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Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays
6. A. Subramanian, P. I. Oden, S. J. Kennel, K. B. Jacobson, R. J. Warmack, T. Thundat, and M. J. Doktycz, Appl. Phys. Lett. 81, 385 (2002).
13. C. T. Witkop, M. R. Duffy, E. A. Macias, T. F. Gibbons, J. D. Escobar, K. N. Burwell, and K. K. Knight, American Journal of Preventive Medicine, 38(2), 121–126, (2010).
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Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.
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