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Hyperpolarized 3He pulmonary functional magnetic resonance imaging prior to radiation therapy
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10.1118/1.4729713
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    Affiliations:
    1 Imaging Research Laboratories, Robarts Research Institute and Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    2 Department of Medical Biophysics, The University of Western Ontario and Department of Oncology, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    3 Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    4 Department of Oncology, The University of Western Ontario, London, Ontario N6A 5K8, Canada; Radiation Oncology Program, London Regional Cancer Program, London Health Sciences Centre, London, Ontario N6A 5W9, Canada; and Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    5 Imaging Research Laboratories, Robarts Research Institute; Department of Medical Biophysics, Department of Medical Imaging, Department of Oncology, The University of Western Ontario; London, Ontario N6A 5K8, Canada, and Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    a) Author to whom correspondence should be addressed. Electronic mail: lindsay.mathew@jcc.hhsc.ca; Telephone: (905) 387-9711 ext. 67010.
    Med. Phys. 39, 4284 (2012); http://dx.doi.org/10.1118/1.4729713
/content/aapm/journal/medphys/39/7/10.1118/1.4729713
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4729713

Figures

Image of FIG. 1.
FIG. 1.

(i) Static ventilation images and (ii) ADC maps with color bars indicating ADC in cm2/s are shown for six subjects; subjects (A)–(C) are classified as CLN based on ADC and VDP measurements of the contralateral lung (left lung for subjects A–C), while subjects (D)–(F) are classified as CLC based on elevated ADC and VDP values in the contralateral lung (left lung for subjects D–F).

Image of FIG. 2.
FIG. 2.

CT images as shown for (A) a 62-year-old female and (B) a 56-year-old male. (i) Pretreatment and (ii) 3.5 and 1.8 months post-treatment, respectively, with radiological evidence of radiation pneumonitis in the ipsilateral lung. Both subjects were treated with 60 Gy. Radiological RP classifications were (Aii) severe diffuse ground glass opacities and (Bii) moderate diffuse ground glass opacities.

Image of FIG. 3.
FIG. 3.

12-month survival curves are shown for CLC subjects and CLN subjects with 12-month survival rates of 2/10 and 3/5, respectively.

Tables

Generic image for table
TABLE I.

Baseline clinical demographics.

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TABLE II.

Clinical and imaging measurements by contralateral lung classification.

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TABLE III.

RILI and survival by contralateral lung classification.

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/content/aapm/journal/medphys/39/7/10.1118/1.4729713
2012-06-22
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Hyperpolarized 3He pulmonary functional magnetic resonance imaging prior to radiation therapy
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4729713
10.1118/1.4729713
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