1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation
Rent:
Rent this article for
USD
10.1118/1.4823787
/content/aapm/journal/medphys/40/11/10.1118/1.4823787
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/11/10.1118/1.4823787

Figures

Image of FIG. 1.
FIG. 1.

Schematic geometry of a cell used in MCNP simulation. The cell contains 2.01 × 105 AuNPs in the extracellular space (a) and (e), on the cell surface (b) and (f), in the cytoplasm (c) and (g), or in the nucleus (d) and (h), respectively, and is exposed to x-rays. (e)–(h) are 33 times magnification of (a)–(d), respectively, to highlight the arrangement of gold nanospheres (circles in the center of hexagonals).

Image of FIG. 2.
FIG. 2.

Schematic model of a single cell (a) and (d) at the center of a 0.24 × 0.24 × 0.24 cm3 cube of tissue, a monolayer of cells in one well of a 24-well plate (b) and (e), and a cluster of cells [(c) and (f); 0.24 × 0.24 × 0.24 cm3 cube)]. (d), (e), and (f) showed the xz slices of (a), (b), and (c), respectively, while (g) illustrates the xy slice of (b) and (c) through the monolayer of cells.

Image of FIG. 3.
FIG. 3.

Plots of NDEF (a)–(c), (g)–(i) and CDEF (d)–(f) vs x-ray photon energy for 2.01 × 105 AuNPs (30 nm) per cell deposited in a single cell (a) and (d), a monolayer of cells (b) and (e), or a cluster of cells (c) and (f). (a)–(f) show the effects of AuNP location (in the EC, on the CS, in the Cy, or in the N). (g)–(i) demonstrate the influence of cell model (cluster, monolayer, or single cell). Error bars indicate the standard deviation.

Image of FIG. 4.
FIG. 4.

Linear dependence of the NDEF on the number of AuNPs per cell for 40 keV, 90 keV, and 100 kVp x-rays. AuNPs(30 nm) are present in the cytoplasm of a cluster of cells. Error bars represent the standard deviation.

Tables

Generic image for table
TABLE I.

The concentration of AuNPs (mg Au/g tissue) required to double the prescribed x-ray dose to the cell nucleus. a

Generic image for table
TABLE II.

The concentration of AuNPs (mg Au/g tissue) required to double the prescribed x-ray (40 keV) dose to the cell nucleus. a

Generic image for table
TABLE III.

The number of 30 nm AuNPs in each cell compartment determined by cell fractionation. a

Generic image for table
TABLE IV.

Comparison of calculated NDEFs and CDEFs with experimentally derived DEFs. a

Loading

Article metrics loading...

/content/aapm/journal/medphys/40/11/10.1118/1.4823787
2013-10-16
2014-04-20
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/11/10.1118/1.4823787
10.1118/1.4823787
SEARCH_EXPAND_ITEM