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1. H. E. Cline, J. F. Schenck, K. Hynynen, R. D. Watkins, S. P. Souza, and F. A. Jolesz, “MR-guided focused ultrasound surgery,” J. Comput. Assist. Tomogr. 16, 956965 (1992).
2. K. Hynynen, A. Darkazanli, E. Unger, and J. F. Schenck, “MRI-guided noninvasive ultrasound surgery,” Med. Phys. 20, 107115 (1993).
3. R. M. Arthur, W. L. Straube, J. W. Trobaugh, and E. G. Moros, “Non-invasive estimation of hyperthermia temperatures with ultrasound,” Int. J. Hyperthermia 21, 589600 (2005).
4. S. Vaezy, X. Shi, R. W. Martin, E. Chi, P. I. Nelson, M. R. Bailey, and L. A. Crum, “Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging,” Ultrasound Med. Biol. 27, 3342 (2001).
5. C. Maleke and E. E. Konofagou, “An all-ultrasound-based system for real-time monitoring and sonication of temperature change and ablation,” Conf. Proc. IEEE Eng. Med. Biol. Soc. 1, 164167 (2006).
6. A. N. Guthkelch et al., “Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: Results of a phase I trial,” J. Neurooncol. 10, 271284 (1991).
7. T. Uchida, S. Shoji, M. Nakano, S. Hongo, M. Nitta, Y. Usui, and Y. Nagata, “High-intensity focused ultrasound as salvage therapy for patients with recurrent prostate cancer after external beam radiation, brachytherapy or proton therapy,” BJU Int. 107, 378382 (2011).
8. M. Kinoshita, N. McDannold, F. A. Jolesz, and K. Hynynen, “Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound,” Biochem. Biophys. Res. Commun. 340, 10851090 (2006).
9. L. Grossman, C. Brock-Abraham, N. Carbone, E. Dodds, J. Kluger, A. Park, N. Rawlings, C. Suddath, F. Sun, M. Thompson, B. Walsh, and K. Webley, “The 50 best inventions,” Time (Time, Inc., New York, 2011).
10. L. Whitaker, “Body & mind: Giving fibroids the heat,” Time (Time, Inc., New York, 2006).
11. K. Hynynen, C. Damianou, A. Darkazanli, E. Unger, and J. F. Schenck, “The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery,” Ultrasound Med. Biol. 19, 9192 (1993).
12. F. A. Jolesz and N. McDannold, “Current status and future potential of MRI-guided focused ultrasound surgery,” J. Magn. Reson. Imaging 27, 391399 (2008).
13. C. J. Diederich, R. J. Stafford, W. H. Nau, E. C. Burdette, R. E. Price, and J. D. Hazle, “Transurethral ultrasound applicators with directional heating patterns for prostate thermal therapy: In vivo evaluation using magnetic resonance thermometry,” Med. Phys. 31, 405413 (2004).
14. T. S. Curry, J. E. Dowdey, and R. C. Murray, Christensen's Physics of Diagnostic Radiology, 4th ed. (Lippincott Williams & Wilkins, Philadelphia, PA, 1990).
15. N. B. Smith and A. Webb, Introduction to Medical Imaging: Physics, Engineering, and Clinical Applications. (Cambridge University Press, New York, 2011).
16. G. T. Haar and C. Coussios, “High intensity focused ultrasound: Physical principles and devices,” Int. J. Hyperthermia 23, 89104 (2007).
17. V. Zderic, A. Keshavarzi, M. A. Andrew, S. Vaezy, and R. W. Martin, “Attenuation of porcine tissues in vivo after high-intensity ultrasound treatment,” Ultrasound Med. Biol. 30, 6166 (2004).
18. G. A. Ferraro, F. De Francesco, G. Nicoletti, F. Rossano, and F. D’Andrea, “Histologic effects of external ultrasound-assisted lipectomy on adipose tissue,” Aesthetic Plast. Surg. 32, 111115 (2008).
19. M. L. Jewell, N. J. Solish, and C. S. Desilets, “Noninvasive body sculpting technologies with an emphasis on high-intensity focused ultrasound,” Aesthetic Plast. Surg. 35, 901912 (2011).
20. S. E. Burgess, T. Iwamoto, D. J. Coleman, F. L. Lizzi, J. Driller, and A. Rosado, “Histologic changes in porcine eyes treated with high-intensity focused ultrasound,” Ann. Ophthalmol. 19, 133138 (1987).
21. D. J. Coleman, F. L. Lizzi, J. H. Torpey, S. E. Burgess, J. Driller, A. Rosado, and H. T. Nguyen, “Treatment of experimental lens capsular tears with intense focused ultrasound,” Br. J. Ophthalmol. 69, 645649 (1985).
22. R. H. Silverman, B. Vogelsang, M. J. Rondeau, and D. J. Coleman, “Therapeutic ultrasound for the treatment of glaucoma,” Am. J. Ophthalmol. 111, 327337 (1991).
23. B. D. de Senneville, C. Mougenot, B. Quesson, I. Dragonu, N. Grenier, and C. T. Moonen, “MR thermometry for monitoring tumor ablation,” Eur. Radiol. 17, 24012410 (2007).
24. Y. Ishihara, A. Calderon, H. Watanabe, K. Okamoto, Y. Suzuki, and K. Kuroda, “A precise and fast temperature mapping using water proton chemical shift,” Magn. Reson. Med. 34, 814823 (1995).
25. V. Rieke and K. Butts Pauly, “MR thermometry,” J. Magn. Reson. Imaging 27, 376390 (2008).
26. R. D. Peters, R. S. Hinks, and R. M. Henkelman, “Ex vivo tissue-type independence in proton-resonance frequency shift MR thermometry,” Magn. Reson. Med. 40, 454459 (1998).
27. A. B. Holbrook, J. M. Santos, E. Kaye, V. Rieke, and K. B. Pauly, “Real-time MR thermometry for monitoring HIFU ablations of the liver,” Magn. Reson. Med. 63, 365373 (2010).
28. B. D. de Senneville, S. Roujol, C. Moonen, and M. Ries, “Motion correction in MR thermometry of abdominal organs: A comparison of the referenceless vs. the multibaseline approach,” Magn. Reson. Med. 64, 13731381 (2010).
29. B. Quesson, C. Laurent, G. Maclair, B. D. de Senneville, C. Mougenot, M. Ries, T. Carteret, A. Rullier, and C. T. Moonen, “Real-time volumetric MRI thermometry of focused ultrasound ablation in vivo: a feasibility study in pig liver and kidney,” NMR Biomed. 24, 145153 (2011).
30. K. Kuroda, K. Oshio, R. V. Mulkern, and F. A. Jolesz, “Optimization of chemical shift selective suppression of fat,” Magn. Reson. Med. 40, 505510 (1998).
31. J. A. de Zwart, F. C. Vimeux, C. Delalande, P. Canioni, and C. T. Moonen, “Fast lipid-suppressed MR temperature mapping with echo-shifted gradient-echo imaging and spectral-spatial excitation,” Magn. Reson. Med. 42, 5359 (1999).<53::AID-MRM9>3.0.CO;2-S
32. H. E. Cline, K. Hynynen, C. J. Hardy, R. D. Watkins, J. F. Schenck, and F. A. Jolesz, “MR temperature mapping of focused ultrasound surgery,” Magn. Reson. Med. 31, 628636 (1994).
33. K. Hynynen, N. I. Vykhodtseva, A. H. Chung, V. Sorrentino, V. Colucci, and F. A. Jolesz, “Thermal effects of focused ultrasound on the brain: Determination with MR imaging,” Radiology 204, 247253 (1997).
34. N. McDannold, C. Tempany, F. Jolesz, and K. Hynynen, “Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids,” J. Magn. Reson. Imaging 28, 10261032 (2008).
35. J. Overgaard, “Historical perspectives of hyperthermia,” in Introduction to Hyperthermic Oncology, edited by J. Overgaard (Taylor & Francis, London, 1984), Vol. 2.
36. H. Chen, X. Li, and M. Wan, “The inception of cavitation bubble clouds induced by high-intensity focused ultrasound,” Ultrasonics 44(1), e427e429 (2006).
37. C. C. Coussios, C. H. Farny, G. Ter Haar, and R. A. Roy, “Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU),” Int. J. Hyperthermia 23, 105120 (2007).
38. P. Hariharan, M. R. Myers, R. A. Robinson, S. H. Maruvada, J. Sliwa, and R. K. Banerjee, “Characterization of high intensity focused ultrasound transducers using acoustic streaming,” J. Acoust. Soc. Am. 123, 17061719 (2008).
