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Can nontriggered thoracic CT be used for coronary artery calcium scoring? A phantom study
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10.1118/1.4813904
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    Affiliations:
    1 Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands and Center for Medical Imaging – North East Netherlands, Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    2 Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    3 Department of Radiology, Zaans Medical Center, 1500EE Zaandam, The Netherlands
    4 Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    5 Center for Medical Imaging – North East Netherlands, Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    6 Department of Radiology, University Medical Center Utrecht, University of Utrecht, 3584CX Utrecht, The Netherlands
    7 Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands and Center for Medical Imaging – North East Netherlands, Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    a) Author to whom correspondence should be addressed. Electronic mail: r.vliegenthart@umcg.nl; Telephone: +31 50 361 0251; Fax: +31 50 361 1798.
    Med. Phys. 40, 081915 (2013); http://dx.doi.org/10.1118/1.4813904
/content/aapm/journal/medphys/40/8/10.1118/1.4813904
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/8/10.1118/1.4813904

Figures

Image of FIG. 1.
FIG. 1.

The moving cardiac phantom, comprising (a) a computer controlled motion unit, (b) a water container, (c) a thoracic phantom, (d) a lever, and (e) an artificial coronary artery.

Image of FIG. 2.
FIG. 2.

Position of the artificial coronary artery as a function of time, for velocities of 10, 30, 50, 70, and 90 mm/s. The image acquisition windows of CT-A and CT-B in ECG-triggered acquisition mode are indicated, starting at 370 ms and with a width of 330 and 267 ms, respectively.

Image of FIG. 3.
FIG. 3.

Artificial arteries with calcified lesions of high [800 Hounsfield units (HU)], medium (400 HU), and low density (200 HU) in large, medium, and small size. (a) Schematic drawing of an artificial artery, the black shadows indicated the artificial calcified lesions in the artificial artery, the length, radius, and rotation angles of the artificial calcified lesions are also indicated; (b) photograph of three artificial arteries.

Image of FIG. 4.
FIG. 4.

CT images of the artificial high-density calcifications in (a) the nontriggered thoracic examination (large, medium, and small size of the lesion from top to bottom, and velocity of 0, 10, 30, 50, 70, and 90 mm/s from left to right), and (b) ECG-triggered cardiac examination (large, medium, and small size from top to bottom, and 0, 10, and 30 mm/s from left to right). Window center: 75 HU, window width: 350 HU.

Image of FIG. 5.
FIG. 5.

Cardiac motion susceptibility (CMS) index of eight measurable artificial calcified lesions in nontriggered and ECG-triggered CT examinations.

Image of FIG. 6.
FIG. 6.

Comparison of calcium scores between nontriggered and ECG-triggered CT examinations in eight measurable calcified lesions. The CT density thresholds were from 90 to 160 HU in nontriggered CT. The threshold was 130 HU in ECG-triggered CT as reference. A significant difference was indicated by “*.”

Image of FIG. 7.
FIG. 7.

Grouped plots of the calcium scores of the eight measurable artificial calcified lesions in the nontriggered and ECG-triggered CT examinations. The dotted boxes indicate 95% confidence interval (95% CI) of the calcium scores in ECG-triggered CT examinations.

Tables

Generic image for table
TABLE I.

Physical property of artificial calcified lesions of high, medium, and low density in large, medium, and small size.

Generic image for table
TABLE II.

CT acquisition protocol and image reconstruction parameters.

Generic image for table
TABLE III.

Sensitivity to detect coronary calcifications in non-triggered and ECG-triggered CT with a CT density threshold of 130 Hounsfield units.

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/content/aapm/journal/medphys/40/8/10.1118/1.4813904
2013-07-18
2014-04-20
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Can nontriggered thoracic CT be used for coronary artery calcium scoring? A phantom study
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/40/8/10.1118/1.4813904
10.1118/1.4813904
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