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First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation
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10.1118/1.4788661
/content/aapm/journal/medphys/40/2/10.1118/1.4788661
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/2/10.1118/1.4788661
View: Figures

Figures

Image of FIG. 1.
FIG. 1.

Experimental arrangement showing the liquid-metal-jet source, the rotatable object, and the detector. The source-to-object distance is R 1 and object-to-detector distance is R 2.

Image of FIG. 2.
FIG. 2.

Quantitative x-ray spectra of the Ga/In/Sn and In/Ga liquid-metal-jet sources, with 7 μm FWHM spot size, 200-μm-thick Al filtering and at 50 W e-beam power. The In/Ga spectrum has been shifted upwards.

Image of FIG. 3.
FIG. 3.

X-ray imaging and CT of a mouse using the Ga/In/Sn source. (a) A projection image of the mouse pelvic region and (b) a closeup of the knee. (c) The tomographically reconstructed slice through the mouse, where the dashed white line in (a) indicates the position of the slice. Motion blur artifacts are observed as a slight fog at the white arrow. (d) A closeup of the spine and pelvis. (e) A closeup showing 50 μm wide details in the trabecular bone. Distances: R 1 = 0.49 m and R 2 = 0.11 m. Exposure time and dose: (a) and (b) 20 s and 5.6 mGy, (c)–(e) 1 h and 1.0 Gy.

Image of FIG. 4.
FIG. 4.

Segmented and surface-rendered representation of the absorption-CT dataset for the bones in the pelvic region of the nude mouse in Fig. 3 .

Image of FIG. 5.
FIG. 5.

X-ray projection image of a mouse, using the new In/Ga liquid-metal-jet x-ray source. The distances R 1 = 2.4 m and R 2 = 0.5 m results in a phase-contrast contribution to the image. Exposure time and dose: 240 s and 2.3 mGy.

Image of FIG. 6.
FIG. 6.

(a) X-ray phase-contrast image of a mouse tumor. The black arrows indicate the position of the boundary between the tumor (T) and surrounding fat tissue (F). The dark areas are bone (B). (b) Absorption CT of the same mouse. The slice corresponds to the position of the dashed white line in (a) and the arrows point at the same tumor interface as in (a). Ga/In/Sn source. Distances: (a) R 1 = 1 m and R 2 = 2 m, (b) R 1 = 0.385 m, and R 2 = 0.115 m. Exposure time and dose: (a) 300 s and 19 mGy, (b) 45 min and 1.3 Gy.

Image of FIG. 7.
FIG. 7.

Comparison between phase-contrast and absorption-contrast tumor imaging at approximately the same dose. (a) Part of the Fig. 6(a) phase-contrast image at 19 mGy. (b) Same area in absorption at 15 mGy. Ga/In/Sn source. Distances: (a) R 1 = 1 m and R 2 = 2 m, (b) R 1 = 0.385 m, and R 2 = 0.115 m. Exposure time: (a) 300 s, (b) 30 s.

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/content/aapm/journal/medphys/40/2/10.1118/1.4788661
2013-01-24
2014-04-16
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/2/10.1118/1.4788661
10.1118/1.4788661
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