39. M. R. Myers, P. Hariharan, and R. K. Banerjee, “Direct methods for characterizing high-intensity focused ultrasound transducers using acoustic streaming,” J. Acoust. Soc. Am. 124, 17901802 (2008).
40. E. J. Hall and A. J. Giaccia, Radiobiology for the Radiologist (Lippincott Williams & Wilkins, Philadelphia, PA, 2006).
41. V. Frenkel, J. Oberoi, M. J. Stone, M. Park, C. Deng, B. J. Wood, Z. Neeman, M. Horne III, and K. C. Li, “Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model,” Radiology 239, 8693 (2006).
42. K. Hynynen, V. Colucci, A. Chung, and F. Jolesz, “Noninvasive arterial occlusion using MRI-guided focused ultrasound,” Ultrasound Med. Biol. 22, 10711077 (1996).
43. S. Vaezy and V. Zderic, “Hemorrhage control using high intensity focused ultrasound,” Int. J. Hyperthermia 23, 203211 (2007).
44. V. G. Petin, V. P. Komarov, and V. G. Skvortzov, “Combined action of ultrasound and ionizing radiation on yeast cells,” Radiat. Environ. Biophys. 18, 4555 (1980).
45. J. Overgaard, “The biological bases for the clinical application of hyperthermia as an adjuvant to radiotherapy,” Prog. Clin. Biol. Res. 132D, 205216 (1983).
46. M. D. Hurwitz, “Today's thermal therapy: Not your father's hyperthermia: Challenges and opportunities in application of hyperthermia for the 21st century cancer patient,” Am. J. Clin. Oncol. 33, 96100 (2010).
47. Y. F. Zhou, “High intensity focused ultrasound in clinical tumor ablation,” World J. Clin. Oncol. 2, 827 (2011).
48. M. Ward, J. Wu, and J. F. Chiu, “Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents,” J. Acoust. Soc. Am. 105, 29512957 (1999).
49. N. McDannold, N. Vykhodtseva, S. Raymond, F. A. Jolesz, and K. Hynynen, “MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits,” Ultrasound Med. Biol. 31, 15271537 (2005).
50. V. Frenkel and K. C. Li, “Potential role of pulsed-high intensity focused ultrasound in gene therapy,” Future Oncol. 2, 111119 (2006).
51. R. Wood and A. Loomis, “The physical and biological effects of high frequency sound waves of great intensity,” London Edinburgh Dublin Philos. Mag. J. Sci. 1927, 417436 (1927).
52. J. G. Lynn and T. J. Putnam, “Histology of cerebral lesions produced by focused ultrasound,” Am. J. Pathol. 20, 637649 (1944).
53. W. J. Fry, W. H. Mosberg Jr., J. W. Barnard, and F. J. Fry, “Production of focal destructive lesions in the central nervous system with ultrasound,” J, Neurosurg 11, 471478 (1954).
54. P. P. Lele, “Production of deep focal lesions by focused ultrasound–Current status,” Ultrasonics 5, 105112 (1967).
55. F. J. Fry and L. K. Johnson, “Tumor irradiation with intense ultrasound,” Ultrasound Med. Biol. 4, 337341 (1978).
56. L. Leksell, “The stereotaxic method and radiosurgery of the brain,” Acta Chir. Scand. 102, 316319 (1951).
57. F. J. Fry and J. E. Barger, “Acoustical properties of the human skull,” J. Acoust. Soc. Am. 63, 15761590 (1978).
58. F. J. Fry, S. A. Goss, and J. T. Patrick, “Transkull focal lesions in cat brain produced by ultrasound,” J. Neurosurg. 54, 659663 (1981).
59. K. Hynynen and F. A. Jolesz, “Demonstration of potential noninvasive ultrasound brain therapy through an intact skull,” Ultrasound Med. Biol. 24, 275283 (1998).
60. D. J. Phillips, S. W. Smith, O. T. Ramm, and F. L. Thurstone, “A phase compensation technique for B-mode echoencephalography,” in Ultrasound in Medicine, edited by D. White (Plenum Press, New York, 1975), pp. 395404.
61. D. L. Parker, V. Smith, P. Sheldon, L. E. Crooks, and L. Fussell, “Temperature distribution measurements in two-dimensional NMR imaging,” Med. Phys. 10, 321325 (1983).
62. S. Madersbacher, M. Susani, and M. Marberger, “Thermal ablation of BPH with transrectal high-intensity focused ultrasound,” Prog. Clin. Biol. Res. 386, 473478 (1994).
63. A. Gelet, J. Y. Chapelon, R. Bouvier, R. Souchon, C. Pangaud, A. F. Abdelrahim, D. Cathignol, and J. M. Dubernard, “Treatment of prostate cancer with transrectal focused ultrasound: Early clinical experience,” Eur. Urol. 29, 174183 (1996).
64. J. Y. Chapelon, M. Ribault, F. Vernier, R. Souchon, and A. Gelet, “Treatment of localised prostate cancer with transrectal high intensity focused ultrasound,” Eur. J. Ultrasound 9, 3138 (1999).
65. H. E. Cline, K. Hynynen, R. D. Watkins, W. J. Adams, J. F. Schenck, R. H. Ettinger, W. R. Freund, J. P. Vetro, and F. A. Jolesz, “Focused US system for MR imaging-guided tumor ablation,” Radiology 194, 731737 (1995).
66. G. T. Clement, J. White, and K. Hynynen, “Investigation of a large-area phased array for focused ultrasound surgery through the skull,” Phys. Med. Biol. 45, 10711083 (2000).
67. J. F. Aubry, M. Tanter, J. Gerber, J. L. Thomas, and M. Fink, “Optimal focusing by spatio-temporal inverse filter. II. Experiments. Application to focusing through absorbing and reverberating media,” J. Acoust. Soc. Am. 110, 4858 (2001).
68. F. Wu, Z. B. Wang, W. Z. Chen, H. Zhu, J. Bai, J. Z. Zou, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma,” Ann. Surg. Oncol. 11, 10611069 (2004).
69. F. Wu, Z. B. Wang, W. Z. Chen, J. Bai, H. Zhu, and T. Y. Qiao, “Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy,” J. Urol. 170, 22372240 (2003).
70. W. Chen, Z. Wang, F. Wu, H. Zhu, J. Zou, J. Bai, K. Li, and F. Xie, “High intensity focused ultrasound in the treatment of primary malignant bone tumor,” Zhonghua Zhong Liu Za Zhi 24, 612615 (2002).
71. F. Wu, Z. B. Wang, H. Zhu, W. Z. Chen, J. Z. Zou, J. Bai, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Feasibility of US-guided high-intensity focused ultrasound treatment in patients with advanced pancreatic cancer: Initial experience,” Radiology 236, 10341040 (2005).
72. F. Wu, W. Z. Chen, J. Bai, J. Z. Zou, Z. L. Wang, H. Zhu, and Z. B. Wang, “Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound,” Ultrasound Med. Biol. 27, 10991106 (2001).
73. W. Chen, Z. Wang, F. Wu, J. Bai, H. Zhu, J. Zou, K. Li, and F. Xie, “High intensity focused ultrasound alone for malignant solid tumors,” Zhonghua Zhong Liu Za Zhi 24, 278281 (2002).
74. F. Wu, Z. B. Wang, W. Z. Chen, W. Wang, Y. Gui, M. Zhang, G. Zheng, Y. Zhou, G. Xu, M. Li, C. Zhang, H. Ye, and R. Feng, “Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: An overview,” Ultrason. Sonochem. 11, 149154 (2004).
75. S. Fujishiro, M. Mitsumori, Y. Nishimura, Y. Okuno, Y. Nagata, M. Hiraoka, T. Sano, T. Marume, and N. Takayama, “Increased heating efficiency of hyperthermia using an ultrasound contrast agent: A phantom study,” Int. J. Hyperthermia 14, 495502 (1998).
76. T. Yu, G. Wang, K. Hu, P. Ma, J. Bai, and Z. Wang, “A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: A rabbit kidney study,” Urol. Res. 32, 1419 (2004).
77. Z. M. Lenard, N. J. McDannold, F. M. Fennessy, E. A. Stewart, F. A. Jolesz, K. Hynynen, and C. M. Tempany, “Uterine leiomyomas: MR imaging-guided focused ultrasound surgery–imaging predictors of success,” Radiology 249, 187194 (2008).
78. K. Funaki, H. Fukunishi, T. Funaki, K. Sawada, Y. Kaji, and T. Maruo, “Magnetic resonance-guided focused ultrasound surgery for uterine fibroids: Relationship between the therapeutic effects and signal intensity of preexisting T2-weighted magnetic resonance images,” Am. J. Obstet. Gynecol. 196, 184e1184e6 (2007).
