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Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays
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    Affiliations:
    1 Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    2 Clinical Investigations Facility, David Grant USAF Medical Center, Travis Air Force Base, CA 94535-1809, USA
    3 Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 2V4, Canada
    4 Department of Physics, University of Tennessee, Knoxville, TN 37996, USA
    5 Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996-2200, USA
    a) Author to whom correspondence should be addressed; electronic mail: passianan@ornl.gov
    AIP Advances 4, 037118 (2014); http://dx.doi.org/10.1063/1.4869636
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/content/aip/journal/adva/4/3/10.1063/1.4869636
2014-03-24
2014-07-26

Abstract

Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.

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752b84549af89a08dbdd7fdb8b9568b5 journal.articlezxybnytfddd
Scitation: Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays
http://aip.metastore.ingenta.com/content/aip/journal/adva/4/3/10.1063/1.4869636
10.1063/1.4869636
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