NOTICE: Scitation Maintenance Sunday, March 1, 2015.

Scitation users may experience brief connectivity issues on Sunday, March 1, 2015 between 12:00 AM and 7:00 AM EST due to planned network maintenance.

Thank you for your patience during this process.

banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
The theory of modulated hormone therapy for the treatment of breast cancer in pre- and post-menopausal women
Rent this article for
Access full text Article
1. A. Johnson and J. Shekhdar, Journal of Evaluation in Clinical Practice 11, 21 (2005).
2. J. Mandelblatt, M. Figueiredo, and J. Cullen, Health and Quality of Life Outcomes 1, 45 (2003).
3. S. J. London, J. L. Connolly, S. J. Schnitt, and G. A. Golditz, The Journal of the American Medical Association 267, 941 (1992).
4. E. Anderson, S. C. Reed, R. A. Huseby, and C. P. Oliver, Cancer 3, 410 (1950).<410::AID-CNCR2820030303>3.0.CO;2-H
5. R. B. Wallace, B. M. Sherman, J. A. Bean, J. P. Leeper, and A. E. Treloar, Cancer Research 38, 4021 (1978).
6. H. Fredholm, S. Eaker, J. Frisell, L. Holmberg, I. Fredriksson, and H. Lindman, PLoS ONE 4, e7695 (2009).
7. D. Flesch-Janys, T. Slanger, E. Mutschelknauss, S. Kropp, N. Obi, E. Vettorazzi, W. Braendle, G. Bastert, S. Hentschel, J. Berger, and J. Chang-Claude, International Journal of Cancer 123, 933 (2008).
8. K. Takahashi, M. Ohmichi, M. Yoshida, K. Hisamoto, S. Mabuchi, E. Arimoto-Ishida, A. Mori, A. Tsutsumi, K. Tasaka, Y. Murata, and H. Kurachi, Journal of Endocrinology 178, 319 (2003).
9. P. Kastner, A. Krust, B. Turcotte, U. Stropp, L. Tora, H. Gronemeyer, and P. Chambon, European Molecular Biology Organization Journal 9, 1603 (1990).
10. J. D. Graham and C. L. Clarke, Endocrine Reviews 18, 502 (1997).
11. D. X. Wen, Y.-F. Xu, Dale E. Mais, Mark E. Goldman, and Donald P. McDonnell, Molecular and Cellular Biology 14, 8356 (1994).
12. A. Albert, R. V. Randall, and R. A. Smith, Hormones and the Aging Process (Academic Press, Inc., New York, 1956).
13. R. T. Chlebowski, L. H. Kuller, R. L. Prentice, M. L. Stefanick, J. E. Manson, M. Gass, A. K. Aragaki, J. K. Ockene, D. S. Lane, G. E. Sarto, A. Rajkovic, R. Schenken, S. L. Hendrix, P. M. Ravdin, T. E. Rohan, S. Yasmeen, and G. Anderson, The New England Journal of Medicine 360, 573 (2009).
14. P. E. Goss, J. N. Ingle, S. Martino, N. Robert, H. B. Muss, M. J. Piccart, M. Castiglione, D. Tu, L. E. Shepherd, K. I. Pritchard, R. B. Livingston, N. E. Davidson, L. Norton, E. A. Perez, J. S. Abrams, D. A. Cameron, M. J. Palmer, and J. L. Pater, Journal of the National Cancer Institute 97, 1267 (2005).
15. J. Cuzick, I. Sestak, M. Baum, A. Buzdar, A. Howell, M. Dowsett, and J. F. Forbes, Lancet Oncol. 11, 1135 (2010).
16. C. Kim, G. Tang, K. L. Pogue-Geile, J. P. Costantino, F. L. Baehner, J. Baker, M. T. Cronin, D. Watson, S. Shak, O. L. Bohn, D. Fumagalli, Y. Taniyama, A. Lee, M. L. Reilly, V. G. Vogel, W. McCaskill-Stevens, L. G. Ford, C. E. Geyer Jr., D. L. Wickerham, N. Wolmark, and S. Paik, Journal of Clinical Oncology 29, 4160 (2011).
17. C. Schairer, J. Lubin, R. Troisi, S. Sturgeon, L. Brinton, and R. Hoover, The Journal of the American Medical Association 283, 485 (2000).
18. Writing Group for the Women's Health Initiative Investigator, The Journal of the American Medical Association 288, 321 (2002) and references within.
19. B. Katzenellenbogen, I. Choi, R. Delage-Mourroux, T. R. Ediger, P. G. V. Martini, M. Montano, J. Sun, K. Weis, and J. A. Katzenellenbogen, Journal of Steroid Biochemistry and Molecular Biology 74, 279 (2000).