79. F. A. Taran, C. M. Tempany, L. Regan, Y. Inbar, A. Revel, and E. A. Stewart, “Magnetic resonance-guided focused ultrasound (MRgFUS) compared with abdominal hysterectomy for treatment of uterine leiomyomas,” Ultrasound Obstet. Gynecol. 34, 572578 (2009).
80. S. Zaher, W. M. Gedroyc, and L. Regan, “Patient suitability for magnetic resonance guided focused ultrasound surgery of uterine fibroids,” Eur. J. Obstet. Gynecol. Reprod. Biol. 143, 98102 (2009).
81. C. Ripamonti and F. Fulfaro, “Malignant bone pain: Pathophysiology and treatments,” Curr. Rev. Pain. 4, 187196 (2000).
82. R. Catane, A. Beck, Y. Inbar, T. Rabin, N. Shabshin, S. Hengst, R. M. Pfeffer, A. Hanannel, O. Dogadkin, B. Liberman, and D. Kopelman, “MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases–Preliminary clinical experience,” Ann. Oncol. 18, 163167 (2007).
83. D. Gianfelice, C. Gupta, W. Kucharczyk, P. Bret, D. Havill, and M. Clemons, “Palliative treatment of painful bone metastases with MR imaging–Guided focused ultrasound,” Radiology 249, 355363 (2008).
84. B. Liberman, D. Gianfelice, Y. Inbar, A. Beck, T. Rabin, N. Shabshin, G. Chander, S. Hengst, R. Pfeffer, A. Chechick, A. Hanannel, O. Dogadkin, and R. Catane, “Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: A multicenter study,” Ann. Surg. Oncol. 16, 140146 (2009).
85. T. D. Khokhlova, M. S. Canney, D. Lee, K. I. Marro, L. A. Crum, V. A. Khokhlova, and M. R. Bailey, “Magnetic resonance imaging of boiling induced by high intensity focused ultrasound,” J. Acoust. Soc. Am. 125, 24202431 (2009).
86. V. A. Khokhlova, M. R. Bailey, J. A. Reed, B. W. Cunitz, P. J. Kaczkowski, and L. A. Crum, “Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom,” J. Acoust. Soc. Am. 119, 18341848 (2006).
87. S. D. Sokka, R. King, and K. Hynynen, “MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh,” Phys. Med. Biol. 48, 223241 (2003).
88. B. Werner, A. Morel, E. Zadicario, D. Jeanmonod, and E. Martin, “Transcranial MR-guided high intensity focused ultrasound for non-invasive functional neurosurgery,” AIP Conf. Proc. 1215, 101104 (2010).
89. E. Makariou and A. D. Patsalides, “Intracranial calcifiations,” Appl. Radiol. 38, 4850 (2009).
90. S. C. Tang and G. T. Clement, “Standing-wave suppression for transcranial ultrasound by random modulation,” IEEE Trans. Biomed. Eng. 57, 203205 (2010).
91. E. Hipp, A. Partanen, G. S. Karczmar, and X. Fan, “Safety limitations of MR-HIFU treatment near interfaces: a phantom validation,” J. Appl. Clin. Med. Phys. 13, 168175 (2012).
92. M. A. O’Reilly, Y. Huang, and K. Hynynen, “The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model,” Phys. Med. Biol. 55, 52515267 (2010).
93. M. Daffertshofer, A. Gass, P. Ringleb, M. Sitzer, U. Sliwka, T. Els, O. Sedlaczek, W. J. Koroshetz, and M. G. Hennerici, “Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: Increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: Results of a phase II clinical trial,” Stroke 36, 14411446 (2005).
94. C. Baron, J. F. Aubry, M. Tanter, S. Meairs, and M. Fink, “Simulation of intracranial acoustic fields in clinical trials of sonothrombolysis,” Ultrasound Med. Biol. 35, 11481158 (2009).
95. A. Shaw and G. ter Haar, “Requirements for measurement standards in high intensity focused ultrasound (HIFU) fields,” National Physics Laboratory, Report DQL AC 015, 7–71 (2006).
96. A. Shaw and M. Hodnett, “Calibration and measurement issues for therapeutic ultrasound,” Ultrasonics 48, 234252 (2008).
97. M. W. Dewhirst, B. L. Viglianti, M. Lora-Michiels, M. Hanson, and P. J. Hoopes, “Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia,” Int. J. Hyperthermia 19, 267294 (2003).
98. K. R. Gorny, N. J. Hangiandreou, G. K. Hesley, B. S. Gostout, K. P. McGee, and J. P. Felmlee, “MR guided focused ultrasound: Technical acceptance measures for a clinical system,” Phys. Med. Biol. 51, 31553173 (2006).
99. M. Gyongy and C. C. Coussios, “Passive spatial mapping of inertial cavitation during HIFU exposure,” IEEE Trans. Biomed. Eng. 57, 4856 (2010).
100. F. Burdin, N. A. Tsochatzidis, P. Guiraud, A. M. Wilhelm, and H. Delmas, “Characterisation of the acoustic cavitation cloud by two laser techniques,” Ultrason. Sonochem. 6, 4351 (1999).
101. A. J. Coleman, M. J. Choi, and J. E. Saunders, “Detection of acoustic emission from cavitation in tissue during clinical extracorporeal lithotripsy,” Ultrasound Med. Biol. 22, 10791087 (1996).
102. R. O. Cleveland, O. A. Sapozhnikov, M. R. Bailey, and L. A. Crum, “A dual passive cavitation detector for localized detection of lithotripsy-induced cavitation in vitro,” J. Acoust. Soc. Am. 107, 17451758 (2000).
103. J. Gateau, J. F. Aubry, M. Pernot, M. Fink, and M. Tanter, “Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 58, 517532 (2011).
104. A. Waldman, J. H. Rees, C. S. Brock, M. D. Robson, P. D. Gatehouse, and G. M. Bydder, “MRI of the brain with ultra-short echo-time pulse sequences,” Neuroradiology 45, 887892 (2003).
105. S. Okada, Y. Ohaki, K. Inoue, T. Kawamura, T. Hayashi, T. Kato, and T. Kumazaki, “Calcifications in mucinous and serous cystic ovarian tumors,” J. Nihon Med. Sch. 72, 2933 (2005).
106. S. M. Ribeiro, S. A. Ajzen, and J. C. Trindade, “Comparison of imaging methods for diagnosis of renal tumors and their calcifications,” Rev. Assoc. Med. Bras. 50, 403412 (2004).
107. H. Imhof and P. Frank, “Pancreatic calcifications in malignant islet cell tumors,” Radiology 122, 333337 (1977).
108. J. Dziukowa, “Importance of radiologically detectable calcifications in the diagnosis of thyroid tumors,” Pol. Med. J. 11, 890897 (1972).
109. D. Schiffer, F. Sibour, and C. Vesco, “Pathogenesis and significance of calcifications in cerebral tumors,” Minerva Neurochir. 5, 129130 (1961).
110. R. Leborgne, “Diagnosis of tumors of the breast by simple roentgenography; calcifications in carcinomas,” Am. J. Roentgenol. Radium. Ther 65, 111 (1951).
111. S. A. Sapareto, “Thermal isoeffect dose: Addressing the problem of thermotolerance,” Int. J. Hyperthermia 3, 297305 (1987).
112. M. J. Borrelli, L. L. Thompson, C. A. Cain, and W. C. Dewey, “Time-temperature analysis of cell killing of BHK cells heated at temperatures in the range of 43.5 degrees C to 57.0 degrees C,” Int. J. Radiat. Oncol. Biol. Phys. 19, 389399 (1990).
113. J. Pearce, “Mathematical models of laser-induced tissue thermal damage,” Int. J. Hyperthermia 27, 741750 (2011).
114. J. A. Pearce, “Relationship between Arrhenius models of thermal damage and the CEM 43 thermal dose,” Proc. SPIE 7181, 718104 (2009).
115. ICRP, “1990 Recommendations of the international commission on radiological protection. ICRP Publication 60,” Ann. ICRP 21, 1201 (1991).
116. G. G. Raab and D. H. Parr, “From medical invention to clinical practice: The reimbursement challenge facing new device procedures and technology–Part 2: Coverage,” J. Am. Coll. Radiol. 3, 772777 (2006).
117. G. G. Raab and D. H. Parr, “From medical invention to clinical practice: the reimbursement challenge facing new device procedures and technology–part 3: Payment,” J. Am. Coll. Radiol. 3, 842850 (2006).
