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Consistency of breast density measured from the same women in four different MR scanners
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10.1118/1.4736824
/content/aapm/journal/medphys/39/8/10.1118/1.4736824
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/8/10.1118/1.4736824

Figures

Image of FIG. 1.
FIG. 1.

A 55-year-old woman with the intermingled morphological type. (Left column) Original images; (Right column) segmented images; images from top to bottom in each column were acquired from GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The breast volume (BV) was 785, 900, 840, and 853 cm3; the fibroglandular tissue volume (FV) was 57.0, 63.1, 62.5, and 61.8 cm3; and the percent density (PD) was 7.3%, 7.0%, 7.4%, and 7.3% for GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The overall coefficient of variation measured from four scanners was 5.6% for BV, 4.6% for FV, and 4.6% for PD.

Image of FIG. 2.
FIG. 2.

A 25-year-old woman with the central morphological type. (Left column) Original images; (Right column) segmented images; images from top to bottom in each column were acquired from GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The breast volume (BV) was 328, 362, 390, and 366 cm3; the fibroglandular tissue volume (FV) was 148.8, 160.2, 160.5, and 158.5 cm3; and the percent density (PD) was 45.4%, 44.2%, 41.1%, and 43.3% for GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The overall coefficient of variation measured from four scanners was 7.1% for BV, 3.5% for FV, and 4.2% for PD.

Image of FIG. 3.
FIG. 3.

A 28-year-old woman with the central morphological type. (Left column) Original images; (Right column) segmented images; images from top to bottom in each column were acquired from GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The breast volume (BV) was 261, 203, 275, and 261 cm3; the fibroglandular tissue volume (FV) was 65.5, 50.8, 66.5, and 69.7 cm3; and the percent density (PD) was 25.1%, 25.0%, 24.1%, and 26.7% for GE 1.5T, GE 3.0T, Philips 3.0T, and Siemens 1.5T, respectively. The overall coefficient of variation measured from four scanners was 12.8% for BV, 13.3% for FV, and 4.3% for PD. The measurement CV for BV and FV of this breast is the highest among all central type cases. The high CV is caused by the much smaller BV and FV measured using the GE 3.0T scanner; however, because both the BV and the FV are smaller, the calculated PD is similar to the PD measured by the other three scanners.

Image of FIG. 4.
FIG. 4.

The correlation of breast volume (BV) measured using each pair of different MR scanners. The BV of several subjects measured by the Siemens 1.5T scanner is smaller compared to others, so in general the paired comparison with Siemens 1.5T has a lower R2 (0.95, 0.96, and 0.97) compared to the values in the other three comparisons (0.98, 0.98, and 0.99).

Image of FIG. 5.
FIG. 5.

The correlation of fibroglandular tissue volume (FV) measured using each pair of different MR scanners. The measured FV is highly correlated, with R2 = 0.99 in all six comparisons.

Image of FIG. 6.
FIG. 6.

The correlation of percent density (PD) measured using each pair of different MR scanners. R2 ranged from 0.97 to 0.99.

Image of FIG. 7.
FIG. 7.

The level of uncertainty in each pair of comparison for PD. The region between the two thin dashed lines contains 95% of the data. A high correlation was noted between any pair of 1.5T GE, 3.0T GE, and 3.0T Philips (all norm residuals numbers <13). When Siemens was compared with any one of the three other MR scanners, the level of uncertainty becomes bigger (norm residuals > 16).

Tables

Generic image for table
TABLE I.

Mean value of BV, FV, and PD from 68 breasts measured by four MR scanners.

Generic image for table
TABLE II.

Measurement difference between each pair of two different MR scanners.

Generic image for table
TABLE III.

The CV from four scanners in all breasts, and the central and intermingled types.

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/content/aapm/journal/medphys/39/8/10.1118/1.4736824
2012-07-20
2014-04-17
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Consistency of breast density measured from the same women in four different MR scanners
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/39/8/10.1118/1.4736824
10.1118/1.4736824
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