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ALBIRA: A small animal PET/SPECT/CT imaging system
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Image of FIG. 1.
FIG. 1.

Schematic view of the entire PET/SPECT/CT system, showing its main geometric parameters.

Image of FIG. 2.
FIG. 2.

(a) Schematic view of the single pinhole collimator with a knife-edge type aperture. (b) Schematic view of multi-pinhole configuration, with tilted apertures. refers to the minimum distance such that the center of the FOV can be seen by all the apertures. refers to the radius of rotation (FOV20, FOV40, FOV60, and FOV80 = 20, 32, 47, and 66 mm, respectively).

Image of FIG. 3.
FIG. 3.

The small animal whole system PET/SPECT/CT.

Image of FIG. 4.
FIG. 4.

Derenzo-like phantoms used for SPECT spatial resolution determination. (a) Phantom used for axial resolution for FOV20 and FOV40. (b) Phantom used for transaxial resolution for FOV20 and FOV40. (c) Phantom used for FOV60 and FOV80. Numbers in the images refer to the diameter in mm of the drilled tubes.

Image of FIG. 5.
FIG. 5.

Measured MTF curve of the CT subsystem using a gold wire 50 m in diameter placed in the center of the FOV.

Image of FIG. 6.
FIG. 6.

(a)Variation of SPECT sensitivity with the energy window for the single- and multi-pinhole collimator at the FOV20 configuration. (b) SPECT sensitivity variation with the FOV for single- and multi-pinhole collimator configuration. The energy window is set to ±15%.

Image of FIG. 7.
FIG. 7.

(a) Transaxial spatial resolution for the SPECT subsystem for the single- and multi-pinhole configuration at different FOVs. Although not showed, no significant differences are observed for the axial component. (b) Transaxial profile of the 0.8 mm diameter line sources obtained with the transaxial resolution phantom [Fig. 4(b) ] using the single-pinhole collimator and FOV20 configuration. See the text for h, h, and h meaning. (c) Reconstructed image in the transaxial plane of the phantom of Fig. 4(b) using the single-pinhole and FOV20 configuration, voxel size 0.25 × 0.25 × 0.25 mm. (d) Same as (c) but using the multi-pinhole with voxel size of 0.35 × 0.35 × 0.35 mm. In (c) and (d), the central slice is shown.

Image of FIG. 8.
FIG. 8.

Trimodal imaging of a mouse obtained by using Tc-MDP (SPECT) and NaF (PET) as tracers. Up (from left to right): CT, PET, and fused PET/CT. Down (from left to right): SPECT, fused SPECT/CT, and fused PET/SPECT/CT image.


Generic image for table

ALBIRA CT working configurations.

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DEV(%) and N(%) obtained with the CT for different configurations.

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ALBIRA PET/SPECT/CT system performance compared with other trimodal systems commercially available.


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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: ALBIRA: A small animal PET/SPECT/CT imaging system