118. M. Warmuth, T. Johansson, and P. Mad, “Systematic review of the efficacy and safety of high-intensity focussed ultrasound for the primary and salvage treatment of prostate cancer,” Eur. Urol. 58, 803815 (2010).
119. S. H. Benedict, G. De Meerleer, C. G. Orton, and J. Stancanello, “Point/counterpoint. High intensity focused ultrasound may be superior to radiation therapy for the treatment of early stage prostate cancer,” Med. Phys. 38, 39093912 (2011).
120. K. Hynynen, O. Pomeroy, D. N. Smith, P. E. Huber, N. J. McDannold, J. Kettenbach, J. Baum, S. Singer, and F. A. Jolesz, “MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study,” Radiology 219, 176185 (2001).
121. D. Gianfelice, A. Khiat, M. Amara, A. Belblidia, and Y. Boulanger, “MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings,” Breast Cancer Res. Treat. 82, 93101 (2003).
122. F. Wu, Z. B. Wang, H. Zhu, W. Z. Chen, J. Z. Zou, J. Bai, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer,” Breast Cancer Res. Treat. 92, 5160 (2005).
123. H. Furusawa, K. Namba, H. Nakahara, C. Tanaka, Y. Yasuda, E. Hirabara, M. Imahariyama, and K. Komaki, “The evolving non-surgical ablation of breast cancer: MR guided focused ultrasound (MRgFUS),” Breast Cancer 14, 5558 (2007).
124. D. B. Zippel and M. Z. Papa, “The use of MR imaging guided focused ultrasound in breast cancer patients; a preliminary phase one study and review,” Breast Cancer 12, 3238 (2005).
125. D. R. Brenin, “Focused ultrasound ablation for the treatment of breast cancer,” Ann. Surg. Oncol. 18, 30883094 (2011).
126. B. C. McCormick, “The politics and the ethics of breast cancer,” Brachytherapy 2, 119120 (2003).
127. S. Crouzet, X. Rebillard, D. Chevallier, P. Rischmann, G. Pasticier, G. Garcia, O. Rouviere, J. Y. Chapelon, and A. Gelet, “Multicentric oncologic outcomes of high-intensity focused ultrasound for localized prostate cancer in 803 patients,” Eur. Urol. 58, 559566 (2010).
128. T. Uchida, H. Ohkusa, H. Yamashita, S. Shoji, Y. Nagata, T. Hyodo, and T. Satoh, “Five years experience of transrectal high-intensity focused ultrasound using the Sonablate device in the treatment of localized prostate cancer,” Int. J. Urol. 13, 228233 (2006).
129. E. Zacharakis, H. U. Ahmed, A. Ishaq, R. Scott, R. Illing, A. Freeman, C. Allen, and M. Emberton, “The feasibility and safety of high-intensity focused ultrasound as salvage therapy for recurrent prostate cancer following external beam radiotherapy,” BJU Int. 102, 786792 (2008).
130. V. Chalasani, C. H. Martinez, D. Lim, and J. Chin, “Salvage HIFU for recurrent prostate cancer after radiotherapy,” Prostate Cancer Prostatic Dis. 12, 124129 (2009).
131. G. Pasticier, O. Chapet, L. Badet, J. M. Ardiet, L. Poissonnier, F. J. Murat, X. Martin, and A. Gelet, “Salvage radiotherapy after high-intensity focused ultrasound for localized prostate cancer: early clinical results,” Urology 72, 13051309 (2008).
132. E. Liatsikos, B. Bynens, R. Rabenalt, P. Kallidonis, M. Do, and J. U. Stolzenburg, “Treatment of patients after failed high intensity focused ultrasound and radiotherapy for localized prostate cancer: salvage laparoscopic extraperitoneal radical prostatectomy,” J. Endourol. 22, 22952298 (2008).
133. V. E. de Meijer, C. Verhoef, J. W. Kuiper, I. P. Alwayn, G. Kazemier, and J. N. Ijzermans, “Radiofrequency ablation in patients with primary and secondary hepatic malignancies,” J. Gastrointest. Surg. 10, 960973 (2006).
134. G. T. Haar, D. Sinnett, and I. Rivens, “High intensity focused ultrasound–a surgical technique for the treatment of discrete liver tumours,” Phys. Med. Biol. 34, 17431750 (1989).
135. W. E. Moore, R. M. Lopez, D. E. Matthews, P. W. Sheets, M. R. Etchison, A. S. Hurwitz, A. A. Chalian, F. J. Fry, D. W. Vane, and J. L. Grosfeld, “Evaluation of high-intensity therapeutic ultrasound irradiation in the treatment of experimental hepatoma,” J. Pediatr. Surg. 24, 3033 (1989).
136. R. Yang, C. R. Reilly, F. J. Rescorla, P. R. Faught, N. T. Sanghvi, F. J. Fry, T. D. Franklin Jr., L. Lumeng, and J. L. Grosfeld, “High-intensity focused ultrasound in the treatment of experimental liver cancer,” Arch. Surg. 126, 10021009 (1991).
137. R. Yang, N. T. Sanghvi, F. J. Rescorla, C. A. Galliani, F. J. Fry, S. L. Griffith, and J. L. Grosfeld, “Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound,” Invest. Radiol. 27, 796803 (1992).
138. L. Chen, I. Rivens, G. ter Haar, S. Riddler, C. R. Hill, and J. P. Bensted, “Histological changes in rat liver tumours treated with high-intensity focused ultrasound,” Ultrasound Med. Biol. 19, 6774 (1993).
139. J. E. Kennedy, F. Wu, G. R. ter Haar, F. V. Gleeson, R. R. Phillips, M. R. Middleton, and D. Cranston, “High-intensity focused ultrasound for the treatment of liver tumours,” Ultrasonics 42, 931935 (2004).
140. C. X. Li, G. L. Xu, Z. Y. Jiang, J. J. Li, G. Y. Luo, H. B. Shan, R. Zhang, and Y. Li, “Analysis of clinical effect of high-intensity focused ultrasound on liver cancer,” World J. Gastroenterol. 10, 22012204 (2004).
141. T. A. Leslie, J. E. Kennedy, R. O. Illing, G. R. Ter Haar, F. Wu, R. R. Phillips, P. J. Friend, I. S. Roberts, D. W. Cranston, and M. R. Middleton, “High-intensity focused ultrasound ablation of liver tumours: Can radiological assessment predict the histological response?,” Br. J. Radiol. 81, 564571 (2008).
142. E. A. Stewart, W. M. Gedroyc, C. M. Tempany, B. J. Quade, Y. Inbar, T. Ehrenstein, A. Shushan, J. T. Hindley, R. D. Goldin, M. David, M. Sklair, and J. Rabinovici, “Focused ultrasound treatment of uterine fibroid tumors: Safety and feasibility of a noninvasive thermoablative technique,” Am. J. Obstet. Gynecol. 189, 4854 (2003).
143. B. Quesson, M. Merle, M. O. Kohler, C. Mougenot, S. Roujol, B. D. de Senneville, and C. T. Moonen, “A method for MRI guidance of intercostal high intensity focused ultrasound ablation in the liver,” Med. Phys. 37, 25332540 (2010).
144. D. Jeanmonod, M. Magnin, and A. Morel, “Chronic neurogenic pain and the medial thalamotomy,” Schweiz Rundsch Med. Prax 83, 702707 (1994).
145. L. Steiner, D. Forster, L. Leksell, B. A. Meyerson, and J. Boethius, “Gammathalamotomy in intractable pain,” Acta Neurochir. Suppl. (Wien) 52, 173184 (1980).
146. D. Jeanmonod, B. Werner, A. Morel, L. Michels, E. Zadicario, G. Schiff, and E. Martin, “Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain,” Neurosurg. Focus 32, E1 (2012).
147. E. Martin, D. Jeanmonod, A. Morel, E. Zadicario, and B. Werner, “High-intensity focused ultrasound for noninvasive functional neurosurgery,” Ann. Neurol. 66, 858861 (2009).
148. J. Elias, D. Huss, M. Khaled, S. Monteith, and R. Frysinger, paper presented at the a new paradigm for noninvasive lesioning and neuromodulation. Congress of Neurological Surgeons 2011 Annual Meeting Abstract, 2011 (unpublished).
149. J. A. Boockvar, A. Telfeian, G. H. Baltuch, B. Skolnick, T. Simuni, M. Stern, M. L. Schmidt, and J. Q. Trojanowski, “Long-term deep brain stimulation in a patient with essential tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report,” J. Neurosurg. 93, 140144 (2000).
150. S. Deiner and J. Hagen, “Parkinson's disease and deep brain stimulator placement,” Anesthesiol. Clin. 27, 391415 (2009).
