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Decision support system for localizing prostate cancer based on multiparametric magnetic resonance imaging
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10.1118/1.4722753
/content/aapm/journal/medphys/39/7/10.1118/1.4722753
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4722753

Figures

Image of FIG. 1.
FIG. 1.

Flow chart for a DSS based on a multiparametric MRI. The cancer probability map is the final outcome of the algorithm.

Image of FIG. 2.
FIG. 2.

Top view of the patient-specific mold showing the prostate cavity (wire mesh), the slots for the knife every 6 mm, and correspondence of the locations of 5 mm histology slices to the locations of MP-MRI slices. The rectangular outlines near each slot indicate the location of optional windows that were also visible in the MRI slices shown in Figs. 3(d)–3(f) and 4(d)–4(f).

Image of FIG. 3.
FIG. 3.

Selected slices from MR images of a prostate gland in vivo (a)–(c) and ex vivo inside a mold (d)–(f) showing good correlation when tissue shrinkage was minimal.

Image of FIG. 4.
FIG. 4.

Selected slices from MR images of a prostate gland acquired in vivo (a)–(c) and ex vivo inside a mold (d)–(f) showing poor correlation when tissue shrinkage was significant.

Image of FIG. 5.
FIG. 5.

T 2-weighted image (a) and segmented region map (b) from MP-MRI images show good correspondence with histology map gold standard (c).

Image of FIG. 6.
FIG. 6.

Box and whisker plot for cancer (C) and noncancer regions (NC). Center line = median, top of box = 75th percentile, bottom of box = 25th percentile, whiskers = data within 1.5 interquartile ranges, outlier = +, shape of the notches represents statistically significant differences between two groups p < 0.0001 for all modalities.

Image of FIG. 7.
FIG. 7.

DSS performance using individual MR sequences in comparison to different combinations of multiparametric MR images.

Image of FIG. 8.
FIG. 8.

Illustration of the DSS. Multiparametric MRI images (a)–(c), resulting color coded cancer probability map (d) superimposed on T2W image with a white arrow indicating region of highest probability, and histopathology slide (e) confirming the presence of tumor (Gleason score 3 +4, dotted line) in the region with the highest probability. The anterior (A), posterior (P), left (L), and right (R) sides are labeled.

Tables

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TABLE I.

Definition terms for contingency table used in system evaluation.

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TABLE II.

Results from ex vivo validation of PSM.

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TABLE III.

Results without optimized SVM parameters.

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TABLE IV.

Results with optimized SVM parameters.

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/content/aapm/journal/medphys/39/7/10.1118/1.4722753
2012-06-11
2014-04-24
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Decision support system for localizing prostate cancer based on multiparametric magnetic resonance imaging
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4722753
10.1118/1.4722753
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