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Functional magnetic resonance imaging with an ultrashort echo time
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10.1118/1.4773035
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    Affiliations:
    1 Department of Biomedical Engineering, Graduate College of Electronics and Information, Kyung Hee University, #1 Seocheon-dong, Giheung-gu, Youngin, Gyeonggi-do 446-701, South Korea
    2 Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #149 Sangil-dong, Gangdong-gu, Seoul 134-727, South Korea
    3 Department of Biomedical Engineering, Graduate College of Electronics and Information, Kyung Hee University, #1 Seocheon-dong, Giheung-gu, Youngin, Gyeonggi-do 446-701, South Korea
    4 Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #149 Sangil-dong, Gangdong-gu, Seoul 134-727, South Korea
    a) Author to whom correspondence should be addressed. Electronic mail: ghjahng@gmail.com; Telephone: 822-440-6187; Fax: 822-440-6932.
    Med. Phys. 40, 022301 (2013); http://dx.doi.org/10.1118/1.4773035
/content/aapm/journal/medphys/40/2/10.1118/1.4773035
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/2/10.1118/1.4773035

Figures

Image of FIG. 1.
FIG. 1.

Continuous slices of raw images of BOLD (a) and UTE (b) fMRI experiments obtained from a young female subject UTE images (b) provide better image quality than BOLD ones (a), especially in the frontal and temporal areas in the brain.

Image of FIG. 2.
FIG. 2.

Results of the visual stimulation in 17 subjects using UTE-based (a) and BOLD (b) methods Both UTE-based and BOLD results are observed with significance level of p < 0.05 for correcting multiple comparisons using a FDR. In the UTE-based data, decreased (blue) signal intensities were found during visual stimulation, and no increased signals were observed. In the BOLD data, increased (red) and decreased (blue) signal intensities were found during visual stimulation. The color-coded maps are overlaid on the standard axial T1 template.

Image of FIG. 3.
FIG. 3.

Results of normalized and averaged time-course signal intensities in all subjects for UTE-based data (a) and for BOLD data (b) UTE-based data were obtained from the left lingual gyrus (ROI 1) and BOLD data were obtained from the right lingual gyrus (ROI 2) in the occipital lobe. The UTE-based and BOLD signals were normalized to the mean signal of all time points. The lines at the bottom indicate the period of stimulation.

Image of FIG. 4.
FIG. 4.

Maps of the effect size calculated from one sample t-test for both UTE (a) and BOLD (b) data. To obtain the effect size, the AFNI (afni.nimh.nih.gov/afni/) program was used with considering multivoxel tests. The effect size was calculated using the Cohen's d equation in all voxels obtained from results of one sample t-test.

Tables

Generic image for table
TABLE I.

Brain regions of significantly decreased signals during the visual stimulation of the UTE-based fMRI method in all subjects.

Generic image for table
TABLE II.

Brain regions of significantly increased or decreased signals during the visual stimulation of the BOLD fMRI method in all subjects.

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/content/aapm/journal/medphys/40/2/10.1118/1.4773035
2013-01-07
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Functional magnetic resonance imaging with an ultrashort echo time
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/2/10.1118/1.4773035
10.1118/1.4773035
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