151. D. K. Binder, G. M. Rau, and P. A. Starr, “Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders,” Neurosurgery 56, 722732 (2005).
152. D. Kondziolka, D. Whiting, A. Germanwala, and M. Oh, “Hardware-related complications after placement of thalamic deep brain stimulator systems,” Stereotact. Funct. Neurosurg. 79, 228233 (2002).
153. K. A. Sillay, P. S. Larson, and P. A. Starr, “Deep brain stimulator hardware-related infections: incidence and management in a large series,” Neurosurgery 62, 360366366367 (2008).
154. J. M. Schwalb, H. A. Riina, B. Skolnick, J. L. Jaggi, T. Simuni, and G. H. Baltuch, “Revision of deep brain stimulator for tremor. Technical note,” J. Neurosurg. 94, 10101012 (2001).
155. S. Dromi, V. Frenkel, A. Luk, B. Traughber, M. Angstadt, M. Bur, J. Poff, J. Xie, S. K. Libutti, K. C. Li, and B. J. Wood, “Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect,” Clin. Cancer Res. 13, 27222727 (2007).
156. J. A. Tashjian, M. W. Dewhirst, D. Needham, and B. L. Viglianti, “Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques,” Int. J. Hyperthermia 24, 7990 (2008).
157. A. M. Ponce, Z. Vujaskovic, F. Yuan, D. Needham, and M. W. Dewhirst, “Hyperthermia mediated liposomal drug delivery,” Int. J. Hyperthermia 22, 205213 (2006).
158. K. Kooiman, M. Emmer, M. Foppen-Harteveld, A. van Wamel, and N. de Jong, “Increasing the endothelial layer permeability through ultrasound-activated microbubbles,” IEEE Trans. Biomed. Eng. 57, 2932 (2010).
159. R. Seip, C. T. Chin, C. S. Hall, B. I. Raju, A. Ghanem, and K. Tiemann, “Targeted ultrasound-mediated delivery of nanoparticles: On the development of a new HIFU-based therapy and imaging device,” IEEE Trans. Biomed. Eng. 57, 6170 (2010).
160. P. A. Dayton, S. Zhao, S. H. Bloch, P. Schumann, K. Penrose, T. O. Matsunaga, R. Zutshi, A. Doinikov, and K. W. Ferrara, “Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy,” Mol. Imaging. 5, 160174 (2006).
161. D. Needham and M. W. Dewhirst, “The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors,” Adv. Drug. Deliv. Rev. 53, 285305 (2001).
162. M. Kinoshita, N. McDannold, F. A. Jolesz, and K. Hynynen, “Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption,” Proc. Natl. Acad. Sci. U.S.A. 103, 1171911723 (2006).
163. A. L. Klibanov, “Preparation of targeted microbubbles: Ultrasound contrast agents for molecular imaging,” Med. Biol. Eng. Comput. 47, 875882 (2009).
164. J. R. Eisenbrey, M. C. Soulen, and M. A. Wheatley, “Delivery of encapsulated Doxorubicin by ultrasound-mediated size reduction of drug-loaded polymer contrast agents,” IEEE Trans. Biomed. Eng. 57, 2428 (2010).
165. A. L. Klibanov, T. I. Shevchenko, B. I. Raju, R. Seip, and C. T. Chin, “Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: A tool for targeted drug delivery,” J. Controlled Release 148, 1317 (2010).
166. A. R. Jayaweera, N. Edwards, W. P. Glasheen, F. S. Villanueva, R. D. Abbott, and S. Kaul, “In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells,” Circ. Res. 74, 11571165 (1994).
167. A. V. Patil, J. J. Rychak, A. L. Klibanov, and J. A. Hossack, “Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: In vitro and ex vivo results,” Mol. Imaging 10, 238247 (2011).
168. N. J. Abbott and I. A. Romero, “Transporting therapeutics across the blood-brain barrier,” Mol. Med. Today 2, 106113 (1996).
169. A. Misra, S. Ganesh, A. Shahiwala, and S. P. Shah, “Drug delivery to the central nervous system: A review,” J. Pharm. Pharm. Sci. 6, 252273 (2003).
170. J. T. Patrick, M. N. Nolting, S. A. Goss, K. A. Dines, J. L. Clendenon, M. A. Rea, and R. F. Heimburger, “Ultrasound and the blood-brain barrier,” Adv. Exp. Med. Biol. 267, 369381 (1990).
171. K. Hynynen, N. McDannold, N. Vykhodtseva, and F. A. Jolesz, “Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits,” Radiology 220, 640646 (2001).
172. G. Trubestein, C. Engel, F. Etzel, A. Sobbe, H. Cremer, and U. Stumpff, “Thrombolysis by ultrasound,” Clin. Sci. Mol. Med. Suppl. 3, 697s698s (1976).
173. R. Medel, R. W. Crowley, M. S. McKisic, A. S. Dumont, and N. F. Kassell, “Sonothrombolysis: An emerging modality for the management of stroke,” Neurosurgery 65, 979993 (2009).
174. A. V. Alexandrov, A. W. Wojner, and J. C. Grotta, “CLOTBUST: Design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke,” J. Neuroimaging 14, 108112 (2004).
175. A. V. Alexandrov, C. A. Molina, J. C. Grotta, Z. Garami, S. R. Ford, J. Alvarez-Sabin, J. Montaner, M. Saqqur, A. M. Demchuk, L. A. Moye, M. D. Hill, and A. W. Wojner, “Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke,” N. Engl. J. Med. 351, 21702178 (2004).
176.Prevalence of disabilities and associated health conditions among adults–United States, 1999,” MMWR Morb Mortal Wkly Rep 50, 120125 (2001).
177. W. Rosamond, K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, S. M. Hailpern, M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lloyd-Jones, M. McDermott, J. Meigs, C. Moy, G. Nichol, C. O’Donnell, V. Roger, P. Sorlie, J. Steinberger, T. Thom, M. Wilson, and Y. Hong, “Heart disease and stroke statistics–2008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee,” Circulation 117, e25e146 (2008).
178. P. W. Madsen Jr. and J. W. Gersten, “The effect of ultrasound on conduction velocity of peripheral nerve,” Arch. Phys. Med. Rehabil. 42, 645649 (1961).
179. R. R. Young and E. Henneman, “Reversible block of nerve conduction by ultrasound,” Arch. Neurol. 4, 8389 (1961).
180. J. L. Foley, J. W. Little, F. L. Starr III, C. Frantz, and S. Vaezy, “Image-guided HIFU neurolysis of peripheral nerves to treat spasticity and pain,” Ultrasound Med. Biol. 30, 11991207 (2004).
181. J. L. Foley, J. W. Little, and S. Vaezy, “Image-guided high-intensity focused ultrasound for conduction block of peripheral nerves,” Ann. Biomed. Eng. 35, 109119 (2007).
182. J. Van Zundert, P. Vanelderen, A. Kessels, and M. van Kleef, “Radiofrequency treatment of facet-related pain: Evidence and controversies,” Curr. Pain Headache Rep. 16, 1925 (2012).
183. H. H. Kampinga and E. Dikomey, “Hyperthermic radiosensitization: Mode of action and clinical relevance,” Int. J. Radiat. Biol. 77, 399408 (2001).
184. O. S. Nielsen, “Effect of fractionated hyperthermia on hypoxic cells in vitro,” Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 39, 7382 (1981).
185. G. Arcangeli, C. Nervi, A. Cividalli, and G. A. Lovisolo, “Problem of sequence and fractionation in the clinical application of combined heat and radiation,” Cancer Res. 44, 4857s4863s (1984).
186. A. Jernberg, M. R. Edgren, R. Lewensohn, H. Wiksell, and A. Brahme, “Cellular effects of high-intensity focused continuous wave ultrasound alone and in combination with x-rays,” Int. J. Radiat. Biol. 77, 127135 (2001).
187. C. T. Moonen, “Spatio-temporal control of gene expression and cancer treatment using magnetic resonance imaging-guided focused ultrasound,” Clin. Cancer Res. 13, 34823489 (2007).
188. D. P. Madio, P. van Gelderen, D. DesPres, A. W. Olson, J. A. de Zwart, T. W. Fawcett, N. J. Holbrook, M. Mandel, and C. T. Moonen, “On the feasibility of MRI-guided focused ultrasound for local induction of gene expression,” J. Magn. Reson. Imaging 8, 101104 (1998).
189. R. Bekeredjian, P. A. Grayburn, and R. V. Shohet, “Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine,” J. Am. Coll. Cardiol. 45, 329335 (2005).
