Intensity modulated neutron radiotherapy optimization by photon proxy
A schematic of the treatment planning process. Segment shapes defined by MLC leaf positions determined for a 4 MV proxy linear accelerator are translated into individual beam aperatures readable by our in-house treatment planning system. Dose calculated in the in-house treatment planning system is exported to Eclipse for evaluation.
A dose plan comparison: (a) a standard 3D plan created in VRSPlan, and (b) a plan created using the inverse optimization algorithm in Varian's Eclipse with a 4 MV proxy, recalculated in VRSPlan for our neutron therapy machine.
DVH comparison for mock rectum, bladder, and prostate-PTV using a 3D conformal plan and an IMNRT plan created using the presented methodology. The rectal DVH for the IMNRT plan improves upon that achieved using the 3D conformal technique while maintaining target coverage.
DVH comparison for rectum and prostate-PTV as calculated in Eclipse for a 4 MV proxy beam and in VRSPlan for the actual neutron beam model using the same segment shapes.
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