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Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT
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10.1118/1.4736808
    + View Affiliations - Hide Affiliations
    Affiliations:
    1 Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242
    2 Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242
    3 Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242 and Department of Radiology, The University of Iowa, Iowa City, Iowa 52242
    4 Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242
    5 Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242 and Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa 52242
    6 Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242 and Department of Radiology, The University of Iowa, Iowa City, Iowa 52242
    7 Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa 52242
    a) Dr. Ding is currently with the Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908.
    b) Dr. Reinhardt and Dr. Hoffman are founders and shareholder of VIDA Diagnostics, Inc.
    c) Author to whom correspondence should be addressed. Electronic mail: joe-reinhardt@uiowa.edu; Telephone: (319) 335-5634; FAX: (319) 335-5631.
    Med. Phys. 39, 5084 (2012); http://dx.doi.org/10.1118/1.4736808
/content/aapm/journal/medphys/39/8/10.1118/1.4736808
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/8/10.1118/1.4736808

Figures

Image of FIG. 1.
FIG. 1.

Figure shows the two types of images, an image pair of full lung volumetric phases EE and EI from a 4DCT scan and a Xe-CT scan acquired at the end of expiration over 45 respiratory cycles (EE0 to EE44), which are analyzed during the processing. Transformation T1 registers EI to EE data and can be used to assess local lung function via calculations of three ventilation measures: SAJ, SACJ, and SAI. The 45 distinctive partial lung volumetric Xe-CT scans EE0 to EE44 are used to calculate Xe-CT based measure of sV. Transformation T2 maps the sV data into the coordinate system of the EE image (end expiration phase of the 4DCT scan) to allow direct comparison with the 4DCT and registration based measures of ventilation. Both EE and EE0 are at volumes near end inspiration. (Shaded boxes indicate CT image data; white boxes indicated derived or calculated data; thick arrows indicate image registration transformations being calculated; thin solid lines indicate other operations.)

Image of FIG. 2.
FIG. 2.

Example of a region under deformation h(x) from template image to target image. V 1 and V 2 are tissue volumes in the regions. and are air volumes in the regions. Region volumes and .

Image of FIG. 3.
FIG. 3.

Example of a given region under deformation h(x) from template image to target image, with the assumption of no tissue volume (V 1 = V 2 = 0). and are air volumes.

Image of FIG. 4.
FIG. 4.

Example of a given voxel under deformation h(x) from template image to target image, with the assumption of no tissue volume change. Notice the tissue volume V 1 = V 2 under this assumption. and are air volumes.

Image of FIG. 5.
FIG. 5.

3D view of the landmarks in (a) EE with EE0 and (b) EI. The dark region below the carina in (a) is the EE0 and the spheres are the automatically defined landmarks.

Image of FIG. 6.
FIG. 6.

Landmarks distances of the registration pair EI to EE for all four animals. Boxplot lower extreme is first quartile, boxplot upper extreme is third quartile. Median is shown with solid horizontal line. Whiskers show either the minimum (maximum) value or extend 1.5 times the first to third quartile range beyond the lower (upper) extreme of the box, whichever is smaller (larger). Outliers are marked with circles.

Image of FIG. 7.
FIG. 7.

Visualization of the result of the transformation that maps the Xe-CT estimated ventilation sV to the EE coordinate system: (a) EE, (b) EE0, (c) deformed EE0 after registration, (d) intensity difference between EE and EE0 before registration, (e) intensity difference between EE and EE0 after registration.

Image of FIG. 8.
FIG. 8.

Comparison of the regional ventilation measures for animal D. (a) EE with color coded cubes showing the sample region. (b)–(e) Color map of the sV, SAJ, SACJ, and SAI. Note that the color scales are different for (b)–(e), and are set based on the range of values from the appropriate plot in Fig. 9. The results were similar for the other three animals.

Image of FIG. 9.
FIG. 9.

Small cube ROIs with size 20 mm × 20 mm × 20 mm results for registration estimated ventilation measures compared to the Xe-CT estimated ventilation sV in scatter plot with linear regression in four animals. The first column is the SAJ vs sV. The second column is the SACJ vs sV. The third column is the SAI vs sV.

Image of FIG. 10.
FIG. 10.

Large slab ROIs with size 150 mm × 8 mm × 40 mm results for registration estimated ventilation measures compared to the Xe-CT estimated ventilation sV in scatter plot with linear regression in four animals. The first column is the SAJ vs sV. The second column is the SACJ vs sV. The third column is the SAI vs sV.

Image of FIG. 11.
FIG. 11.

Linear regression analysis between DSA and DT. (a)–(d) DSA (the absolute difference of the value between the SACJ and SAI) compared to DT (the absolute difference of the tissue volume) in animals A, B, C, and D.

Tables

Generic image for table
TABLE I.

Comparison of ventilation measures between SACJ and SAI in small cube ROIs with size 20 mm × 20 mm × 20 mm.

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TABLE II.

Comparison of ventilation measures between SAJ and SAI in small cube ROIs with size 20 mm × 20 mm × 20 mm.

Generic image for table
TABLE III.

Comparison of ventilation measures between SACJ and SAJ in small cube ROIs with size 20 mm × 20 mm × 20 mm.

Generic image for table
TABLE IV.

Comparison of ventilation measures between SACJ and SAI in large slab ROIs with size 150 mm × 8 mm × 40 mm.

Generic image for table
TABLE V.

Comparison of ventilation measures between SAJ and SAI in large slab ROIs with size 150 mm × 8 mm × 40 mm.

Generic image for table
TABLE VI.

Comparison of ventilation measures between SACJ and SAJ in large slab ROIs with size 150 mm × 8 mm × 40 mm.

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/content/aapm/journal/medphys/39/8/10.1118/1.4736808
2012-07-27
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/8/10.1118/1.4736808
10.1118/1.4736808
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