190. R. Bekeredjian, S. Behrens, J. Ruef, E. Dinjus, E. Unger, M. Baum, and H. F. Kuecherer, “Potential of gold-bound microtubules as a new ultrasound contrast agent,” Ultrasound Med. Biol. 28, 691695 (2002).
191. A. A. Rahim, S. L. Taylor, N. L. Bush, G. R. ter Haar, J. C. Bamber, and C. D. Porter, “Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasound,” J. Gene Med. 8, 13471357 (2006).
192. P. E. Huber, M. J. Mann, L. G. Melo, A. Ehsan, D. Kong, L. Zhang, M. Rezvani, P. Peschke, F. Jolesz, V. J. Dzau, and K. Hynynen, “Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery,” Gene Ther. 10, 16001607 (2003).
193. Y. Liu, T. Kon, C. Li, and P. Zhong, “High intensity focused ultrasound-induced gene activation in sublethally injured tumor cells in vitro,” J. Acoust. Soc. Am 118, 33283336 (2005).
194. Y. Liu, T. Kon, C. Li, and P. Zhong, “High intensity focused ultrasound-induced gene activation in solid tumors,” J. Acoust. Soc. Am. 120, 492501 (2006).
195. L. C. Phillips, A. L. Klibanov, B. R. Wamhoff, and J. A. Hossack, “Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery,” Ultrasound Med. Biol. 36, 14701480 (2010).
196. C. Plathow, F. Lohr, G. Divkovic, G. Rademaker, N. Farhan, P. Peschke, I. Zuna, J. Debus, C. D. Claussen, H. U. Kauczor, C. Y. Li, J. Jenne, and P. Huber, “Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results,” Invest. Radiol. 40, 729735 (2005).
197. J. L. Tlaxca, J. J. Rychak, P. B. Ernst, P. R. Konkalmatt, T. I. Shevchenko, T. T. Pizzaro, J. Rivera-Nieves, A. L. Klibanov, and M. B. Lawrence, “Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease,” J. Controlled Release 165, 216225 (2013).
198. D. J. Engel, R. Muratore, K. Hirata, R. Otsuka, K. Fujikura, K. Sugioka, C. Marboe, F. L. Lizzi, and S. Homma, “Myocardial lesion formation using high-intensity focused ultrasound,” J. Am. Soc. Echocardiogr. 19, 932937 (2006).
199. A. Metzner, K. R. Chun, K. Neven, A. Fuernkranz, F. Ouyang, M. Antz, R. Tilz, T. Zerm, B. Koektuerk, E. Wissner, I. Koester, S. Ernst, S. Boczor, K. H. Kuck, and B. Schmidt, “Long-term clinical outcome following pulmonary vein isolation with high-intensity focused ultrasound balloon catheters in patients with paroxysmal atrial fibrillation,” Europace 12, 188193 (2010).
200. F. J. Fry, H. W. Ades, and W. J. Fry, “Production of reversible changes in the central nervous system by ultrasound,” Science 127, 8384 (1958).
201. P. C. Rinaldi, J. P. Jones, F. Reines, and L. R. Price, “Modification by focused ultrasound pulses of electrically evoked responses from an in vitro hippocampal preparation,” Brain Res. 558, 3642 (1991).
202. W. J. Tyler, Y. Tufail, M. Finsterwald, M. L. Tauchmann, E. J. Olson, and C. Majestic, “Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound,” PLoS One 3, e3511 (2008).
203. Y. Tufail, A. Yoshihiro, S. Pati, M. M. Li, and W. J. Tyler, “Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound,” Nat. Protoc. 6, 14531470 (2011).
204. M. O. Kohler, C. Mougenot, B. Quesson, J. Enholm, B. Le Bail, C. Laurent, C. T. Moonen, and G. J. Ehnholm, “Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry,” Med. Phys. 36, 35213535 (2009).
205. R. Agarwal, M. Bergey, S. Sonnad, H. Butowsky, M. Bhargavan, and M. H. Bleshman, “Inpatient CT and MRI utilization: Trends in the academic hospital setting,” J. Am. Coll. Radiol. 7, 949955 (2010).
206. Y. Korogi and M. Takahashi, “Cost containment and diffusion of MRI: oil and water?. Japanese experience,” Eur. Radiol. 7(5), 256258 (1997).
207. W. R. Hendee and E. R. Ritenour, Medical Imaging Physics, 4th ed. (Wiley-Liss, New York, 2002).
208. J. F. Aubry, M. Tanter, M. Pernot, J. L. Thomas, and M. Fink, “Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans,” J. Acoust. Soc. Am. 113, 8493 (2003).
209. K. Hynynen and D. DeYoung, “Temperature elevation at muscle-bone interface during scanned, focused ultrasound hyperthermia,” Int. J. Hyperthermia 4, 267279 (1988).
210. C. W. Connor and K. Hynynen, “Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery,” IEEE Trans. Biomed. Eng. 51, 16931706 (2004).
211. N. B. Smith, J. M. Temkin, F. Shapiro, and K. Hynynen, “Thermal effects of focused ultrasound energy on bone tissue,” Ultrasound Med. Biol. 27, 14271433 (2001).
212. J. F. Lehmann, G. D. Brunne, A. J. Martinis, and J. A. McMillan, “Ultrasonic effects as demonstrated in live pigs with surgical metallic implants,” Arch. Phys. Med. Rehabil. 40, 483488 (1959).
213. S. W. Yoon, C. Lee, S. H. Cha, J. S. Yu, Y. J. Na, K. A. Kim, S. G. Jung, and S. J. Kim, “Patient selection guidelines in MR-guided focused ultrasound surgery of uterine fibroids: A pictorial guide to relevant findings in screening pelvic MRI,” Eur. Radiol. 18, 29973006 (2008).
214. J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynyen, N. McDannold, Y. Inbar, Y. Itzchak, J. Rabinovici, H. S. Kim, J. F. Geschwind, G. Hesley, B. Gostout, T. Ehrenstein, S. Hengst, M. Sklair-Levy, A. Shushan, and F. Jolesz, “MRI guidance of focused ultrasound therapy of uterine fibroids: Early results,” AJR Am. J. Roentgenol. 183, 17131719 (2004).
215. H. L. Liu, N. McDannold, and K. Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Med. Phys. 32, 12701280 (2005).
216. H. L. Liu, C. L. Hsu, S. M. Huang, and Y. W. Hsi, “Focal beam distortion and treatment planning for transrib focused ultrasound thermal therapy: A feasibility study using a two-dimensional ultrasound phased array,” Med. Phys. 37, 848860 (2010).
217. M. Tanter, M. Pernot, J.-F. Aubry, G. Montaldo, F. Marquet, and M. Fink, “Compensating for bone interfaces and respiratory motion in high-intensity focused ultrasound,” Int. J. Hyperthermia 23, 141151 (2007).
218. Y. Yao and E. S. Ebbini, “Refocusing dual-mode ultrasound arrays in the presence of strongly scattering obstacles,” IEEE Ultrasonics Symposium, 239242 (2004).
219. L. Zhang, W. Z. Chen, Y. J. Liu, X. Hu, K. Zhou, L. Chen, S. Peng, H. Zhu, H. L. Zou, J. Bai, and Z. B. Wang, “Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus,” Eur. J. Radiol. 73, 396403 (2010).
220. X. Fan and K. Hynynen, “Ultrasound surgery using multiple sonications–treatment time considerations,” Ultrasound Med. Biol. 22, 471482 (1996).
221. D. R. Daum and K. Hynynen, “Thermal dose optimization via temporal switching in ultrasound surgery,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 45, 208215 (1998).
222. J. K. Enholm, M. O. Kohler, B. Quesson, C. Mougenot, C. T. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57, 103113 (2010).
223. D. Melodelima, W. A. N’Djin, H. Parmentier, M. Rivoire, and J. Y. Chapelon, “Toric HIFU transducer for large thermal ablation,” Conf. Proc. IEEE Eng. Med. Biol. Soc. 2007, 230233 (2007).
224. V. Zderic, J. Foley, W. Luo, and S. Vaezy, “Prevention of post-focal thermal damage by formation of bubbles at the focus during high intensity focused ultrasound therapy,” Med. Phys. 35, 42924299 (2008).
225. R. L. Clarke and G. R. ter Haar, “Temperature rise recorded during lesion formation by high-intensity focused ultrasound,” Ultrasound Med. Biol. 23, 299306 (1997).
226. N. A. Watkin, G. R. ter Haar, and I. Rivens, “The intensity dependence of the site of maximal energy deposition in focused ultrasound surgery,” Ultrasound Med. Biol. 22, 483491 (1996).
227. R. G. Holt and R. A. Roy, “Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material,” Ultrasound Med. Biol. 27, 13991412 (2001).
