I.

Correlations between ultrasound findings and histology findings of 50 breast tumors.

Generic image for table
TABLE II.

Individual performances assessed by the accuracy, specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV), and A z value (mean ± standard error and 95% confidence interval) of each parameter in classifying benign and malignant breast tumors.

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/content/aapm/journal/medphys/39/5/10.1118/1.3700167
2012-04-11
2014-04-21
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Strain-compounding technique with ultrasound Nakagami imaging for distinguishing between benign and malignant breast tumors
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/5/10.1118/1.3700167
10.1118/1.3700167
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