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Impact of dose size in single fraction spatially fractionated (grid) radiotherapy for melanoma
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10.1118/1.4862837
/content/aapm/journal/medphys/41/2/10.1118/1.4862837
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/41/2/10.1118/1.4862837

Figures

Image of FIG. 1.
FIG. 1.

Monte Carlo simulated dose profiles for 6 MV grid therapy at the different depths in a water phantom. (a) In plane and (b) cross plane.

Image of FIG. 2.
FIG. 2.

Differential and cumulative dose volume histograms for a 10 cm tumor (6 cm in height and 10 cm in the major and minor axes) located 3 cm deep and treated with either a single fraction of 20 Gy prescription dose grid therapy or one fraction of 4.2 Gy open field. Both regimens have the same equivalent uniform dose of 4.1 Gy.

Image of FIG. 3.
FIG. 3.

The equivalent uniform doses (EUD) of tumors of different sizes in single fraction grid therapy calculated by the LQ model.

Image of FIG. 4.
FIG. 4.

The equivalent uniform doses (EUD) of tumors of different sizes treated with single fraction open field radiotherapy at different prescription doses.

Image of FIG. 5.
FIG. 5.

Therapeutic ratios (TR) of a 10-cm melanoma tumor irradiated with different doses of single fraction grid therapy calculated by the LQ and MLQ models. The different melanoma and normal tissue cell lines with experimentally determined radioresponse LQ parameters are listed in Table I .

Image of FIG. 6.
FIG. 6.

Therapeutic ratios (TR) of melanoma tumors with different diameters treated with different doses of single fraction grid therapy averaged by all melanoma and normal cell lines.

Tables

Generic image for table
TABLE I.

α and β values for melanomas (Ref. 13 ) and normal tissues (Ref. 17 ).

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/content/aapm/journal/medphys/41/2/10.1118/1.4862837
2014-01-27
2014-04-18
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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Impact of dose size in single fraction spatially fractionated (grid) radiotherapy for melanoma
http://aip.metastore.ingenta.com/content/aapm/journal/medphys/41/2/10.1118/1.4862837
10.1118/1.4862837
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