228. N. J. McDannold, N. I. Vykhodtseva, and K. Hynynen, “Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits,” Radiology 241, 95106 (2006).
229. D. Kopelman, Y. Inbar, A. Hanannel, D. Freundlich, S. Vitek, R. Schmidt, A. Sokolov, O. A. Hatoum, and J. Rabinovici, “Magnetic resonance-guided focused ultrasound surgery using an enhanced sonication technique in a pig muscle model,” Eur. J. Radiol. 59, 190197 (2006).
230. P. R. Stauffer, C. J. Diederich, and M. H. Seegenschmiedt, “Interstitial heating technologies,” in Principles and Practices of Thermoradiotherapy and Thermochemotherapy, edited by M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon (Springer-Verlag, Berlin, 1995).
231. C. Lafon, D. Melodelima, R. Salomir, and J. Y. Chapelon, “Interstitial devices for minimally invasive thermal ablation by high-intensity ultrasound,” Int. J. Hyperthermia 23, 153163 (2007).
232. C. Lafon, J. Y. Chapelon, F. Prat, F. Gorry, J. Margonari, Y. Theillere, and D. Cathignol, “Design and preliminary results of an ultrasound applicator for interstitial thermal coagulation,” Ultrasound Med. Biol. 24, 113122 (1998).
233. C. Lafon, L. de, Y. Theillere, F. Prat, J. Y. Chapelon, and D. Cathignol, “Optimizing the shape of ultrasound transducers for interstitial thermal ablation,” Med. Phys. 29, 290297 (2002).
234. T. D. Mast, P. G. Barthe, I. R. Makin, M. H. Slayton, C. P. Karunakaran, M. T. Burgess, A. Alqadah, and S. M. Rudich, “Treatment of rabbit liver cancer in vivo using miniaturized image-ablate ultrasound arrays,” Ultrasound Med. Biol. 37, 16091621 (2011).
235. I. R. Makin, T. D. Mast, W. Faidi, M. M. Runk, P. G. Barthe, and M. H. Slayton, “Miniaturized ultrasound arrays for interstitial ablation and imaging,” Ultrasound Med. Biol. 31, 15391550 (2005).
236. N. R. Owen, J. Y. Chapelon, G. Bouchoux, R. Berriet, G. Fleury, and C. Lafon, “Dual-mode transducers for ultrasound imaging and thermal therapy,” Ultrasonics 50, 216220 (2010).
237. D. Melodelima, F. Prat, J. Fritsch, Y. Theillere, and D. Cathignol, “Treatment of esophageal tumors using high intensity intraluminal ultrasound: First clinical results,” J. Trans. Med. 6, 28 (2008).
238. D. Melodelima, R. Salomir, J. Y. Chapelon, Y. Theillere, C. Moonen, and D. Cathignol, “Intraluminal high intensity ultrasound treatment in the esophagus under fast MR temperature mapping: in vivo studies,” Magn. Reson. Med. 54, 975982 (2005).
239. A. B. Ross, C. J. Diederich, W. H. Nau, H. Gill, D. M. Bouley, B. Daniel, V. Rieke, K. Butts, and G. Sommer, “Highly directional transurethral ultrasound applicators with rotational control for MRI guided prostatic thermal therapy,” Phys. Med. Biol. 49, 189204 (2004).
240. R. Chopra, N. Baker, V. Choy, A. Boyes, K. Tang, D. Bradwell, and M. J. Bronskill, “MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control,” Med. Phys. 35, 13461357 (2008).
241. R. Chopra, M. Burtnyk, W. A. N’Djin, and M. Bronskill, “MRI-controlled transurethral ultrasound therapy for localised prostate cancer,” Int. J. Hyperthermia 26, 804821 (2010).
242. A. B. Ross, C. J. Diederich, W. H. Nau, V. Rieke, R. K. Butts, G. Sommer, H. Gill, and D. M. Bouley, “Curvilinear transurethral ultrasound applicator for selective prostate thermal therapy,” Med. Phys. 32, 15551565 (2005).
243. A. M. Kinsey, C. J. Diederich, V. Rieke, W. H. Nau, K. B. Pauly, D. Bouley, and G. Sommer, “Transurethral ultrasound applicators with dynamic multi-sector control for prostate thermal therapy: In vivo evaluation under MR guidance,” Med. Phys. 35, 20812093 (2008).
244. K. B. Pauly, C. J. Diederich, V. Rieke, D. Bouley, J. Chen, W. H. Nau, A. B. Ross, A. M. Kinsey, and G. Sommer, “Magnetic resonance-guided high-intensity ultrasound ablation of the prostate,” Top. Magn. Reson. Imaging 17, 195207 (2006).
245. R. Chopra, C. Luginbuhl, F. S. Foster, and M. J. Bronskill, “Multifrequency ultrasound transducers for conformal interstitial thermal therapy,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50, 881889 (2003).
246. K. Siddiqui, R. Chopra, S. Vedula, L. Sugar, M. Haider, A. Boyes, M. Musquera, M. Bronskill, and L. Klotz, “MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies,” Urology 76, 15061511 (2010).
247. H. Fosmire, K. Hynynen, G. W. Drach, B. Stea, P. Swift, and J. R. Cassady, “Feasibility and toxicity of transrectal ultrasound hyperthermia in the treatment of locally advanced adenocarcinoma of the prostate,” Int. J. Radiat. Oncol., Biol., Phys 26, 253259 (1993).
248. M. D. Hurwitz, J. L. Hansen, S. Prokopios-Davos, J. Manola, Q. Wang, B. A. Bornstein, K. Hynynen, and I. D. Kaplan, “Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153,” Cancer 117, 510516 (2011).
249. N. B. Smith, N. K. Merrilees, M. Dahleh, and K. Hynynen, “Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease,” Int. J. Hyperthermia 17, 271282 (2001).
250. J. H. Wootton, I. C. Hsu, and C. J. Diederich, “Endocervical ultrasound applicator for integrated hyperthermia and HDR brachytherapy in the treatment of locally advanced cervical carcinoma,” Med. Phys. 38, 598 (2011).
251. T. Juang, J. Wootton, I. C. Hsu, and C. Diederich, “Treatment delivery platform for conformal catheter-based ultrasound hyperthermia,” Proc. SPIE 7181, 718109 (2009).
252. W. H. Nau, C. J. Diederich, and E. C. Burdette, “Evaluation of multielement catheter-cooled interstitial ultrasound applicators for high-temperature thermal therapy,” Med. Phys. (USA) 28, 15251534 (2001).
253. M. Kangasniemi, C. J. Diederich, R. E. Price, R. J. Stafford, D. F. Schomer, L. E. Olsson, P. D. Tyreus, W. H. Nau, and J. D. Hazle, “Multiplanar MR temperature-sensitive imaging of cerebral thermal treatment using interstitial ultrasound applicators in a canine model,” J. Magn. Reson. Imaging 16, 522531. (2002).
254. W. H. Nau, C. J. Diederich, A. B. Ross, K. Butts, V. Rieke, D. M. Bouley, H. Gill, B. Daniel, and G. Sommer, “MRI-guided interstitial ultrasound thermal therapy of the prostate: A feasibility study in the canine model,” Med. Phys. 32, 733743 (2005).
255. E. G. Moros, R. B. Roemer, and K. Hynynen, “Pre-focal plane high-temperature regions induced by scanning focused ultrasound beams,” Int. J. Hyperthermia 6, 351366 (1990).
256. P. J. Keall, G. S. Mageras, J. M. Balter, R. S. Emery, K. M. Forster, S. B. Jiang, J. M. Kapatoes, D. A. Low, M. J. Murphy, B. R. Murray, C. R. Ramsey, M. B. Van Herk, S. S. Vedam, J. W. Wong, and E. Yorke, “The management of respiratory motion in radiation oncology report of AAPM Task Group 76,” Med. Phys. 33, 38743900 (2006).
257. W. A. Grissom, V. Rieke, A. B. Holbrook, Y. Medan, M. Lustig, J. Santos, M. V. McConnell, and K. B. Pauly, “Hybrid referenceless and multibaseline subtraction MR thermometry for monitoring thermal therapies in moving organs,” Med. Phys. 37, 50145026 (2010).
258. S. H. Benedict, K. M. Yenice, D. Followill, J. M. Galvin, W. Hinson, B. Kavanagh, P. Keall, M. Lovelock, S. Meeks, L. Papiez, T. Purdie, R. Sadagopan, M. C. Schell, B. Salter, D. J. Schlesinger, A. S. Shiu, T. Solberg, D. Y. Song, V. Stieber, R. Timmerman, W. A. Tome, D. Verellen, L. Wang, and F. F. Yin, “Stereotactic body radiation therapy: The report of AAPM Task Group 101,” Med. Phys. 37, 40784101 (2010).
