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1. F. Habibollahi, H. M. Mayles, W. P. Mayles, P. J. Winter, D. Tong, I. S. Fentiman, M. A. Chaudary, and J. L. Hayward, “Assessment of skin dose and its relation to cosmesis in the conservative treatment of early breast cancer,” Int. J. Radiat. Oncol., Biol., Phys. 14, 291296 (1988).
2. S. J. Thomas and A. C. Hoole, “The effect of optimization on surface dose in intensity modulated radiotherapy (IMRT),” Phys. Med. Biol. 49, 49194928 (2004).
3. A. C. Shiau, P. L. Lai, J. A. Liang, P. W. Shueng, W. L. Chen, and W. P. Kuan, “Dosimetric verification of surface and superficial doses for head and neck IMRT with different PTV shrinkage margins,” Med. Phys. 38, 14351443 (2011).
4. A. C. Shiau, M. C. Chiu, T. H. Chen, J. F. Chiou, P. W. Shueng, S. W. Chen, W. L. Chen, and W. P. Kuan, “Surface and superficial dose dosimetric verification for postmastectomy radiotherapy,” Med. Dosim. 37, 417424 (2012).
5. L. E. Court, R. Tishler, H. Xiang, A. M. Allen, M. Makrigiorgos, and L. Chin, “Experimental evaluation of the accuracy of skin dose calculation for a commercial treatment planning system,” J. Appl. Clin. Med. Phys. 9(1), 2935 (2008).
6. S. Mutic and D. A. Low, “Superficial doses from serial tomotherapy delivery,” Med. Phys. 27, 163165 (2000).
7. Z. Y. Qi, X. W. Deng, S. M. Huang, L. Zhang, Z. C. He, X. A. Li, I. Kwan, M. Lerch, D. Cutajar, P. Metcalfe, and A. Rosenfeld, “In vivo verification of superficial dose for head and neck treatments using intensity-modulated techniques,” Med. Phys. 36, 5970 (2009).
8. H. Bilge, N. Ozbek, M. Okutan, A. Cakir, and H. Acar, “Surface dose and build-up region measurements with wedge filters for 6 and 18 MV photon beams,” Jpn. J. Radiol. 28, 110116 (2010).
9. G. Yadav, R. S. Yadav, and A. Kumar, “Skin dose estimation for various beam modifiers and source-to-surface distances for 6MV photons,” J. Med. Phys. 34, 8792 (2009).
10. N. Dogan and G. P. Glasgow, “Surface and build-up region dosimetry for obliquely incident intensity modulated radiotherapy 6 MV x rays,” Med. Phys. 30, 30913096 (2003).
11. B. J. Gerbi, A. S. Meigooni, and F. M. Khan, “Dose buildup for obliquely incident photon beams,” Med. Phys. 14, 393399 (1987).
12. M. J. Butson, M. D. Perez, J. N. Mathur, and P. E. Metcalfe, “6MV x-ray dose in the build up region: Empirical model and the incident angle effect,” Australas. Phys. Eng. Sci. Med. 19(2), 7482 (1996).
13. M. J. Butson, T. Cheung, and P. K. Yu, “Variations in 6MV x-ray radiotherapy build-up dose with treatment distance,” Australas. Phys. Eng. Sci. Med. 26(2), 8890 (2003).
14. H. Chung, H. Jin, J. F. Dempsey, C. Liu, J. Palta, T. S. Suh, and S. Kim, “Evaluation of surface and build-up region dose for intensity-modulated radiation therapy in head and neck cancer,” Med. Phys. 32, 26822689 (2005).
15. K. Y. Quach, J. Morales, M. J. Butson, A. B. Rosenfeld, and P. E. Metcalfe, “Measurement of radiotherapy x-ray skin dose on a chest wall phantom,” Med. Phys. 27, 16761680 (2000).
16. S. Devic, J. Seuntjens, W. Abdel-Rahman, M. Evans, M. Olivares, E. B. Podgorsak, T. Vuong, and C. G. Soares, “Accurate skin dose measurements using radiochromic film in clinical applications,” Med. Phys. 33, 11161124 (2006).
17. M. Nakano, R. F. Hill, M. Whitaker, J. H. Kim, Z. Kuncic, “A study of surface dosimetry for breast cancer radiotherapy treatments using Gafchromic EBT2 film,” J. Appl. Clin. Med. Phys. 13(3), 8397 (2012).
18. P. L. Roberson, J. M. Moran, and R. Kulasekere, “Radiographic film dosimetry for IMRT fields in the nearsurface buildup region,” J. Appl. Clin. Med. Phys. 9(4), 8797 (2008).
19. M. J. Butson, T. Cheung, P. K. Yu, and M. Currie, “Surface dose extrapolation measurements with radiographic film,” Phys. Med. Biol. 49, N197N201 (2004).
20. S. T. Chiu-Tsao and M. F. Chan, “Photon beam dosimetry in the superficial buildup region using radiochromic EBT film stack,” Med. Phys. 36, 20742083 (2009).
21. T. Kron and P. Ostwald, “Skin exit dose in megavoltage x-ray beams determined by means of a plane parallel ionization chamber (Attix chamber),” Med. Phys. 22, 577578 (1995).
22. H. F. Xiang, J. S. Song, D. W. H. Chin, R. A. Cormack, R. B. Tishler, G. M. Makrigiorgos, L. E. Court, and L. M. Chin, “Build-up and surface dose measurements on phantoms using micro-MOSFET in 6 and 10 MV x-ray beams and comparisons with Monte Carlo calculations,” Med. Phys. 34, 12661273 (2007).
