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/content/aip/journal/adva/6/4/10.1063/1.4947301
1.
1.Y. Zhang, H. F. Chan, and K. W. Leong, “Advanced materials and processing for drug delivery: The past and the future,” Advanced Drug Delivery Reviews. 65, 104120 (2013).
http://dx.doi.org/10.1016/j.addr.2012.10.003
2.
2.J. W. Kan, Z. G. Yang, T. J. Peng, G. M. Cheng, and B. D. Wu, “Design and test of a high-performance piezoelectric micropump for drug delivery,” Sens. Actuators, A. 121, 156161 (2005).
http://dx.doi.org/10.1016/j.sna.2004.12.002
3.
3.A. T. Evans, J. M. Park, S. Chiravuri, and Y. B. Gianchandani, “A low power, microvalve regulated architecture for drug delivery systems,” Biomed Microdevices. 12, 159168 (2010).
http://dx.doi.org/10.1007/s10544-009-9372-y
4.
4.A.C. Eijka, A.J. Plasb, C.J.N.M. Palenb, J. Dankelmana, and B.J. Smitd, “In vitro measurement of flow rate variability in neonatal IV therapy with and without the use of check valves,” Journal of Neonatal-Perinatal Medicine. 7, 5564 (2014).
5.
5.T. Li, A. T. Evans, S. Chiravuri, R. Y. Gianchandani, and Y. B. Gianchandani, “Compact, power-efficient architectures using microvalves and microsensors, for intrathecal, insulin, and other drug delivery systems,” Advanced Drug Delivery Reviews. 64, 16391649 (2012).
http://dx.doi.org/10.1016/j.addr.2012.05.002
6.
6.L. Cao, S. Mantell, and D. Polla, “Design and simulation of an implantable medical drug delivery system using microelectrome-chanical systems technology,” Sens. Actuators, A. 94, 117125 (2001).
http://dx.doi.org/10.1016/S0924-4247(01)00680-X
7.
7.S. M. Yuan, C. Zhu, X. H. Chu, Y. Q. Zhao, M. Amin, and Y. L. Fan, “A novel linear piezoelectric actuator with two working principles of standing and traveling wave vibration mode,” AIP Advances. 5, 107213 (2015).
http://dx.doi.org/10.1063/1.4933435
8.
8.H. Kim, C. H In, G. Yoon, and J. Kim, “A slim type microvalve driven by PZT films,” Sens. Actuators, A. 121, 162171 (2005).
http://dx.doi.org/10.1016/j.sna.2004.12.005
9.
9.A. Masiello, S. D. Bello, M. Fincato, and F. Rossetto, “Performance of modified pulse-operated piezoelectric valves for the gas inlet system of RFX,” Fusion Engineering and Design. 82, 22822287 (2007).
http://dx.doi.org/10.1016/j.fusengdes.2007.06.020
10.
10.M. Sobocinski, J. Juuti, H. Jantunen, and L. Golonka, “Piezoelectric unimorph valve assembled on an LTCC substrate,” Sens. Actuators, A. 149, 315319 (2009).
http://dx.doi.org/10.1016/j.sna.2008.11.025
11.
11.H.B. Zhao, K. Stanley, Q.M. J. Wu, and E. Czyzewska, “Structure and characterization of a planar normally closed bulk-micromachined piezoelectric valve for fuel cell applications,” Sens. Actuators, A. 120, 134141 (2005).
http://dx.doi.org/10.1016/j.sna.2004.11.037
12.
12.T. Ninomiya, Y. Okayama, Y. Matsumoto, X. Arouette, K. Osawa, and N. Miki, “MEMS-based hydraulic displacement amplification mechanism with completely encapsulated liquid,” Sens. Actuators, A. 166, 277282 (2011).
http://dx.doi.org/10.1016/j.sna.2009.07.002
13.
13.X. Arouette, Y. Matsumoto, T. Ninomiya, Y. Okayama, and N. Miki, “Dynamic Characteristics of a Hydraulic Amplification Mechanism for Large Displacement Actuators Systems,” Sensors. 10, 29462956 (2010).
http://dx.doi.org/10.3390/s100402946
14.
14.D.C. Roberts, H.Q Li, J.L Steyn, O Yaglioglu, and S. M Spearing, “A Piezoelectric Microvalve for Compact High-Frequency, High-Differential Pressure Hydraulic Micropumping Systems,” Journal of Microelectromechanical Systems. 12(1), 8192 (2003).
http://dx.doi.org/10.1109/JMEMS.2002.807471
15.
15.H.Q Li, D.C Roberts, J.L Steyn, K.T Turner, O Yaglioglu, N.W Hagood, S.M Spearing, and Schmidt, “Fabrication of a high frequency piezoelectric microvalve,” Sens. Actuators, A. 111, 5156 (2004).
http://dx.doi.org/10.1016/j.sna.2003.10.013
16.
16.T. Goettschea, J. Kohnlea, M. Willmanna, H. Ernsta, S. Spietha, R. Tischlera, S. Messnera, R. Zengerleb, and H. Sandmaiera, “Novel approaches to particle tolerant valves for use in drug delivery systems,” Sens. Actuators, A. 118, 7077 (2005).
http://dx.doi.org/10.1016/j.sna.2004.08.007
17.
17.H. Ernst, M. Willmann, T Goettsche, J. Kohnle, H. Sandmaier, and R. Zengerle, “Energy Optimized Valves with Low Leakage Rates,” in Proceedings of the Fifth Micro-Fluidics Symposium IMECE (Orlando, Florida, USA, 2000).
18.
18.X. S. Wu, S. H. Kim, C. H. Ji, and M. G. Allen, “A solid hydraulically amplified piezoelectric microvalve,” Journal of Micromechanics and Microengineering. 21, 095003095014 (2011).
http://dx.doi.org/10.1088/0960-1317/21/9/095003
19.
19.H. Xu, C. Wang, C.L. Wang, J. Zoval, and M. Madou, “Polymer actuator valves toward controlled drug delivery application,” Biosensors and Bioelectronics. 21, 20942099 (2006).
http://dx.doi.org/10.1016/j.bios.2005.10.020
20.
20.Y Liu, PhD Thesis, Jilin University, 2012.
http://aip.metastore.ingenta.com/content/aip/journal/adva/6/4/10.1063/1.4947301
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/content/aip/journal/adva/6/4/10.1063/1.4947301
2016-04-18
2016-10-01

Abstract

In the field of controlleddrug delivery system, there are still many problems on those reported micro-valves, such as the small opening height, unsatisfactory particle tolerance and high cost. To solve the above problems, a novel normally-closed piezoelectric micro-valve is presented in this paper. The micro-valve was driven by circular unimorph piezoelectric vibrator and natural rubber membrane with high elasticity was used as the valve stopper. The small axial displacement of piezoelectric vibrator can be converted into a large stroke of valve stopper based on hydraulic amplification mechanism. The experiment indicates that maximum hydraulic amplification ratio is up to 14, and the cut-off pressure of the micro-valve is 39kPa in the case of no working voltage. The presented micro valve has a large flow control range (ranging from 0 to 8.75mL/min).

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