20. P. Webb, P. Nguyen, and P. J. Kushner, J. Biol. Chem. 278, 6912 (2003).
21. M. Dutertre and C. L. Smith, The Journal of Pharmacology and Experimental Therapeutics 295, 431 (2000).
22. A. Goldhirsch, J. H. Glick, R. D. Gelber, and H.-J. Senn, Journal of the National Cancer Institute 90, 1601 (1998).
23. L. A. Emens and N. E. Davidson, Clinical Cancer Research 9, 280s (2003).
24. I. Wiklund, J. Karlberg, and L. A. Mattsson, American Journal of Obstetrics and Gynecology 168, 824 (1993).
25. J. N. Ingle, Breast Cancer Research 4, 133 (2002).
26. T. S. Wiley and B. Formby, Molecular Cell Biology 202, 53 (1999).
27. S. Formenti, J. Felix, D. Salonga, K. Danenberg, M. C. Pike, and P. Danenberg, Clinical Cancer Research 6, 4653 (2000).
28. J. Boney-Montoya, Y. S. Ziegler, C. D. Curtis, Jonathan A. Montoya, and A. M. Nardulli, Molecular Endocrinology 21, 439 (2010).
29. M. Guray and A. A. Sahin, The Oncologist 11, 435 (2006).
30. R. J. Santen and G. R. Petroni, The Journal of Clinical Endocrinology and Metabolism 84, 1875 (1999).
31. A. Fazzari, M. G. Catalano, A. Comba, M. Becchis, M. Raineri, R. Frairia, and N. Fortunati, Molecular and Cellular Endocrinology 172, 31 (2001).
32. V. C. Jordan and L. G. Ford, Cancer Prevention Research 10, 1158 (2011).
33. R. Ramakrishnan, S. A. Khan, and S. Badve, Modern Pathology 12, 1348 (2002).
34. O. M. Conneely, B. Mulac-Jericevic, J. P. Lydon, and F. J. De Mayo, Molecular and Cellular Endocrinology 179, (2001).
35. M.-E. Meyer, C. Quirin-Stricker, T. Lerouge, M.-T. Bocquel, and H. Gronemeyer, The Journal of Biological Chemistry 267, 10882 (1992).
36. E. B. Claus, N. J. Risch, and W. D. Thompson, American Journal of Epidemiology 131, 961 (1990).
37. J. Gauduchon, F. Guilleux, S. Maillard, V. Marsaud, M. Renoir, and B. Sola, Annals of New York Academy of Sciences 1010, 321 (2003).
38. E. Falkenstein, H.-C. Tillmann, M. Christ, M. Feuring, and M. Wehling, Pharmacological Reviews 52, 513 (2000).
39. S. L. Lightman, C. C. Wiles, H. C. Atkinson, D. E. Henley, G. M. Russell, J. A. Leendertz, M. A. McKenna, F. Spiga, S. A. Wood, and B. L. Conway-Campbell, European Journal of Pharmacology 583, 255 (2008).
40. E. Norjavaara, C. Ankarberg, and K. Albertsson-Wikland, Journal of Clinical Endocrinology and Metabolism 81, 4095 (1996).
41. X. Gao, B. W. Loggie, and Z. Nawaz, Molecular Cancer 1, 1186 (2002).
42. J. Taguchi, Unpublished work and private communications.
43. J. Williams, Unpublished work.

Data & Media loading...


Article metrics loading...



We present a theory that questions the standard of care for pre- and post-menopausal women with breast cancer. Through the use of modulated hormones to mimic the natural multiphasic fluctuations of estrogen and progesterone cycles of healthy young women, it can be expected that patients will not only exhibit increased quality of life such as better sleep, well-being, and libido, but also memory improvement and less joint pain. Additionally, this regimen may engage genetic pathways that protect women in youth from breast cancers. We present a mathematical basis for the coupling of the hormone cycles through the use of Gaussian curves that provides the foundation of a new format of hormone replacement in women.


Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: The theory of modulated hormone therapy for the treatment of breast cancer in pre- and post-menopausal women