23. D. J. Gladstone and L. M. Chin, “Real-time, in vivo measurement of radiation dose during radioimmunotherapy in mice using a miniature MOSFET dosimeter probe,” Radiat. Res. 141, 330335 (1995).
24. D. J. Gladstone, X. Q. Lu, J. L. Humm, H. F. Bowman, and L. M. Chin, “A miniature MOSFET radiation dosimeter probe,” Med. Phys. 21, 17211728 (1994).
25. T. Kron, M. Butson, F. Hunt, and J. Denham, “TLD extrapolation for skin dose determination in vivo,” Radiother. Oncol. 41, 119123 (1996).
26. T. Kron, A. Elliot, T. Wong, G. Showell, B. Clubb, and P. Metcalfe, “X-ray surface dose measurements using TLD extrapolation,” Med. Phys. 20, 703711 (1993).
27. J. P. Lin, T. C. Chu, S. Y. Lin, and M. T. Liu, “Skin dose measurement by using ultra-thin TLDs,” Appl. Radiat. Isot. 55, 383391 (2001).
28. P. A. Cherenkov, “The spectrum of visible radiation produced by fast electrons,” Comptes Rendus De L Academie Des Sciences De L Urss 20, 651655 (1938).
29. J. V. Jelley, “Cerenkov radiation and its applications,” Br. J. Appl. Phys. 6, 227232 (1955).
30. J. Axelsson, S. C. Davis, D. J. Gladstone, and B. W. Pogue, “Cerenkov emission induced by external beam radiation stimulates molecular fluorescence,” Med. Phys. 38, 41274132 (2011).
31. R. Zhang, A. Glaser, T. V. Esipova, S. C. Kanick, S. C. Davis, S. Vinogradov, D. Gladstone, and B. W. Pogue, “Cerenkov radiation emission and excited luminescence (CREL) sensitivity during external beam radiation therapy: Monte Carlo and tissue oxygenation phantom studies,” Biomed. Opt. Express 3, 23812394 (2012).
32. R. Zhang, S. C. Davis, J. Demers, A. Glaser, D. Gladstone, S. Vinogradov, and B. W. Pogue, “Oxygen tomography by Cerenkov-excited phosphorescence during external beam irradiation,” J. Biomed. Opt. 18(5), 50503 (2013).
33. J. Axelsson, A. K. Glaser, D. J. Gladstone, and B. W. Pogue, “Quantitative Cherenkov emission spectroscopy for tissue oxygenation assessment,” Opt. Express 20, 51335142 (2012).
34. A. K. Glaser, S. C. Davis, D. M. McClatchy, R. X. Zhang, B. W. Pogue, and D. J. Gladstone, “Projection imaging of photon beams by the Cerenkov effect,” Med. Phys. 40, 012101 (14pp.) (2013).
35. A. Glaser, W. Voigt, S. C. Davis, R. Zhang, D. Gladstone, and B. W. Pogue, “Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams,” Opt. Lett. 38, 634636 (2013).
36. A. Glaser, S. C. Davis, W. Voigt, R. Zhang, B. W. Pogue, and D. Gladstone, “Projection imaging of photon beams using Čerenkov-excited fluorescence,” Physics in Medicine and Biology 58(3), 601619 (2013).
38. A. K. Glaser, R. Zhang, S. C. Davis, D. J. Gladstone, and B. W. Pogue, “Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms,” Opt. Lett. 37, 11931195 (2012).
39. P. Arce, P. R. Mendes, and J. I. Lagares, “GAMOS: A Geant4-based easy and flexible framework for nuclear medicine applications,” Nuclear Science Symposium Conference Record (IEEE 2008), pp. 31623168.
40. A. K. Glaser, S. C. Kanick, R. Zhang, P. Arce, and B. W. Pogue, “A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media,” Biomed. Opt. Express 4, 741759 (2013).
41.See for phase-space database for external beam radiotherapy.
42. B. K. Gunturk, “Fast bilateral filter with arbitrary range and domain kernels,” IEEE Trans. Image Process. 20, 26902696 (2011).
43. I. V. Meglinski and S. J. Matcher, “Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions,” Physiol. Meas. 23, 741753 (2002).
44. R. Zhang, C. J. Fox, A. K. Glaser, D. J. Gladstone, and B. W. Pogue, “Superficial dosimetry imaging of Cerenkov emission in electron beam radiotherapy of phantoms,” Phys. Med. Biol. 58, 54775493 (2013).
45. L. Archambault, T. M. Briere, and S. Beddar, “Transient noise characterization and filtration in CCD cameras exposed to stray radiation from a medical linear accelerator,” Med. Phys. 35, 43424351 (2008).
46. K. Vishwanath, K. Chang, D. Klein, Y. F. Deng, V. Chang, J. E. Phelps, and N. Ramanujam, “Portable, fiber-based, diffuse reflection spectroscopy (DRS) systems for estimating tissue optical properties,” Appl. Spectrosc. 65, 206215 (2011).
47. J. Geng, “Structured-light 3D surface imaging: A tutorial,” Adv. Opt. Photon. 3, 128160 (2011).

