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Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
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/content/aip/journal/adva/2/1/10.1063/1.3699063
2012-03-22
2014-10-23

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of protonirradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

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Scitation: Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
http://aip.metastore.ingenta.com/content/aip/journal/adva/2/1/10.1063/1.3699063
10.1063/1.3699063
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