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29. Meanwhile experiments at LCLS showed high hit-ratios on particles that were clean from contaminants and residues.5 Further, an analytical solution to the number of required diffraction patterns for a 3D reconstruction has also recently been published.7 The results show that a 3D data set with 99% probability of full coverage to 3 Å resolution would require on the order of 103–104 patterns for particles between 10 nm and 70 nm in size. This means that under conditions identical to the experiment by Hantke et al.,5 sample consumption would not exceed 107–108 particles. Nevertheless, any improvement in efficiency would be beneficial.
http://aip.metastore.ingenta.com/content/aca/journal/sdy/2/4/10.1063/1.4918726
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/content/aca/journal/sdy/2/4/10.1063/1.4918726
2015-04-21
2016-12-07

Abstract

Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so far, coherent diffractiveimages have been recorded from biological specimens, aerosols, and quantum systems with a few-tens-of-nanometers resolution. In March 2014, LCLS held a workshop to discuss the scientific and technical challenges for reaching the ultimate goal of atomic resolution with single-shot coherent diffractiveimaging. This paper summarizes the workshop findings and presents the roadmap toward reaching atomic resolution, 3D imaging at free-electron laser sources.

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