259. L. InSightec, ExAblate 2000 MR Guided Focused Ultrasound Surgery Operator's Manual, Rev 04/08 ed. (InSightec, Ltd., Tirat Carmel, 2008).
260. R. Salomir, J. Palussiere, F. C. Vimeux, J. A. de Zwart, B. Quesson, M. Gauchet, P. Lelong, J. Pergrale, N. Grenier, and C. T. Moonen, “Local hyperthermia with MR-guided focused ultrasound: spiral trajectory of the focal point optimized for temperature uniformity in the target region,” J. Magn. Reson. Imaging 12, 571583 (2000).<571::AID-JMRI9>3.0.CO;2-2
261. P. J. White, G. T. Clement, and K. Hynynen, “Longitudinal and shear mode ultrasound propagation in human skull bone,” Ultrasound Med. Biol. 32, 10851096 (2006).
262. G. T. Clement and K. Hynynen, “A non-invasive method for focusing ultrasound through the human skull,” Phys. Med. Biol. 47, 12191236 (2002).
263. R. J. McGough, M. L. Kessler, E. S. Ebbini, and C. A. Cain, “Treatment planning for hyperthermia with ultrasound phased arrays,” IEEE Trans. Ultrason. Ferroelectr. 43, 10741084 (1996).
264. K. Hynynen, “The role of nonlinear ultrasound propagation during hyperthermia treatments,” Med. Phys. 18, 11561163 (1991).
265. A. Pulkkinen and K. Hynynen, “Computational aspects in high intensity ultrasonic surgery planning,” Comput. Med. Imaging Graph. 34, 6978 (2010).
266. M. D. Harpen, “Basic nonlinear acoustics: An introduction for radiological physicists,” Med. Phys. 33, 32413247 (2006).
267. K. Kuroda, D. Kokuryo, E. Kumamoto, K. Suzuki, Y. Matsuoka, and B. Keserci, “Optimization of self-reference thermometry using complex field estimation,” Magn. Reson. Med. 56, 835843 (2006).
268. V. Rieke, K. K. Vigen, G. Sommer, B. L. Daniel, J. M. Pauly, and K. Butts, “Referenceless PRF shift thermometry,” Magn. Reson. Med. 51, 12231231 (2004).
269. V. Rieke, A. M. Kinsey, A. B. Ross, W. H. Nau, C. J. Diederich, G. Sommer, and K. B. Pauly, “Referenceless MR thermometry for monitoring thermal ablation in the prostate,” IEEE Trans. Med. Imaging 26, 813821 (2007).
270. B. D. de Senneville, C. Mougenot, and C. T. Moonen, “Real-time adaptive methods for treatment of mobile organs by MRI-controlled high-intensity focused ultrasound,” Magn. Reson. Med. 57, 319330 (2007).
271. K. K. Vigen, B. L. Daniel, J. M. Pauly, and K. Butts, “Triggered, navigated, multi-baseline method for proton resonance frequency temperature mapping with respiratory motion,” Magn. Reson. Med. 50, 10031010 (2003).
272. M. Ries, B. D. de Senneville, S. Roujol, Y. Berber, B. Quesson, and C. Moonen, “Real-time 3D target tracking in MRI guided focused ultrasound ablations in moving tissues,” Magn. Reson. Med. 64, 17041712 (2010).
273. K. Nehrke, P. Bornert, J. Groen, J. Smink, and J. C. Bock, “On the performance and accuracy of 2D navigator pulses,” Magn. Reson. Imaging 17, 11731181 (1999).
274. D. B. Plewes, I. Betty, S. N. Urchuk, and I. Soutar, “Visualizing tissue compliance with MR imaging,” J. Magn. Reson. Imaging 5, 733738 (1995).
275. W. F. Walker, F. J. Fernandez, and L. A. Negron, “A method of imaging viscoelastic parameters with acoustic radiation force,” Phys. Med. Biol. 45, 14371447 (2000).
276. N. McDannold and S. E. Maier, “Magnetic resonance acoustic radiation force imaging,” Med. Phys. 35, 37483758 (2008).
277. M. Radicke, A. Engelbertz, B. Habenstein, M. Lewerenz, O. Oehms, P. Trautner, B. Weber, S. Wrede, and K. Maier, “New image contrast method in magnetic resonance imaging via ultrasound,” Hyperfine Interact. 181, 2126 (2008).
278. E. E. Konofagou and K. Hynynen, “Localized harmonic motion imaging: Theory, simulations and experiments,” Ultrasound Med. Biol. 29, 14051413 (2003).
279. L. Curiel and K. Hynynen, “Localized harmonic motion imaging for focused ultrasound surgery targeting,” Ultrasound Med. Biol. 37, 12301239 (2011).
280. C. Maleke and E. E. Konofagou, “Harmonic motion imaging for focused ultrasound (HMIFU): A fully integrated technique for sonication and monitoring of thermal ablation in tissues,” Phys. Med. Biol. 53, 17731793 (2008).
281. J. Du, G. Hamilton, A. Takahashi, M. Bydder, and C. B. Chung, “Ultrashort echo time spectroscopic imaging (UTESI) of cortical bone,” Magn. Reson. Med. 58, 10011009 (2007).
282. M. F. McNitt-Gray, “AAPM/RSNA physics tutorial for residents: Topics in CT. Radiation dose in CT,” Radiographics 22, 15411553 (2002).
283. P. D. Gatehouse and G. M. Bydder, “Magnetic resonance imaging of short T2 components in tissue,” Clin. Radiol. 58, 119 (2003).
284. I. L. Reichert, M. D. Robson, P. D. Gatehouse, T. He, K. E. Chappell, J. Holmes, S. Girgis, and G. M. Bydder, “Magnetic resonance imaging of cortical bone with ultrashort TE pulse sequences,” Magn. Reson. Imaging. 23, 611618 (2005).
285. M. D. Robson and G. M. Bydder, “Clinical ultrashort echo time imaging of bone and other connective tissues,” NMR Biomed. 19, 765780 (2006).
286. J. Du, M. Carl, M. Bydder, A. Takahashi, C. B. Chung, and G. M. Bydder, “Qualitative and quantitative ultrashort echo time (UTE) imaging of cortical bone,” J. Magn. Reson. 207, 304311 (2010).
287. W. C. Bae, P. C. Chen, C. B. Chung, K. Masuda, D. D’Lima, and J. Du, “Quantitative ultrashort echo time (UTE) MRI of human cortical bone: Correlation with porosity and biomechanical properties,” J. Bone Miner. Res. 27, 848857 (2012).
288. D. Arora, D. Cooley, T. Perry, J. Guo, A. Richardson, J. Moellmer, R. Hadley, D. Parker, M. Skliar, and R. B. Roemer, “MR thermometry-based feedback control of efficacy and safety in minimum-time thermal therapies: Phantom and in-vivo evaluations,” Int. J. Hyperthermia 22, 2942 (2006).
289. D. Arora, M. A. Minor, M. Skliar, and R. B. Roemer, “Control of thermal therapies with moving power deposition field,” Phys. Med. Biol. 51, 12011219 (2006).
290. A. Dhiraj, C. Daniel, P. Trent, S. Mikhail, and B. R. Robert, “Direct thermal dose control of constrained focused ultrasound treatments: phantom and in vivo evaluation,” Phys. Med. Biol. 50, 19191935 (2005).
291. A. B. Holbrook, P. Ghanouni, J. M. Santos, Y. Medan, and K. Butts Pauly, “In vivo MR acoustic radiation force imaging in the porcine liver,” Med. Phys. 38, 50815089 (2011).

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MR-guided focused ultrasound surgery (MRgFUS) is a quickly developing technology with potential applications across a spectrum of indications traditionally within the domain of radiation oncology. Especially for applications where focal treatment is the preferred technique (for example, radiosurgery), MRgFUS has the potential to be a disruptive technology that could shift traditional patterns of care. While currently cleared in the United States for the noninvasive treatment of uterine fibroids and bone metastases, a wide range of clinical trials are currently underway, and the number of publications describing advances in MRgFUS is increasing. However, for MRgFUS to make the transition from a research curiosity to a clinical standard of care, a variety of challenges, technical, financial, clinical, and practical, must be overcome. This installment of the Vision 20/20 series examines the current status of MRgFUS, focusing on the hurdles the technology faces before it can cross over from a research technique to a standard fixture in the clinic. It then reviews current and near-term technical developments which may overcome these hurdles and allow MRgFUS to break through into clinical practice.


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