1887
banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Quantitative Monte Carlo-based holmium-166 SPECT reconstruction
Rent:
Rent this article for
USD
10.1118/1.4823788
/content/aapm/journal/medphys/40/11/10.1118/1.4823788
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/11/10.1118/1.4823788

Figures

Image of FIG. 1.
FIG. 1.

A schematic overview of the subsequent steps involved in simulation of a 2D projection image at a specific camera angle from a 3D source distribution with UMCS. E and represent and , respectively.

Image of FIG. 2.
FIG. 2.

Profiles through the measured and simulated projection images of a line source centered in 40 × 40 × 2 cm3 scatter material (a) and in 40 × 40 × 20 cm3 scatter material (b). Measured, MCNPX-simulated and UMCS-simulated LSFs in (a) and (b) were normalized to the maximum intensity of the respective LSF in (a). MCNPX-simulated photopeak gamma (PP), high energy gamma (HE) and bremsstrahlung photon (BS) contributions were shown in addition to the total MCNPX-simulated LSF.

Image of FIG. 3.
FIG. 3.

Image contrast (Q) and the residual count error in the lung insert (Δ ) plotted as a function of image noise (CV) for SPECT-DSW (a), SPECT-ppMC+DSW (b), and SPECT-fMC (c) with varying numbers of iterations. The number of iterations chosen as “optimal” for activity quantification is illustrated by the vertical dashed line.

Image of FIG. 4.
FIG. 4.

The left column shows the center slices through the SPECT-DSW (top), SPECT-ppMC+DSW (middle), and SPECT-fMC (bottom) reconstructed images, overlaid with the boundaries of the hot sphere, lung insert, and background ROIs (a). All images are linearly window-leveled from zero to six times the mean background intensity. The hot sphere contrast (Q) is plotted as a function of sphere diameter (b). The residual count error in the lung insert (Δ ) and image noise (CV) are plotted in (c). Images were reconstructed with the optimal reconstruction settings.

Image of FIG. 5.
FIG. 5.

ARCs as a function of sphere volume. The error bars indicate the estimated uncertainties (standard deviations) of the ARCs.

Image of FIG. 6.
FIG. 6.

The activity recovered in the whole-body ROIs (Aest) on the SPECT-DSW (a), SPECT-ppMC+DSW (b), and SPECT-fMC images (c), plotted as a function of the administered activity at time of scanning (A). The scout dose data points are depicted by circles and the treatment data points by squares. The solid lines represent the best linear fit (Aest = a × A + b) through the data points and the dashed lines represent the 95% confidence intervals (C.I.).

Image of FIG. 7.
FIG. 7.

Bar plots of the SPECT-DSW, SPECT-ppMC+DSW, and SPECT-fMC estimated mean absorbed doses in the nontumor and tumor ROIs of each patient. The standard deviations of the means are depicted by the error bars. Data points represent the peak absorbed doses in the tumor ROIs in accordance with PERCIST criteria.

Image of FIG. 8.
FIG. 8.

Transversal slices through the SPECT-DSW (top), SPECT-ppMC+DSW (middle), and SPECT-fMC (bottom) dose images of patient 5, fused with CT and overlaid with the tumor ROI boundaries (a). Cumulative dose-volume-histograms of the nontumor and tumor ROIs are shown in panel (b) to illustrate the dose distributions.

Tables

Generic image for table
TABLE I.

Energies and intensities of the betas (ß) and gamma photons (γ) of 166Ho decay. Data were obtained from the website of the National Nuclear Data Center (NNDC, Brookhaven National Laboratory, NY, http://www.nndc.bnl.gov).

Generic image for table
TABLE II.

Characteristics of the reconstruction algorithms.

Generic image for table
TABLE III.

Patient and treatment characteristics.

Loading

Article metrics loading...

/content/aapm/journal/medphys/40/11/10.1118/1.4823788
2013-10-10
2014-04-21
Loading

Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Quantitative Monte Carlo-based holmium-166 SPECT reconstruction
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/11/10.1118/1.4823788
10.1118/1.4823788
SEARCH_EXPAND_ITEM