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Survival of tumor and normal cells upon targeting with electron-emitting radionuclides
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10.1118/1.4769409
/content/aapm/journal/medphys/40/1/10.1118/1.4769409
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/1/10.1118/1.4769409
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Figures

Image of FIG. 1.
FIG. 1.

Effect of electron energy and fraction of cells labeled on the shape of the survival curve for the labeled cell population when monoenergetic electron emitters are uniformly distributed among the labeled cells: (Top) 10 keV. (Middle) 100 keV. (Bottom) 1000 keV. The surviving fraction of labeled cells is plotted as a function of mean absorbed dose to the labeled cell nuclei when different fractions of the entire cell population are labeled: 100%, 50%, 10%, and 1%. The lower and upper dashed lines represent exponential survival curves with D37 = D37,self = 1.2 Gy and D37 = D37,cross = 4.0 Gy, respectively. At very low energies (10 keV), where the cross-dose to the nucleus is negligible, the curve expectantly follows that for D37 = D37,self = 1.2 Gy. Similarly, at high energies (1000 keV), where the cross-dose dominates, the curve expectantly follows that for D37 = D37,cross = 4.0 Gy. A complete set of curves including 10, 30, 100, 300, and 1000 keV is provided in Fig. 1 of the supplementary material (B) (Ref. 50 ). For the sake of comparison, the data for 100% labeling are reproduced from Rajon et al. (Ref. 32 ).

Image of FIG. 2.
FIG. 2.

(a). Effect of energy and fraction of cells labeled on the shape of the survival curve for the unlabeled cell population when monoenergetic electron emitters are uniformly distributed among the labeled cells. (Top) 30 keV. (Bottom) 100 keV. The surviving fraction of unlabeled cells is plotted as a function of mean absorbed dose to the unlabeled cell nuclei. The survival curves are shown for three different labeled fractions: 50%, 10%, and 1% (no unlabeled cells at 100%). The lower and upper dashed lines represent exponential survival curves with D37 = D37,self = 1.2 Gy and D37 = D37,cross = 4.0 Gy, respectively. A complete set of curves including 10, 30, 100, 300, and 1000 keV is provided in Fig. 2 of the supplementary material (B) (Ref. 50 ). (b) Frequency distribution of self- (Left) and cross-doses (Right) received by cells when a 30 keV monoenergetic electron emitter is distributed uniformly among 100%, 50%, 10%, or 1% of the cells. The Monte-Carlo simulation that generated this distribution transported 3 × 108 histories for a mean total dose of 1.17 Gy per cell.

Image of FIG. 3.
FIG. 3.

Effect of fraction of cells labeled on the shape of the survival curve for the mixed cell population (labeled + unlabeled) when a 100-keV monoenergetic electron emitter is uniformly distributed among the labeled cells. The surviving fraction of mixed cells is plotted as a function of mean absorbed dose to all cell nuclei. The survival curves are shown for four different labeled fractions: 100%, 50%, 10%, and 1%. The lower and upper dashed lines represent exponential survival curves with D37 = D37,self = 1.2 Gy and D37 = D37,cross = 4.0 Gy, respectively. A complete set of curves for all combinations of energy and fraction of cells labeled is provided in Fig. 3 of the supplementary material (B) (Ref. 50 ). For the sake of comparison, the data for 100% labeling are reproduced from Rajon et al. (Ref. 32 ).

Image of FIG. 4.
FIG. 4.

Combined effect of labeled fraction and of activity distribution on the cell survival-response of labeled cells when a 1000-keV monoenergetic electron emitter is lognormally distributed among the labeled cells. From left to right, the percentage of cells labeled is 100%, 50%, 10%, and 1%. The surviving fraction of mixed cells is plotted as a function of mean absorbed dose to all cell nuclei. The activity distribution is uniform (σ → 0) or lognormal with shape parameters of σ = 0.6, 1.0, and 2.0. The dashed lower and upper lines represent exponential survival curves with D37 = D37,self = 1.2 Gy and D37 = D37,cross = 4.0 Gy, respectively. A complete set of curves for all combinations of energy and fraction of cells labeled is provided in Fig. 4 of the supplementary material (B) (Ref. 50 ). For the sake of comparison, the data for 100% labeling are reproduced from Rajon et al. (Ref. 32 ).

Image of FIG. 5.
FIG. 5.

Combined effect of labeled fraction and of activity distribution on the cell survival-response of unlabeled cells when 10% of the cells are labeled with 30-keV (Top) and 100-keV (Bottom) monoenergetic electron emitters. The surviving fraction of mixed cells is plotted as a function of mean absorbed dose to all cell nuclei. The activity distribution is uniform (σ → 0) or lognormal with shape parameters of σ = 0.6, 1.0, and 2.0. The dashed lower and upper lines represent exponential survival curves with D37 = D37,self = 1.2 Gy and D37 = D37,cross = 4.0 Gy, respectively. A complete set of curves for all combinations of energy and fraction of cells labeled is provided in Fig. 5 of the supplementary material (B) (Ref. 50 ).

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/content/aapm/journal/medphys/40/1/10.1118/1.4769409
2012-12-26
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Survival of tumor and normal cells upon targeting with electron-emitting radionuclides
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/1/10.1118/1.4769409
10.1118/1.4769409
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