NOTICE: Scitation Maintenance Sunday, March 1, 2015.

Scitation users may experience brief connectivity issues on Sunday, March 1, 2015 between 12:00 AM and 7:00 AM EST due to planned network maintenance.

Thank you for your patience during this process.

banner image
No data available.
Please log in to see this content.
You have no subscription access to this content.
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.
1. M. Durante and J. S. Loeffler, Nat. Rev. Clin. Oncol. 7, 37 (2010).
3. S. V. Bulanov, T. Z. Esirkepov, V. S. Khoroshkov, A. V. Kunetsov, and F. Pegoraro, Phys. Lett. A 299, 240 (2002).
4. V. Malka, S. Friztler, E. Lefevbre, E. d’Humieres, R. Ferrand, G. Grillon, C. Albaret, S. Meyroneinc, J. P. Chambaret, A. Antonetti, and D. Hulin, Med. Phys, 31, 1587 (2004).
5. E. Fourkal, J. S. Li, W. Xiong, A. Nahurn, and C. M. Ma, Phys. Med. Biol. 48, 3977 (2003).
6. S. D. Kraft, C. Richter1, K. Zeil1, M. Baumann, E. Beyreuther, S. Bock, M. Bussmann, T. E. Cowan, Y. Dammene, W. Enghardt, U. Helbig, L. Karsch, T. Kluge, L. Laschinsky, E. Lessmann, J. Metzkes, D. Naumburger, R. Sauerbrey, M. Schurer, M. Sobiella, J. Woithe, U. Schramm, and J. Pawelke, New Journal of Physics 12, 085003 (2010).
7. A. Yogo, K. Sato, M. Nishikino, M. Mori, T. Teshima, H. Numasaki, M. Murakami, Y. Demizu, S. Akagi, S. Nagayama, K. Ogura, A. Sagisaka, S. Orimo, M. Nishiuchi, A. S. Pirozhkov, M. Ikegami, M. Tampo, H. Sakaki, M. Suzuki, I. Daito, Y. Oishi, H. Sugiyama, H. Kiriyama, H. Okada, S. Kanazawa, S. Kondo, T. Shimomura, Y. Nakai, M. Tanoue, H. Sasao, D. Wakai, P. R. Bolton, and H. Daido, Appl. Phys. Lett. 94, 181502 (2009).
8. A. Yogo, T. Maeda, T. Hori, H. Sakaki, K. Ogura, M. Nishiuchi, A. Sagisaka, H. Kiriyama, H. Okada, S. Kanazawa, T. Shimomura, Y. Nakai, M. Tanoue, F. Sasao, P. R. Bolton, M. Murakami, T. Nomura, S. Kawanishi, and K. Kondo, Appl. Phys. Lett. 98. 053701 (2011).
9. C. Richter, L. Karsch, Y. Dammene, S. D. Kraft, J. Metzkes, U. Schramm, M. Schurer, M. Sobiella, A. Weber, K. Zeil, and J. Pawelke, Phys. Med. Biol. 56, 1529 (2011).
10. E. Fourkal, I. Veltchev, C-M Ma, and J. Fan, Phys. Med. Biol 56, 3123 (2011).
11. T. Dzelzainis, G. Nersisyan, D. Riley, B. Ramakrishna, L. Romagnani, M. Borghesi, D. Doria, B. Dromey, M. Makita, S. White, S. Kar, D. Marlow, G. Sarri, M. Zepf, and C. L. S. Lewis, Laser Part. Beams 28, 451 (2010).
12. S. C. Wilks, A. B. Langdon, T. E. Cowan, M. Roth, M. Singh, S. Hatchett, M. H. Key, D. Pennington, A. MacKinnon, and R. A. Snavely, Phys. Plasmas 8, 542 (2001).
13. M. Borghesi, J. Fuchs, S. V. Bulanov, A. J. Mackinnon, P. Patel, and M. Roth, Fusion Sci. Tech. 49, 412 (2006).
15. D. Kirby, S. Green, F. Fiorini, D. Parker, L. Romagnani, D. Doria, S. Kar, C. L. Lewis, M. Borghesi, and H. Palmans, Laser Part. Beams 29, 231 (2011).
16. T. G. Battistoni, F. Cerutti, A. Fassò, A. Ferrari, S. Muraro, J. Ranft, S. Roesler, and P. R. Sala, AIP Conf. Proc 896, 31 (2007).
17. F. Fiorini, D. Kirby, M. Borghesi, D. Doria, J. C. G. Jeynes, K. F. Kakolee, S. Kar, S. Kaur, K. J. Kirkby, M. J. Merchant, and S. Green, Phys. Med. Biol. 56, 6969 (2011).
18. G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, K. D. Held, and B. D. Michael, Radiat. Res. 160, 505 (2003).
19. B. G. Wouters, A. M. Sy, and L. D. Skarsgard, Radiat. Res. 146, 159170 (1996).
20. M. Folkard, K. M. Prise, B. Vojvonic, H. C. Newman, M. J Roper, and B. D. Michael, Int. J. Radiat. Biol 69, 729738 (1996).
21. J. F. Ziegler, M. D. Ziegler, and J. P. Biersack, Nucl Instr. Methods B Phys Res. 268, 18181823 (2010).
22. M. Belli, F. Cera, R. Cherubini, F. Ianzini, G. Moschini, O. Sapora, G. Simone, M. A. Tabocchini, and P. Tiveron, Int. J. Radiat. Biol 63, 331337 (1993).
23. S. Auer, V. Hable, C. Greubel, G. A. Drexler, T. E. Schmid, C. Belka, G. Dollinger, and A. A. Friedl, Radiation Oncology 6, 139 (2011).

Data & Media loading...


Article metrics loading...



The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of protonirradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.


Full text loading...

This is a required field
Please enter a valid email address
752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s