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CT-perfusion versus [15O]H2O PET in lung tumors: Effects of CT-perfusion methodology
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10.1118/1.4798560
/content/aapm/journal/medphys/40/5/10.1118/1.4798560
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/5/10.1118/1.4798560
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Figures

Image of FIG. 1.
FIG. 1.

Per kinetic analysis method all the ICCs, R, and slopes obtained when applying dynamic contouring thresholds on threshold derived VOIs are plotted. Nonsmoothed (left columns) and smoothed (right columns) data were separated. In most cases the nonsmoothed data have a wider distribution, however, the nonsmoothed data showed better combinations of ICC, R, and slopes. The Patlak method showed no positive ICCs for any combination of thresholds.

Image of FIG. 2.
FIG. 2.

CT perfusion calculated using the slope method plotted against [O]HO PET. Dynamic contouring thresholds of −200 HU (lower) and +500 HU (upper) were applied on the dynamic CT data. ICC: 0.83; R: 0.90; and Y: 0.70 (LOI: Line of interest).

Image of FIG. 3.
FIG. 3.

A Bland-Altman plot obtained using the data points from the correlation between the CTP (Slope method) (dynamic contouring thresholds: −200 and +500 HU) and [O]HO PET (Fig. 2 ).

Image of FIG. 4.
FIG. 4.

This graph shows the effect of dynamic lower border thresholds. Tumor movement causes two large variabilities in tumor enhancement when no threshold is applied (1). After dynamic lower border thresholds were applied, −300 (2) and −200 (3), the tumor CT_TAC improved. The use of dynamic lower threshold of −300 showed the best agreement of CT derived perfusion values with the use [O]HO PET.

Image of FIG. 5.
FIG. 5.

A gamma curve fitted through the arterial (a) and tumor CT_TAC (b). The Slope and Mullani-Gould method used the gamma curve to calculate perfusion; STM fitted through the tumor CT_TAC (c); Patlak Plot plotted using the tumor CT_TAC (d) (Int arterial: Integral of arterial TAC).

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/content/aapm/journal/medphys/40/5/10.1118/1.4798560
2013-04-17
2014-04-19
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: CT-perfusion versus [15O]H2O PET in lung tumors: Effects of CT-perfusion methodology
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/5/10.1118/1.4798560
10.1118/1.4798560
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