To compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners.Methods:
The study was performed in 34 healthy Asian volunteers using two 1.5T (GE and Siemens) and two 3T (GE and Philips) MR scanners. The BV, FV, and PD were measured on nonfat-suppressed T1-weighted images using a comprehensive computer algorithm-based segmentation method. The scanner-to-scanner measurement difference, and the coefficient of variation (CV) among the four scanners were calculated. The measurement variation between two density morphological patterns presenting as the central type and the intermingled type was separately analyzed and compared.Results:
All four scanners provided satisfactory image quality allowing for successful completion of the segmentation processes. The measured parameters between each pair of MR scanners were highly correlated, with R2 ≥ 0.95 for BV, R2 ≥ 0.99 for FV, and R2 ≥ 0.97 for PD in all comparisons. The mean percent differences between each pair of scanners were 5.9%–7.8% for BV, 5.3%–6.5% for FV, 4.3%–7.3% for PD; with the overall CV of 5.8% for BV, 4.8% for FV, and 4.9% for PD. The variation of FV was smaller in the central type than in the intermingled type (p = 0.04).Conclusions:
The results showed that the variation of FV and PD measured from four different MR scanners is around 5%, suggesting the parameters measured using different scanners can be used for a combined analysis in a multicenter study.
This work was supported in part by National Institutes of Health (NIH)/National Cancer Institute (NCI) Grant Nos. R01 CA127927 and R03 CA136071.
II. MATERIALS AND METHODS
II.B. MR imaging studies
II.C. Breast and fibroglandular tissue segmentation
II.D. Classification of morphological pattern into the central type and the intermingled type
II.E. Statistical methods
III.A. Measurement variation between each pair of four MR scanners
III.B. Coefficient of variation in all breasts and the central and intermingled morphological types
III.C. Coefficient of variation in four quartile groups based on FV values
- Image scanners
- Medical imaging
- Medical image segmentation
- Magnetic resonance imaging
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