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Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with 177Lu- and 90Y-BR96 mAbs
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10.1118/1.4730499
/content/aapm/journal/medphys/39/7/10.1118/1.4730499
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4730499

Figures

Image of FIG. 1.
FIG. 1.

Red marrow-to-blood ratio (RMBLR) increases with time for 111In-BR96-mAbs in Brown Norway rats.

Image of FIG. 2.
FIG. 2.

The principle of the nadir curve and the particular parameters defined in this study (drop, recovery, ABC, and severity) for the studied animal (dashed line) and control group (dotted line).

Image of FIG. 3.
FIG. 3.

The parameters recovery (top left), severity (top right), ABC (bottom left), and drop (bottom right) for platelets plotted against bone marrow absorbed dose for 177Lu (◊) and 90Y (x) with best fit (line and dashed line, respectively).

Image of FIG. 4.
FIG. 4.

In the figure is displayed the parameters recovery (top left), severity (top right), ABC (bottom left) and drop (bottom right) for white blood cells plotted against bone marrow absorbed dose for 177Lu (◊) and 90Y (x) with best fit (line and dashed line, respectively).

Image of FIG. 5.
FIG. 5.

The parameters recovery (top left), severity (top right), ABC (bottom left), and drop (bottom right) for variation in body weight plotted against total body absorbed dose for 177Lu (◊) and 90Y (x) with coefficient of determination and best fit (black line).

Tables

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TABLE I.

Organ weights for Brown Norway rats and the Roby (Ref. 9) phantoms.

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TABLE II.

Residence times for 90Y- and 177Lu-labeled BR96 mAbs.

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TABLE III.

S factors for Brown Norway rat (225 g) for 90Y [mGyMBq−1h].

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TABLE IV.

S factors for Brown Norway rat (225 g) for 177Lu [mGyMBq−1h−1].

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TABLE V.

Absorbed doses [Gy] at maximal tolerable activity for the Brown Norway phantom and the original Roby phantom at different phantom weights.

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/content/aapm/journal/medphys/39/7/10.1118/1.4730499
2012-06-28
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with 177Lu- and 90Y-BR96 mAbs
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/7/10.1118/1.4730499
10.1118/1.4730499
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