Schematic view of the entire PET/SPECT/CT system, showing its main geometric parameters.
(a) Schematic view of the single pinhole collimator with a knife-edge type aperture. (b) Schematic view of multi-pinhole configuration, with tilted apertures. b 1 refers to the minimum distance such that the center of the FOV can be seen by all the apertures. b 2 refers to the radius of rotation (FOV20, FOV40, FOV60, and FOV80 b 2 = 20, 32, 47, and 66 mm, respectively).
The small animal whole system PET/SPECT/CT.
Derenzo-like phantoms used for SPECT spatial resolution determination. (a) Phantom used for axial resolution for FOV20 and FOV40. (b) Phantom used for transaxial resolution for FOV20 and FOV40. (c) Phantom used for FOV60 and FOV80. Numbers in the images refer to the diameter in mm of the drilled tubes.
Measured MTF curve of the CT subsystem using a gold wire 50 μm in diameter placed in the center of the FOV.
(a)Variation of SPECT sensitivity with the energy window for the single- and multi-pinhole collimator at the FOV20 configuration. (b) SPECT sensitivity variation with the FOV for single- and multi-pinhole collimator configuration. The energy window is set to ±15%.
(a) Transaxial spatial resolution for the SPECT subsystem for the single- and multi-pinhole configuration at different FOVs. Although not showed, no significant differences are observed for the axial component. (b) Transaxial profile of the 0.8 mm diameter line sources obtained with the transaxial resolution phantom [Fig. 4(b) ] using the single-pinhole collimator and FOV20 configuration. See the text for h1, h2, and h3 meaning. (c) Reconstructed image in the transaxial plane of the phantom of Fig. 4(b) using the single-pinhole and FOV20 configuration, voxel size 0.25 × 0.25 × 0.25 mm3. (d) Same as (c) but using the multi-pinhole with voxel size of 0.35 × 0.35 × 0.35 mm3. In (c) and (d), the central slice is shown.
Trimodal in vivo imaging of a mouse obtained by using 99mTc-MDP (SPECT) and Na18F (PET) as tracers. Up (from left to right): CT, PET, and fused PET/CT. Down (from left to right): SPECT, fused SPECT/CT, and fused PET/SPECT/CT image.
ALBIRA CT working configurations.
DEV(%) and N(%) obtained with the CT for different configurations.
ALBIRA PET/SPECT/CT system performance compared with other trimodal systems commercially available.
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