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Impact of variable RBE on proton fractionation
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10.1118/1.4769417
/content/aapm/journal/medphys/40/1/10.1118/1.4769417
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/1/10.1118/1.4769417

Figures

Image of FIG. 1.
FIG. 1.

Variation of the RBE with proton dose-per-fraction for tissues with various fractionation sensitivities.

Image of FIG. 2.
FIG. 2.

Proton doses per fraction and the number of fractions for isoeffective treatments calculated to give an EQD1.1 = 70 Gy for α/β = 3 Gy [Eq. (7) ].

Image of FIG. 3.
FIG. 3.

Equivalent photon doses in 2 Gy per fraction calculated for late reacting tissues (α/β = 3 Gy) and LET = 3 eV/nm for the treatments in Fig. 2 using Eqs. (5) (solid line) or (7) (dashed line).

Image of FIG. 4.
FIG. 4.

Equivalent photon doses in 2 Gy per fraction calculated for rapidly growing tumors (α/β = 10 Gy) and LET = 3 eV/nm for the treatments in Fig. 2 using Eqs. (5) (solid line) or (7) (dashed line).

Image of FIG. 5.
FIG. 5.

Equivalent photon doses in 2 Gy per fraction calculated for slowly growing tumors (α/β = 1.5 Gy) and LET = 3 eV/nm for the treatments in Fig. 2 using Eqs. (5) (solid line) or (7) (dashed line).

Image of FIG. 6.
FIG. 6.

Relative deviation of predictions from a variable DMF α versus the generic RBE = 1.1 [Eq. (8) ] for combinations of doses, LET, and fractionation sensitivities (α/β) that may be encountered outside the target.

Tables

Generic image for table
TABLE I.

Predictions for biochemical tumor control probabilities (bTCP) for proton treatments for prostate cancer.

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/content/aapm/journal/medphys/40/1/10.1118/1.4769417
2012-12-13
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Impact of variable RBE on proton fractionation
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/1/10.1118/1.4769417
10.1118/1.4769417
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