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Čerenkov radiation emission occurs in all tissue, when charged particles (either primary or secondary) travel at velocity above the threshold for the Čerenkov effect (about 220 KeV in tissue for electrons). This study presents the first examination of optical Čerenkov emission as a surrogate for the absorbed superficial dose for MV x-ray beams.

In this study, Monte Carlo simulations of flat and curved surfaces were studied to analyze the energy spectra of charged particles produced in different regions near the surfaces when irradiated by MV x-ray beams. Čerenkov emission intensity and radiation dose were directly simulated in voxelized flat and cylindrical phantoms. The sampling region of superficial dosimetry based on Čerenkov radiation was simulated in layered skin models. Angular distributions of optical emission from the surfaces were investigated. Tissue mimicking phantoms with flat and curved surfaces were imaged with a time domain gating system. The beam field sizes (50 × 50–200 × 200 mm2), incident angles (0°–70°) and imaging regions were all varied.

The entrance or exit region of the tissue has nearly homogeneous energy spectra across the beam, such that their Čerenkov emission is proportional to dose. Directly simulated local intensity of Čerenkov and radiation dose in voxelized flat and cylindrical phantoms further validate that this signal is proportional to radiation dose with absolute average discrepancy within 2%, and the largest within 5% typically at the beam edges. The effective sampling depth could be tuned from near 0 up to 6 mm by spectral filtering. The angular profiles near the theoretical Lambertian emission distribution for a perfect diffusive medium, suggesting that angular correction of Čerenkov images may not be required even for curved surface. The acquisition speed and signal to noise ratio of the time domain gating system were investigated for different acquisition procedures, and the results show there is good potential for real-time superficial dose monitoring. Dose imaging under normal ambient room lighting was validated, using gated detection and a breast phantom.

This study indicates that Čerenkov emission imaging might provide a valuable way to superficial dosimetry imaging in real time for external beam radiotherapy with megavoltage x-ray beams.


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