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Modification of microneedles using inkjet printing
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Figures

Image of FIG. 1.

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FIG. 1.

Force-displacement data from nanoindentation of Gantrez® AN-139 material.

Image of FIG. 2.

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FIG. 2.

Fourier transform infrared spectrum for Gantrez® AN-139 material.

Image of FIG. 3.

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FIG. 3.

Scanning electron micrographs of unmodified and quantum dot-coated Gantrez® AN-139 microneedles. (a) Scanning electron micrograph of three unmodified Gantrez® AN-139 polymer microneedles in a five microneedle array; these microneedles were produced using visible light dynamic mask micro-stereolithography-micromolding. (b) Scanning electron micrograph of three quantum dot-coated Gantrez® AN-139 polymer microneedles in a five microneedle array; these microneedles were produced using visible light dynamic mask micro-stereolithography-micromolding and piezoelectric inkjet printing. Triangle-shaped regions, which were modified by the quantum dot solution, can be observed on the longitudinally cut surfaces of the coated microneedles.

Image of FIG. 4.

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FIG. 4.

Scanning electron micrographs of an unmodified Gantrez® AN-139 microneedle and a quantum dot-coated Gantrez® AN-139 microneedle. (a) Scanning electron micrograph of an individual unmodified Gantrez® AN-139 polymer microneedle. (b) Scanning electron micrograph of an individual quantum dot-coated Gantrez® AN-139 polymer microneedle. The longitudinally cut surface of the coated microneedle exhibited crater-like features, which were attributed to hydrolysis of the Gantrez® AN-139 polymer by the quantum dot solution. Sodium chloride crystal precipitation from phosphate buffered saline solution was observed on the coated microneedle surface.

Image of FIG. 5.

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FIG. 5.

Maximum projections (in red) rendered from acquired z-stack multiphoton images of quantum dot delivery into porcine skin. (a) Topically applied quantum dots one hour after application. The skin was oriented with the stratum corneum at the top of the imaging window. (b) A single microneedle one hour after application. The image was oriented with the microneedle and the stratum corneum at the bottom of the imaging window. In these figures, the spacing between the bars on the Z-axis is 50 μm. Inversion of the colors was performed to facilitate viewing.

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/content/aip/journal/adva/1/2/10.1063/1.3602461
2011-06-10
2014-04-19

Abstract

In this study, biodegradable acid anhydride copolymer microneedles containing quantum dots were fabricated by means of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing. Nanoindentation was performed to obtain the hardness and the Young's modulus of the biodegradable acid anhydride copolymer. Imaging of quantum dots within porcine skin was accomplished by means of multiphoton microscopy. Our results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a wide range of geometries as well as a wide range of pharmacologic agent compositions.

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Scitation: Modification of microneedles using inkjet printing
http://aip.metastore.ingenta.com/content/aip/journal/adva/1/2/10.1063/1.3602461
10.1063/1.3602461
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